Opendata, web and dolomites

SUBDECODE SIGNED

Dendritic encoding of movement in space

Total Cost €

0

EC-Contrib. €

0

Partnership

0

Views

0

 SUBDECODE project word cloud

Explore the words cloud of the SUBDECODE project. It provides you a very rough idea of what is the project "SUBDECODE" about.

dissect    models    prediction    sense    cellular    greatest    dendritic    incorporated    predicting    neocortical    dorsal    pyramidal    decode    transformation    dense    unravelling    membrane    function    synapses    tuning    photon    chemogenetic    quest    generation    map    model    output    neuroengineering    synaptic    patch    interface    converting    patterns    brain    neural    mice    memory    transients    decoding    observations    form    dissection    basis    neuroscience    understanding    contains    fundamental    individual    neuronal    space    diversity    networks    guided    relationship    central    navigational    cell    navigating    representation    impossible    behavioural    spatial    imaging    navigation    tracing    free    network    recordings    conversion    precise    unresolved    attempt    functional    initiated    subicular    realistic    biophysical    silencing    engaged    tune    final    mono    spines    neurons    input    clamp    computation    faces    origins    inputs    perspectives    ca2    hippocampal    single    distributed    units    data    subiculum    resolution    outputs    knowing    transsynaptic   

Project "SUBDECODE" data sheet

The following table provides information about the project.

Coordinator
LEIBNIZ-INSTITUT FUER NEUROBIOLOGIE 

Organization address
address: BRENNECKESTRASSE 6
city: MAGDEBURG
postcode: 39118
website: www.ifn-magdeburg.de

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Germany [DE]
 Total cost 1˙806˙068 €
 EC max contribution 1˙806˙068 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2016-COG
 Funding Scheme ERC-COG
 Starting year 2017
 Duration (year-month-day) from 2017-05-01   to  2022-04-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    LEIBNIZ-INSTITUT FUER NEUROBIOLOGIE DE (MAGDEBURG) coordinator 482˙906.00
2    DEUTSCHES ZENTRUM FUR NEURODEGENERATIVE ERKRANKUNGEN EV DE (BONN) participant 1˙323˙161.00

Map

 Project objective

Understanding the neuronal basis of behaviour is a central quest for neuroscience. Neurons are the fundamental units of computation in the brain. Thus, any attempt at unravelling the relationship of neural networks activity and behaviour must be based on an understanding of the transformation of inputs to outputs in single neurons. One of the greatest challenges that our field faces is to make sense of inputs. Without knowing how different synaptic inputs are engaged during behaviour, it is impossible to decode the neuronal input to output conversion. We have developed an approach that allows both the dissection of inputs and the prediction of output during behaviour. We will apply this functional decoding approach to pyramidal neurons in the dorsal subiculum. These neurons form a hippocampal-neocortical interface and are important for memory-guided navigation. The output of subicular neurons contains a dense, distributed representation of space, but the functional input diversity is unresolved. Following the generation of a spatial tuning map during navigational tasks with two-photon Ca2 imaging at cellular-resolution, we will map the input origins of individual neurons by using targeted single-cell initiated mono-transsynaptic tracing. Then, we will dissect the function of the input from different origins by chemogenetic silencing of input synapses. As a central component of the project, we will map dendritic input patterns in navigating mice with two-photon imaging of Ca2 transients on dendritic spines. These patterns will be incorporated into a data-driven biophysical model capable of converting realistic synaptic inputs into output. We will tune the model parameters using whole-cell patch-clamp recordings during free behaviour. The final models will be capable of predicting the membrane potential of subicular neurons from precise behavioural observations, offering exciting new perspectives for network analysis and neuroengineering.

Are you the coordinator (or a participant) of this project? Plaese send me more information about the "SUBDECODE" project.

For instance: the website url (it has not provided by EU-opendata yet), the logo, a more detailed description of the project (in plain text as a rtf file or a word file), some pictures (as picture files, not embedded into any word file), twitter account, linkedin page, etc.

Send me an  email (fabio@fabiodisconzi.com) and I put them in your project's page as son as possible.

Thanks. And then put a link of this page into your project's website.

The information about "SUBDECODE" are provided by the European Opendata Portal: CORDIS opendata.

More projects from the same programme (H2020-EU.1.1.)

HyperBio (2019)

Vis-NIR Hyperspectral imaging for biomaterial quality control

Read More  

ENTRAPMENT (2019)

Septins: from bacterial entrapment to cellular immunity

Read More  

KineTic (2020)

New Reagents for Quantifying the Routing and Kinetics of T-cell Activation

Read More