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VALENCE-REPLAY SIGNED

Disentangling amygdala contributions to replay-mediated, hippocampal-dependent memory consolidation

Total Cost €

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EC-Contrib. €

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Partnership

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 Outcomes and results

 VALENCE-REPLAY project word cloud

Explore the words cloud of the VALENCE-REPLAY project. It provides you a very rough idea of what is the project "VALENCE-REPLAY" about.

healthcare    wellbeing    personal    multisite    consolidation    tool    committed    symptoms    functions    block    brain    gap    neuroscience    training    shaped    lack    busy    function    sustainable    workplace    dr    memory    probes    societies    mediate    scientific    time    electrophysiology    neuron    modern    permit    acquire    tracking    perentos    lengths    emotions    rest    group    accomplished    prior    questions    losses    ventral    behaving    outlined    schedules    preferentially    experience    opportunity    replay    researcher    light    are    shape    leaders    rodents    afford    independent    health    hippocampus    takes    productivity    emotional    fellowship    basic    level    translate    network    place    mechanistic    interact    regulation    daytime    building    functional    therapeutic    optogenetic    probe    fabrication    valence    forming    techniques    smart    shed    recording    institutes    goals    mental    neuronal    sleep    professional    experiments    interactions    amygdala    single    parylene    emotion   

Project "VALENCE-REPLAY" data sheet

The following table provides information about the project.

Coordinator		 LUDWIG-MAXIMILIANS-UNIVERSITAET MUENCHEN 

Organization address
address: GESCHWISTER SCHOLL PLATZ 1
city: MUENCHEN
postcode: 80539
website: www.uni-muenchen.de

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.
 Coordinator Country Germany [DE]
 Project website http://www.nperentos.com
 Total cost 171˙460 €
 EC max contribution 171˙460 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2016
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2017
 Duration (year-month-day) from 2017-10-15   to  2019-10-14

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    LUDWIG-MAXIMILIANS-UNIVERSITAET MUENCHEN DE (MUENCHEN) coordinator 171˙460.00

Map

 Project objective

In today’s societies, adequate rest takes second place to busy professional and personal schedules. It is known that lack of rest and sleep affects mental health, emotional regulation and daytime function. Such symptoms translate to increased healthcare costs and losses in workplace productivity. How emotional regulation processes interact with sleep and associated memory consolidation functions is not well understood. In addition to increasing basic understanding of brain function, addressing this knowledge gap can help shape therapeutic approaches for mental wellbeing and contribute to EU’s H2020 goals of smart, sustainable and growth.

VALENCE-REPLAY will provide a building block towards addressing this knowledge gap through experiments in behaving rodents. The questions to be addressed in this fellowship are: Are memory consolidation processes during sleep preferentially shaped according to the valence of prior experience? If this is so, how is this accomplished at a mechanistic level?

The work will use modern electrophysiology and optogenetic techniques to probe functional interactions of brain areas that mediate emotion (amygdala) and memory (hippocampus) and the role of these interactions in memory replay and consolidation during sleep. The project will also lead to fabrication of a new tool, parylene-based multisite neuronal recording probes that will permit tracking single neuron activity from the ventral hippocampus for adequate lengths of time to address the outlined research goals.

The fellowship will shed light on how emotions shape memory processes during sleep, but will also afford a committed and experienced researcher the opportunity to acquire advanced training at leading European neuroscience institutes while forming a strong scientific network with leaders in the field. Through VALENCE-REPLAY, Dr Perentos will develop into an independent researcher, able to lead his own research group and achieve high impact research in systems neuroscience.

 Publications

year authors and title journal last update
List of publications.
2019 Fabio Boi, Nikolas Perentos, Aziliz Lecomte, Gerrit Schwesig, Stefano Zordan, Anton Sirota, Luca Berdondini, Gian Nicola Angotzi
Multi-shanks SiNAPS Active Pixel Sensor CMOS probe: 1024 simultaneously recording channels for high-density intracortical brain mapping
published pages: , ISSN: , DOI: 		bioRxiv 2020-04-08

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The information about "VALENCE-REPLAY" are provided by the European Opendata Portal: CORDIS opendata.

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