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UVdynamicsProtection SIGNED

Aligning pigmentation and repair: a holistic approach for UV protection dynamics

Total Cost €

EC-Contrib. €

Partnership

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UVdynamicsProtection project word cloud

Explore the words cloud of the UVdynamicsProtection project. It provides you a very rough idea of what is the project "UVdynamicsProtection" about.

uv central hazards issue accompanied dna molecular intervals body skin reaching opportunity holistic avenues oscillatory tools protection theory regarding scales cellular missing underlying mitf breaking hours despite ground expression output physiological found total hypothesize elucidate first markers did perspectives breakthrough utilizing uncover regulation dosage protect behaviours serve mouse regulator dynamics schedule extensive experimental damped repair synchronize accounts temporal timing exposed simultaneously pigmentation cancer dictates interval takes correlate minutes ed analytical prevention itself goals 48hr subsystems 24hr days purpose exposure dynamic lasts mechanisms melanocyte transcriptional hence time human complementary exhibits

Project "UVdynamicsProtection" data sheet

The following table provides information about the project.

Coordinator	TEL AVIV UNIVERSITY Organization address address: RAMAT AVIV city: TEL AVIV postcode: 69978 website: http://www.tau.ac.il/ contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.
Coordinator Country	Israel [IL]
Total cost	1˙971˙875 €
EC max contribution	1˙971˙875 € (100%)
Programme	1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
Code Call	ERC-2016-COG
Funding Scheme	ERC-COG
Starting year	2017
Duration (year-month-day)	from 2017-04-01 to 2022-03-31

Partnership

Take a look of project's partnership.

#	participants	country	role	EC contrib. [€]
1	TEL AVIV UNIVERSITY TEL AVIV UNIVERSITY Organization address address: RAMAT AVIV city: TEL AVIV postcode: 69978 website: http://www.tau.ac.il/ contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	IL (TEL AVIV)	coordinator	1˙971˙875.00

Map

Project objective

The human body takes different measures in order to protect itself against the results of UV exposure and its accompanied hazards, such as skin cancer. Despite extensive studies regarding the molecular regulation of the two main UV protection mechanisms, namely, the DNA repair system and the pigmentation system, a comprehensive theory that simultaneously accounts for the two systems is still missing. Hence, the ground-breaking goal of this proposal is to elucidate, for the first time, the dynamic control used to schedule and synchronize the UV protection subsystems. Since these two systems serve the same physiological purpose, but on different time scales (DNA repair takes minutes, while pigmentation lasts hours to days), I propose to take the novel approach of focusing on their timing as an opportunity to uncover their regulation. As a first step, we exposed human and mouse skin to UV and found that UV exposure at 48hr intervals resulted in higher skin pigmentation than did exposure at 24hr intervals, even after controlling for total UV dosage. Furthermore, we found that the expression level of the melanocyte central regulator, MITF, exhibits damped oscillatory behaviour during this 48hr interval. I therefore hypothesize that the dynamic behaviour of the central regulator dictates the UV–response timing of the two protection systems. In the proposed research, I will take a holistic approach and address this issue from three complementary perspectives: (1) transcriptional dynamics, (2) temporal effects on cellular output, and (3) DNA repair after UV. This will be achieved by utilizing and developing new experimental and analytical tools that will allow us to correlate the temporal behaviours of a wide set of molecular markers. Reaching our goals will provide a breakthrough in our understanding of skin protection from UV and the underlying mechanisms that control it. These findings may offer exciting new avenues for future skin cancer prevention.

Publications

List of publications.
year	authors and title	journal	last update
2017	Danna Sheinboim, Itay Maza, Iris Dror, Shivang Parikh, Vladislav Krupalnik, Rachel E. Bell, Asaf Zviran, Yusuke Suita, Ofir Hakim, Yael Mandel-Gutfreund, Mehdi Khaled, Jacob H. Hanna, Carmit Levy OCT4 impedes cell fate redirection by the melanocyte lineage master regulator MITF in mouse ESCs published pages: , ISSN: 2041-1723, DOI: 10.1038/s41467-017-01122-1	Nature Communications 8/1	2019-04-18

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