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VALENCE-REPLAY SIGNED

Disentangling amygdala contributions to replay-mediated, hippocampal-dependent memory consolidation

Total Cost €

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EC-Contrib. €

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Partnership

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 Outcomes and results

 VALENCE-REPLAY project word cloud

Explore the words cloud of the VALENCE-REPLAY project. It provides you a very rough idea of what is the project "VALENCE-REPLAY" about.

electrophysiology    forming    recording    permit    goals    workplace    sustainable    schedules    shaped    emotions    experiments    techniques    function    emotion    therapeutic    time    are    mechanistic    building    multisite    hippocampus    shape    amygdala    dr    researcher    network    regulation    interact    lengths    shed    wellbeing    rodents    neuronal    prior    scientific    translate    level    memory    functions    behaving    neuroscience    gap    losses    ventral    acquire    busy    healthcare    symptoms    probe    block    functional    daytime    brain    probes    preferentially    basic    single    interactions    health    group    mental    perentos    tool    experience    fellowship    takes    afford    valence    training    mediate    leaders    light    emotional    independent    opportunity    smart    societies    committed    professional    neuron    rest    replay    sleep    outlined    optogenetic    consolidation    questions    lack    parylene    institutes    modern    tracking    accomplished    productivity    place    personal    fabrication   

Project "VALENCE-REPLAY" data sheet

The following table provides information about the project.

Coordinator		 LUDWIG-MAXIMILIANS-UNIVERSITAET MUENCHEN 

Organization address
address: GESCHWISTER SCHOLL PLATZ 1
city: MUENCHEN
postcode: 80539
website: www.uni-muenchen.de

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.
 Coordinator Country Germany [DE]
 Project website http://www.nperentos.com
 Total cost 171˙460 €
 EC max contribution 171˙460 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2016
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2017
 Duration (year-month-day) from 2017-10-15   to  2019-10-14

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    LUDWIG-MAXIMILIANS-UNIVERSITAET MUENCHEN DE (MUENCHEN) coordinator 171˙460.00

Map

 Project objective

In today’s societies, adequate rest takes second place to busy professional and personal schedules. It is known that lack of rest and sleep affects mental health, emotional regulation and daytime function. Such symptoms translate to increased healthcare costs and losses in workplace productivity. How emotional regulation processes interact with sleep and associated memory consolidation functions is not well understood. In addition to increasing basic understanding of brain function, addressing this knowledge gap can help shape therapeutic approaches for mental wellbeing and contribute to EU’s H2020 goals of smart, sustainable and growth.

VALENCE-REPLAY will provide a building block towards addressing this knowledge gap through experiments in behaving rodents. The questions to be addressed in this fellowship are: Are memory consolidation processes during sleep preferentially shaped according to the valence of prior experience? If this is so, how is this accomplished at a mechanistic level?

The work will use modern electrophysiology and optogenetic techniques to probe functional interactions of brain areas that mediate emotion (amygdala) and memory (hippocampus) and the role of these interactions in memory replay and consolidation during sleep. The project will also lead to fabrication of a new tool, parylene-based multisite neuronal recording probes that will permit tracking single neuron activity from the ventral hippocampus for adequate lengths of time to address the outlined research goals.

The fellowship will shed light on how emotions shape memory processes during sleep, but will also afford a committed and experienced researcher the opportunity to acquire advanced training at leading European neuroscience institutes while forming a strong scientific network with leaders in the field. Through VALENCE-REPLAY, Dr Perentos will develop into an independent researcher, able to lead his own research group and achieve high impact research in systems neuroscience.

 Publications

year authors and title journal last update
List of publications.
2019 Fabio Boi, Nikolas Perentos, Aziliz Lecomte, Gerrit Schwesig, Stefano Zordan, Anton Sirota, Luca Berdondini, Gian Nicola Angotzi
Multi-shanks SiNAPS Active Pixel Sensor CMOS probe: 1024 simultaneously recording channels for high-density intracortical brain mapping
published pages: , ISSN: , DOI: 		bioRxiv 2020-04-08

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The information about "VALENCE-REPLAY" are provided by the European Opendata Portal: CORDIS opendata.

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