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BaskAtax

Modulation of Basket cell microcircuits in cerebellar cortex paroxysmal ataxia disorders

Total Cost €

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EC-Contrib. €

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Partnership

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 BaskAtax project word cloud

Explore the words cloud of the BaskAtax project. It provides you a very rough idea of what is the project "BaskAtax" about.

regulation    migraine    models    cortex    terminals    msc    behavioural    mutations    episodic    model    mechanism    inherited    disorder    inhibitory    ataxias    therapeutic    recurring    vitro    conventional    share    paroxysmal    ataxia    function    mutation    group    possibly    cutting    dysfunction    experiments    unknown    similarities    human    neuropharmacology    incoordination    missense    prevalent    microscopy    action    hereditary    basket    cell    global    channel    vivo    train    subunit    cerebellar    microcircuits    edge    rare    firing    biochemistry    candidate    assay    drawing    extensive    dominantly    linked    whereby    attacks    kv1    me    prototypic    harbouring    structure    small    therapies    extend    animal    neurological    network    mouse    pinceau    synaptic    techniques    unforeseen    paroxysms    combination    epilepsy    purkinje    background    building    local    ea1    specialized    disorders    deficits    reveals    potassium    unclear    understand    molecule    altered    electrophysiology    map    photon   

Project "BaskAtax" data sheet

The following table provides information about the project.

Coordinator
UNIVERSITY COLLEGE LONDON 

Organization address
address: GOWER STREET
city: LONDON
postcode: WC1E 6BT
website: n.a.

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country United Kingdom [UK]
 Project website https://www.ucl.ac.uk/ion/research/synaptopathies/principal-investigators/dimitri-m-kullmann
 Total cost 195˙454 €
 EC max contribution 195˙454 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2016
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2017
 Duration (year-month-day) from 2017-10-01   to  2019-09-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNIVERSITY COLLEGE LONDON UK (LONDON) coordinator 195˙454.00

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 Project objective

The episodic ataxias are a group of hereditary conditions with recurring paroxysms of cerebellar dysfunction. They are rare; however they share important similarities to other more prevalent paroxysmal disorders such as migraine and epilepsy. The prototypic cerebellar cortex paroxysmal disorder is Episodic ataxia 1 (EA1), which is linked to dominantly inherited missense mutations in the Kv1.1 potassium channel subunit. Work from an animal model harbouring a human EA1 mutation reveals altered synaptic function at basket cell terminals in the cerebellar cortex. However how EA1 mutations affect basket cell regulation of Purkinje cell firing is unclear, possibly due to unforeseen changes in a specialized inhibitory structure called the pinceau. Furthermore the mechanism whereby local synaptic deficits extend to global cerebellar cortex network dysfunction during attacks of incoordination is unknown. This MSC research action aims to understand these processes using a combination of cutting edge in vitro and in vivo techniques. Using advanced electrophysiology techniques, I will assay basket cell pinceau function in mouse models of EA1, then using multi-photon and conventional microscopy I will map local basket cell microcircuits. Finally building on in vitro experiments I will assay candidate small molecule therapies in vivo, both with electrophysiology and with behavioural test of cerebellar coordination. The project allows me to train in state-of-the-art in vitro and in vivo methods while drawing on my extensive background in neuropharmacology, biochemistry electrophysiology. This research action will also advance our understanding of paroxysmal neurological disorders and identify new therapeutic targets.

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The information about "BASKATAX" are provided by the European Opendata Portal: CORDIS opendata.

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