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FiTTeR

Developing a Fibrosis Targeting and Tissue Reparative (FiTTeR) Therapy for the Infarcted Myocardium via an Injectable Functionalized Extracellular Matrix Hydrogel

Total Cost €

EC-Contrib. €

Partnership

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Outcomes and
results

FiTTeR project word cloud

Explore the words cloud of the FiTTeR project. It provides you a very rough idea of what is the project "FiTTeR" about.

broad ideal mitigate gained infarction mmps therapies modulation world injectable immunomodulatory matrix pathologic hydrogels hydrogel recombinant efficacy imperial mi cryptic recombinantly myocardial college awards icl life cell exist advantageous prevent cells prof carrier platform regulate fragment science tethered localized realized molly shown local isolated onset suited technologies protein perform host as biomaterial extracellular london supervision sustained group combination repair outcomes combined odowska class sophisticated ecm background fellow degradation sk consist characterizing immune interfacing ideally release tissue simultaneously 2014 stevens regulatory vivo translating marie biomaterials interdisciplinary fibrosis abrogate phenotype expertise curie metalloproteinases

Project "FiTTeR" data sheet

The following table provides information about the project.

Coordinator	IMPERIAL COLLEGE OF SCIENCE TECHNOLOGY AND MEDICINE Organization address address: SOUTH KENSINGTON CAMPUS EXHIBITION ROAD city: LONDON postcode: SW7 2AZ website: http://www.imperial.ac.uk/ contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.
Coordinator Country	United Kingdom [UK]
Project website	http://www.stevensgroup.org/index.php/people/cat/researchers
Total cost	195˙454 €
EC max contribution	195˙454 € (100%)
Programme	1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
Code Call	H2020-MSCA-IF-2016
Funding Scheme	MSCA-IF-EF-ST
Starting year	2017
Duration (year-month-day)	from 2017-08-21 to 2019-08-20

Partnership

Take a look of project's partnership.

#	participants	country	role	EC contrib. [€]
1	IMPERIAL COLLEGE OF SCIENCE TECHNOLOGY AND MEDICINE IMPERIAL COLLEGE OF SCIENCE TECHNOLOGY AND MEDICINE Organization address address: SOUTH KENSINGTON CAMPUS EXHIBITION ROAD city: LONDON postcode: SW7 2AZ website: http://www.imperial.ac.uk/ contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	UK (LONDON)	coordinator	195˙454.00

Map

Project objective

As a Marie SkÅ‚odowska-Curie Fellow, I will develop, characterize, and determine the efficacy of a biomaterial platform to target pathologic fibrosis and promote tissue repair following myocardial infarction (MI). I have an ideal background and will perform well in this project based on my expertise in extracellular matrix (ECM) derived biomaterials, characterizing the immune response to biomaterials, and evaluating in vivo outcomes. The proposed system will consist of a protein fragment tethered to an injectable hydrogel. The hydrogel carrier will be composed of ECM, which has been shown to facilitate tissue repair processes by local modulation of immune cell phenotype . The cryptic protein fragment, recently isolated and recombinantly produced by the Stevens Group , has gained attention for its ability to regulate the onset of fibrosis by interfacing with cells to abrogate the release of matrix metalloproteinases (MMPs). No therapies currently exist to prevent or mitigate fibrosis. Developing a sophisticated delivery system for a cryptic protein fragment will enable the broad potential of targeting pathologic fibrosis to be realized. This system will be advantageous in simultaneously providing localized delivery, combined immunomodulatory and regulatory properties of the ECM and recombinant protein fragment, and sustained release of the protein fragment during degradation of the ECM hydrogel. The combination of my expertise (in ECM hydrogels, characterizing the host response to biomaterials, and translating technologies) and Prof Molly Stevens’s supervision and world-class interdisciplinary biomaterials-focused group, the 2014 Research Group of the Year (European Life Science Awards), at Imperial College London (ICL), together make this project ideally suited for success.

Publications

List of publications.
year	authors and title	journal	last update
2018	Gregor Fuhrmann, Rona Chandrawati, Paresh A. Parmar, Timothy J. Keane, Stephanie A. Maynard, Sergio Bertazzo, Molly M. Stevens Engineering Extracellular Vesicles with the Tools of Enzyme Prodrug Therapy published pages: 1706616, ISSN: 0935-9648, DOI: 10.1002/adma.201706616	Advanced Materials 30/15	2020-03-06

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