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INNODIA SIGNED

Translational approaches to disease modifying therapy of type 1 diabetes: an innovative approach towards understanding and arresting type 1 diabetes – Sofia ref.: 115797

Total Cost €

EC-Contrib. €

Partnership

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Outcomes and
results

INNODIA project word cloud

Explore the words cloud of the INNODIA project. It provides you a very rough idea of what is the project "INNODIA" about.

infrastructure oriented accelerate family consented registries adults provides collected cure immunology translating collection biomarkers prevention urine trials designed subjects trial preclinical science public progress companies active at medicines standardized appropriately joins diagnosis expertise biosamples made translation disease t1d patients innodia biorepositories cell models recruit children blood members move serum pathophysiology vitro establishment phenotyped relatives longitudinal interventions oversee animal basic living prospective stools metabolic biomarker discovery recall create phenotyping clinical bioinformatics coordinated pharmaceutical breakthrough genetic samples closer populations diabetes historical regulators beta diverse network risk plasma biological experts individuals biology collaborative biobank clinicians deep

Project "INNODIA" data sheet

The following table provides information about the project.

Coordinator	KATHOLIEKE UNIVERSITEIT LEUVEN Organization address address: OUDE MARKT 13 city: LEUVEN postcode: 3000 website: www.kuleuven.be contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.
Coordinator Country	Belgium [BE]
Total cost	35˙558˙967 €
EC max contribution	17˙630˙000 € (50%)
Programme	1. H2020-EU.3.1.7. (Innovative Medicines Initiative 2 (IMI2))
Code Call	H2020-JTI-IMI2-2014-01-two-stage
Funding Scheme	IMI2-RIA
Starting year	2015
Duration (year-month-day)	from 2015-11-01 to 2022-10-31

Partnership

Take a look of project's partnership.

#	participants	country	role	EC contrib. [€]
1	KATHOLIEKE UNIVERSITEIT LEUVEN KATHOLIEKE UNIVERSITEIT LEUVEN Organization address address: OUDE MARKT 13 city: LEUVEN postcode: 3000 website: www.kuleuven.be contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	BE (LEUVEN)	coordinator	2˙319˙083.00
2	INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE Organization address address: RUE DE TOLBIAC 101 city: PARIS postcode: 75654 website: www.inserm.fr contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	FR (PARIS)	participant	2˙036˙350.00
3	THE CHANCELLOR MASTERS AND SCHOLARSOF THE UNIVERSITY OF CAMBRIDGE THE CHANCELLOR MASTERS AND SCHOLARSOF THE UNIVERSITY OF CAMBRIDGE Organization address address: TRINITY LANE THE OLD SCHOOLS city: CAMBRIDGE postcode: CB2 1TN website: www.cam.ac.uk contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	UK (CAMBRIDGE)	participant	1˙864˙513.00
4	KOBENHAVNS UNIVERSITET KOBENHAVNS UNIVERSITET Organization address address: NORREGADE 10 city: KOBENHAVN postcode: 1165 website: www.ku.dk contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	DK (KOBENHAVN)	participant	1˙132˙000.00
5	TECHNISCHE UNIVERSITAET DRESDEN TECHNISCHE UNIVERSITAET DRESDEN Organization address address: HELMHOLTZSTRASSE 10 city: DRESDEN postcode: 1069 website: http://www.tu-dresden.de/ contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	DE (DRESDEN)	participant	1˙131˙000.00
6	REGION HOVEDSTADEN REGION HOVEDSTADEN Organization address address: KONGENS VAENGE 2 city: HILLEROD postcode: 3400 website: www.regionh.dk contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	DK (HILLEROD)	participant	1˙130˙450.00
7	HELSINGIN YLIOPISTO HELSINGIN YLIOPISTO Organization address address: YLIOPISTONKATU 3 city: HELSINGIN YLIOPISTO postcode: 14 website: www.helsinki.fi contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	FI (HELSINGIN YLIOPISTO)	participant	703˙642.00
8	HANNOVERSCHE KINDERHEILANSTALT HANNOVERSCHE KINDERHEILANSTALT Organization address address: JANUSZ KORCZAK ALLEE 12 city: HANNOVER postcode: 30173 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	DE (HANNOVER)	participant	646˙730.00
9	UNIVERSITE LIBRE DE BRUXELLES UNIVERSITE LIBRE DE BRUXELLES Organization address address: AVENUE FRANKLIN ROOSEVELT 50 city: BRUXELLES postcode: 1050 website: www.ulb.ac.be contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	BE (BRUXELLES)	participant	604˙656.00
10	ACADEMISCH ZIEKENHUIS LEIDEN ACADEMISCH ZIEKENHUIS LEIDEN Organization address address: ALBINUSDREEF 2 city: LEIDEN postcode: 2333 ZA website: www.lumc.nl contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	NL (LEIDEN)	participant	518˙926.00
11	UNIVERSITA DEGLI STUDI DI SIENA UNIVERSITA DEGLI STUDI DI SIENA Organization address address: VIA BANCHI DI SOTTO 55 city: SIENA postcode: 53100 website: www.unisi.it contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	IT (SIENA)	participant	474˙189.00
12	TURUN YLIOPISTO TURUN YLIOPISTO Organization address address: YLIOPISTONMAKI city: Turku postcode: 20014 website: www.utu.fi contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	FI (Turku)	participant	468˙000.00
13	UNIVERSITA DI PISA UNIVERSITA DI PISA Organization address address: LUNGARNO PACINOTTI 43/44 city: PISA postcode: 56126 website: www.unipi.it contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	IT (PISA)	participant	423˙000.00
14	OULUN YLIOPISTO OULUN YLIOPISTO Organization address address: PENTTI KAITERAN KATU 1 city: OULU postcode: 90014 website: www.oulu.fi contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	FI (OULU)	participant	414˙750.00
15	STICHTING KATHOLIEKE UNIVERSITEIT STICHTING KATHOLIEKE UNIVERSITEIT Organization address address: GEERT GROOTEPLEIN NOORD 9 city: NIJMEGEN postcode: 6525 EZ website: www.radboudumc.nl contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	NL (NIJMEGEN)	participant	388˙000.00
16	OSLO UNIVERSITETSSYKEHUS HF OSLO UNIVERSITETSSYKEHUS HF Organization address address: KIRKEVEIEN 166 TARNBYGGET city: OSLO postcode: 450 website: http://www.oslo-universitetssykehus.no contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	NO (OSLO)	participant	374˙887.00
17	UNIVERSITAET ULM UNIVERSITAET ULM Organization address address: HELMHOLTZSTRASSE 16 city: ULM postcode: 89081 website: www.uni-ulm.de contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	DE (ULM)	participant	357˙650.00
18	UNIVERCELL BIOSOLUTIONS SAS UNIVERCELL BIOSOLUTIONS SAS Organization address address: PLACE PIERRE POTIER CENTRE PIERRE POTIER CANCEROPOLE ENTREE B city: TOULOUSE postcode: 31000 website: www.univercell-biosolutions.com contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	FR (TOULOUSE)	participant	353˙000.00
19	HELMHOLTZ ZENTRUM MUENCHEN DEUTSCHES FORSCHUNGSZENTRUM FUER GESUNDHEIT UND UMWELT GMBH HELMHOLTZ ZENTRUM MUENCHEN DEUTSCHES FORSCHUNGSZENTRUM FUER GESUNDHEIT UND UMWELT GMBH Organization address address: INGOLSTADTER LANDSTRASSE 1 city: NEUHERBERG postcode: 85764 website: www.helmholtz-muenchen.de contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	DE (NEUHERBERG)	participant	324˙726.00
20	KING'S COLLEGE LONDON KING'S COLLEGE LONDON Organization address address: STRAND city: LONDON postcode: WC2R 2LS website: www.kcl.ac.uk contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	UK (LONDON)	participant	322˙789.00
21	CARDIFF UNIVERSITY CARDIFF UNIVERSITY Organization address address: NEWPORT ROAD 30-36 city: CARDIFF postcode: CF24 ODE website: www.cardiff.ac.uk contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	UK (CARDIFF)	participant	322˙416.00
22	SLASKI UNIWERSYTET MEDYCZNY W KATOWICACH SLASKI UNIWERSYTET MEDYCZNY W KATOWICACH Organization address address: UL. PONIATOWSKIEGO 15 city: KATOWICE postcode: 40 055 website: www.sum.edu.pl contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	PL (KATOWICE)	participant	312˙700.00
23	MEDIZINISCHE UNIVERSITAT GRAZ MEDIZINISCHE UNIVERSITAT GRAZ Organization address address: AUENBRUGGERPLATZ 2 city: GRAZ postcode: 8036 website: http://www.medunigraz.at contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	AT (GRAZ)	participant	291˙480.00
24	CENTRE HOSPITALIER DE LUXEMBOURG CENTRE HOSPITALIER DE LUXEMBOURG Organization address address: RUE NICOLAS ERNEST BARBLE 4 city: LUXEMBOURG postcode: 1210 website: www.chl.lu contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	LU (LUXEMBOURG)	participant	279˙650.00
25	UNIVERZA V LJUBLJANI UNIVERZA V LJUBLJANI Organization address address: KONGRESNI TRG 12 city: LJUBLJANA postcode: 1000 website: http://www.uni-lj.si contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	SI (LJUBLJANA)	participant	259˙820.00
26	THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD Organization address address: WELLINGTON SQUARE UNIVERSITY OFFICES city: OXFORD postcode: OX1 2JD website: www.ox.ac.uk contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	UK (OXFORD)	participant	106˙000.00
27	UNIVERSITA DEGLI STUDI GABRIELE D'ANNUNZIO DI CHIETI-PESCARA UNIVERSITA DEGLI STUDI GABRIELE D'ANNUNZIO DI CHIETI-PESCARA Organization address address: Via dei Vestini 31 city: CHIETI postcode: 66013 website: www.unich.it contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	IT (CHIETI)	participant	46˙404.00
28	UNITED KINGDOM RESEARCH AND INNOVATION UNITED KINGDOM RESEARCH AND INNOVATION Organization address address: POLARIS HOUSE NORTH STAR AVENUE city: SWINDON postcode: SN2 1FL website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	UK (SWINDON)	participant	19˙423.00
29	UNIVERSITETET I OSLO UNIVERSITETET I OSLO Organization address address: PROBLEMVEIEN 5-7 city: OSLO postcode: 313 website: www.uio.no contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	NO (OSLO)	participant	3˙763.00
30	Eli Lilly and Company Limited Eli Lilly and Company Limited Organization address address: Lilly House, Priestley Road city: Basingstoke postcode: RG24 9NL website: www.lilly.com contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	UK (Basingstoke)	participant	0.00
31	GLAXOSMITHKLINE RESEARCH AND DEVELOPMENT LTD. GLAXOSMITHKLINE RESEARCH AND DEVELOPMENT LTD. Organization address address: Great West Road 980 city: BRENTFORD postcode: TW89GS website: www.gsk.com contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	UK (BRENTFORD)	participant	0.00
32	JDRF INTERNATIONAL JDRF INTERNATIONAL Organization address address: 26 BROADWAY 14TH FLOOR city: NEW YORK postcode: 10004 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	US (NEW YORK)	participant	0.00
33	NOVO NORDISK A/S NOVO NORDISK A/S Organization address address: NOVO ALLE 1 city: BAGSVAERD postcode: 2880 website: www.novonordisk.com contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	DK (BAGSVAERD)	participant	0.00
34	SANOFI-AVENTIS DEUTSCHLAND GMBH SANOFI-AVENTIS DEUTSCHLAND GMBH Organization address address: BRUNINGSTRASSE 50 city: FRANKFURT AM MAIN postcode: 65929 website: www.sanofi.com contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	DE (FRANKFURT AM MAIN)	participant	0.00
35	THE LEONA M. AND HARRY B. HELMSLEY CHARITABLE TRUST THE LEONA M. AND HARRY B. HELMSLEY CHARITABLE TRUST Organization address address: 230 PARK AVENUE SUITE 659 city: NEW YORK postcode: 10169 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	US (NEW YORK)	participant	0.00
36	UNIVERSITE DE LAUSANNE UNIVERSITE DE LAUSANNE Organization address address: Quartier Unil-Centre Bâtiment Unicentre city: LAUSANNE postcode: 1015 website: www.unil.ch contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	CH (LAUSANNE)	participant	0.00

Map

Project objective

Preclinical type 1 diabetes (T1D) research has made important advances in recent years, but less progress has been made in translating findings from in vitro and animal models into effective clinical interventions. INNODIA aims to achieve a breakthrough in the way in which we study T1D to enable us to move closer towards prevention and cure of T1D. To this end, INNODIA joins together the leading European experts from the fields of basic and clinical T1D research, four leading pharmaceutical companies with strong expertise in the discovery and development of diabetes medicines and the two leading public organizations involved in T1D research into one comprehensive collaborative consortium. The clinicians in INNODIA oversee T1D registries and have access to large populations of children and adults with T1D and family members at increased risk of developing the disease. The basic science researchers are experts in beta-cell pathophysiology, immunology, biomarker discovery, bioinformatics, systems biology and clinical trial design. INNODIA will accelerate understanding of T1D through coordinated studies of unique clinical samples and translation-oriented preclinical models. This should deliver novel biomarkers and interventions for testing in appropriately designed trials, to be developed in active collaboration with regulators and patients. INNODIA provides access to unique historical biorepositories and will create the Clinical Sample Network, a clinical EU infrastructure to recruit T1D subjects at diagnosis and at-risk relatives. These individuals will be deep-phenotyped and will provide biosamples, allowing the establishment of a ‘living biobank’ of subjects consented for recall. They will be characterized using standardized clinical, genetic and metabolic phenotyping procedures, including prospective, longitudinal sample collection to facilitate novel biomarker discovery. Diverse biological samples (blood, plasma, serum, urine, stools, etc.) will be collected at

Deliverables

List of deliverables.
Discovery and pre-clinical validation of novel biomarkers of Î²-cell mass, dysfunction and death in human T1D	Documents, reports	2020-03-11 13:00:36
Imaging tool for -cell inflammation/death	Documents, reports	2020-03-11 13:00:36
Discovery and pre-clinical validation of biomarkers of immune activation and regulation in human T1D	Documents, reports	2020-03-11 13:00:37
Launch public website	Websites, patent fillings, videos etc.	2020-02-20 08:30:35
Development of novel approaches for in vivo Î²-cell imaging	Documents, reports	2020-02-20 08:30:35
A comprehensive pan-European research network for the study of the aetiology and prevention of T1D	Documents, reports	2020-02-20 08:30:35
EUnPOD functioning	Documents, reports	2020-02-20 08:30:35
Successful start-up of the project - Kick Off Meeting	Documents, reports	2020-02-20 08:30:35

Take a look to the deliverables list in detail: detailed list of INNODIA deliverables.

Publications

List of publications.
year	authors and title	journal	last update
2019	Johan Verhagen, Norkhairin Yusuf, Emma L. Smith, Emily M. Whettlock, Kerina Naran, Sefina Arif, Mark Peakman Proinsulin peptide promotes autoimmune diabetes in a novel HLA-DR3-DQ2-transgenic murine model of spontaneous disease published pages: 2252-2261, ISSN: 0012-186X, DOI: 10.1007/s00125-019-04994-8	Diabetologia 62/12	2020-03-06
2019	Mireia Ramos-RodrÃguez, Helena Raurell-Vila, Maikel L. Colli, Maria InÃªs Alvelos, Marc Subirana-GranÃ©s, JonÃ s Juan-Mateu, Richard Norris, Jean-Valery Turatsinze, Ernesto S. Nakayasu, Bobbie-Jo M. Webb-Robertson, Jamie R. J. Inshaw, Piero Marchetti, Lorenzo Piemonti, Manel Esteller, John A. Todd, Thomas O. Metz, DÃ©cio L. Eizirik, Lorenzo Pasquali The impact of proinflammatory cytokines on the Î²-cell regulatory landscape provides insights into the genetics of type 1 diabetes published pages: 1588-1595, ISSN: 1061-4036, DOI: 10.1038/s41588-019-0524-6	Nature Genetics 51/11	2020-03-06
2019	Pociot F Capturing residual beta cell function in type 1 diabetes published pages: 28-32, ISSN: 0012-186X, DOI: 10.1007/s00125-018-4768-y	Diabetologia 2019 Jan;62(1)	2020-02-20
2019	Yeo L, Pujol-Autonell I, Baptista R, Eichmann M, Kronenberg-Versteeg D, Heck S, Dolton G, Sewell AK, HÃ¤rkÃ¶nen T, Mikk ML, Toppari J, Veijola R, Knip M, Ilonen J, Peakman M Circulating Î² cell-specific CD8+ T cells restricted by high-risk HLA class I molecules show antigen experience in children with and at risk of type 1 diabetes published pages: , ISSN: 0009-9104, DOI: 10.1111/cei.13391	Clinical and Experimental Immunology 2019 Oct 29	2020-02-20
2019	Boss M, Buitinga M, Jansen TJ, Brom M, Visser EP, Gotthardt M PET-based dosimetry of [68Ga]Ga-NODAGA-exendin-4 in humans, a tracer for beta cell imaging published pages: 112â€“116, ISSN: 0161-5505, DOI: 10.2967/jnumed.119.228627	The Journal of Nuclear Medicine 2020 Jan; 61(1)	2020-02-20
2019	Aashiq H. Mirza, Simranjeet Kaur, Lotte B. Nielsen, Joachim StÃ¸rling, Reza Yarani, Martin Roursgaard, Elisabeth R. Mathiesen, Peter Damm, Jens Svare, Henrik B. Mortensen, Flemming Pociot Breast Milk-Derived Extracellular Vesicles Enriched in Exosomes From Mothers With Type 1 Diabetes Contain Aberrant Levels of microRNAs published pages: , ISSN: 1664-3224, DOI: 10.3389/fimmu.2019.02543	Frontiers in Immunology 10	2020-02-20
2019	Jennie H. M. Yang, Leena Khatri, Marius Mickunas, Evangelia Williams, Danijela Tatovic, Mohammad Alhadj Ali, Philippa Young, Penelope Moyle, Vishal Sahni, Ryan Wang, Rejbinder Kaur, Gillian M. Tannahill, Andrew R. Beaton, Danielle M. Gerlag, Caroline O. S. Savage, Antonella Napolitano Rosen, Frank Waldron-Lynch, Colin M. Dayan, Timothy I. M. Tree Phenotypic Analysis of Human Lymph Nodes in Subjects With New-Onset Type 1 Diabetes and Healthy Individuals by Flow Cytometry published pages: , ISSN: 1664-3224, DOI: 10.3389/fimmu.2019.02547	Frontiers in Immunology 10	2020-02-20
2018	Tine Tesovnik, Jernej Kovac, Tinka Hovnik, Klemen Dovc, NataÅ¡a Bratina, Tadej Battelino, Katarina TrebuÅ¡ak PodkrajÅ¡ek Association of Glycemic Control and Cell Stress With Telomere Attrition in Type 1 Diabetes published pages: 879, ISSN: 2168-6203, DOI: 10.1001/jamapediatrics.2018.1175	JAMA Pediatrics 172/9	2020-02-20
2020	StÃ©phane Demine, Andrea Alex Schiavo, Sandra MarÃn-CaÃ±as, Piero Marchetti, Miriam Cnop, Decio L. Eizirik Pro-inflammatory cytokines induce cell death, inflammatory responses, and endoplasmic reticulum stress in human iPSC-derived beta cells published pages: , ISSN: 1757-6512, DOI: 10.1186/s13287-019-1523-3	Stem Cell Research & Therapy 11/1	2020-02-20
2019	Laura Nigi, Carla Maccora, Francesco Dotta, Guido Sebastiani From immunohistological to anatomical alterations of human pancreas in type 1 diabetes: New concepts on the stage published pages: , ISSN: 1520-7552, DOI: 10.1002/dmrr.3264	Diabetes/Metabolism Research and Reviews	2020-02-20
2019	Giuseppina Emanuela Grieco, Noemi Brusco, Giada Licata, Laura Nigi, Caterina Formichi, Francesco Dotta, Guido Sebastiani Targeting microRNAs as a Therapeutic Strategy to Reduce Oxidative Stress in Diabetes published pages: 6358, ISSN: 1422-0067, DOI: 10.3390/ijms20246358	International Journal of Molecular Sciences 20/24	2020-02-20
2019	Giuliana Ventriglia, Francesca Mancarella, Guido Sebastiani, Dana P. Cook, Roberto Mallone, Chantal Mathieu, Conny Gysemans, Francesco Dotta miR-409-3p is reduced in plasma and islet immune infiltrates of NOD diabetic mice and is differentially expressed in people with type 1 diabetes published pages: , ISSN: 0012-186X, DOI: 10.1007/s00125-019-05026-1	Diabetologia	2020-02-20
2019	Johan Henriksson, Xi Chen, TomÃ¡s Gomes, Ubaid Ullah, Kerstin B. Meyer, Ricardo Miragaia, Graham Duddy, Jhuma Pramanik, Kosuke Yusa, Riitta Lahesmaa, Sarah A. Teichmann Genome-wide CRISPR Screens in T Helper Cells Reveal Pervasive Crosstalk between Activation and Differentiation published pages: 882-896.e18, ISSN: 0092-8674, DOI: 10.1016/j.cell.2018.11.044	Cell 176/4	2020-02-20
2019	Desh Deepak Singh, R. David Hawkins, Riitta Lahesmaa, Subhash K. Tripathi CRISPR/Cas9 guided genome and epigenome engineering and its therapeutic applications in immune mediated diseases published pages: , ISSN: 1084-9521, DOI: 10.1016/j.semcdb.2019.05.007	Seminars in Cell & Developmental Biology	2020-02-20
2019	Raphael Scharfmann, Willem Staels, Olivier Albagli The supply chain of human pancreatic Î² cell lines published pages: 3511-3520, ISSN: 0021-9738, DOI: 10.1172/jci129484	Journal of Clinical Investigation 129/9	2020-02-20
2019	Yue Ruan, Ruben H. Willemsen, Malgorzata E. Wilinska, Martin Tauschmann, David B. Dunger, Roman Hovorka Mixedâ€meal tolerance test to assess residual betaâ€cell secretion: Beyond the areaâ€underâ€curve of plasma Câ€peptide concentration published pages: 282-285, ISSN: 1399-543X, DOI: 10.1111/pedi.12816	Pediatric Diabetes 20/3	2020-02-20
2019	Isabella Piga, Bram Heijs, Simone Nicolardi, Laura Giusti, Lorella Marselli, Piero Marchetti, Maria Rosa Mazzoni, Antonio Lucacchini, Liam A. McDonnell Ultra-high resolution MALDI-FTICR-MSI analysis of intact proteins in mouse and human pancreas tissue published pages: 10-16, ISSN: 1387-3806, DOI: 10.1016/j.ijms.2017.11.001	International Journal of Mass Spectrometry 437	2020-02-20
2018	Laura Nigi, Giuseppina Grieco, Giuliana Ventriglia, Noemi Brusco, Francesca Mancarella, Caterina Formichi, Francesco Dotta, Guido Sebastiani MicroRNAs as Regulators of Insulin Signaling: Research Updates and Potential Therapeutic Perspectives in Type 2 Diabetes published pages: 3705, ISSN: 1422-0067, DOI: 10.3390/ijms19123705	International Journal of Molecular Sciences 19/12	2020-02-20
2018	Marco Bugliani, Farooq Syed, Flavia M.M. Paula, Bilal A. Omar, Mara Suleiman, Sandra Mossuto, Francesca Grano, Francesco Cardarelli, Ugo Boggi, Fabio Vistoli, Franco Filipponi, Paolo De Simone, Lorella Marselli, Vincenzo De Tata, Bo Ahren, Decio L. Eizirik, Piero Marchetti DPP-4 is expressed in human pancreatic beta cells and its direct inhibition improves beta cell function and survival in type 2 diabetes published pages: 186-193, ISSN: 0303-7207, DOI: 10.1016/j.mce.2018.01.019	Molecular and Cellular Endocrinology 473	2020-02-20
2017	Christina Reinauer, Esther Bollow, Elke FrÃ¶hlich-Reiterer, Katharina Laubner, Dominik Bergis, Christof SchÃ¶fl, Hans-Peter Kempe, Michael Hummel, Pia Hennes, Katja Gollisch, Holger Haberland, Nicolin Datz, Thomas Meissner, Reinhard Holl Polycystic Ovary Syndrome (PCOS) in Juvenile and Adult Type 1 Diabetes in a German/Austrian Cohort published pages: 661-668, ISSN: 0947-7349, DOI: 10.1055/s-0043-104701	Experimental and Clinical Endocrinology & Diabetes 125/10	2020-02-20
2019	Diego Balboa, Rashmi B. Prasad, Leif Groop, Timo Otonkoski Genome editing of human pancreatic beta cell models: problems, possibilities and outlook published pages: 1329-1336, ISSN: 0012-186X, DOI: 10.1007/s00125-019-4908-z	Diabetologia 62/8	2020-02-20
2019	Fabio Arturo Grieco, Andrea Alex Schiavo, Flora Brozzi, Jonas Juan-Mateu, Marco Bugliani, Piero Marchetti, DÃ©cio Eizirik The microRNAs miR-211-5p and miR-204-5p modulate ER stress in human beta cells published pages: , ISSN: 0952-5041, DOI: 10.1530/jme-19-0066	Journal of Molecular Endocrinology	2020-02-20
2018	Nicole Prinz, Anke Schwandt, Marianne Becker, Christian Denzer, Monika Flury, Maria Fritsch, Angela Galler, Andreas Lemmer, Matthias Papsch, Thomas Reinehr, Joachim Rosenbauer, Reinhard W. Holl Trajectories of Body Mass Index from Childhood to Young Adulthood among Patients with Type 1 Diabetesâ€”A Longitudinal Group-Based Modeling Approach Based on the DPV Registry published pages: 78-85.e4, ISSN: 0022-3476, DOI: 10.1016/j.jpeds.2018.05.014	The Journal of Pediatrics 201	2020-02-20
2019	Niina LietzÃ©n, Karoliina Hirvonen, Anni Honkimaa, Tanja Buchacher, Jutta E. Laiho, Sami Oikarinen, Magdalena A. Mazur, Malin FlodstrÃ¶m-Tullberg, Eric Dufour, Amir-Babak Sioofy-Khojine, Heikki HyÃ¶ty, Riitta Lahesmaa Coxsackievirus B Persistence Modifies the Proteome and the Secretome of Pancreatic Ductal Cells published pages: 340-357, ISSN: 2589-0042, DOI: 10.1016/j.isci.2019.07.040	iScience 19	2020-02-20
2019	Subhash K. Tripathi, Tommi VÃ¤likangas, Ankitha Shetty, Mohd Moin Khan, Robert Moulder, Santosh D. Bhosale, Elina Komsi, Verna Salo, Rafael Sales De Albuquerque, Omid Rasool, Sanjeev Galande, Laura L. Elo, Riitta Lahesmaa Quantitative Proteomics Reveals the Dynamic Protein Landscape during Initiation of Human Th17 Cell Polarization published pages: 334-355, ISSN: 2589-0042, DOI: 10.1016/j.isci.2018.12.020	iScience 11	2020-02-20
2018	Barbara Bohn, Kirsten MÃ¶nkemÃ¶ller, DÃ¶rte Hilgard, Axel Dost, Karl Otfried Schwab, Eggert Lilienthal, Elke Hammer, Kathrin Hake, Maria Fritsch, Bettina Gohlke, Carine de Beaufort, Reinhard W Holl Oral contraception in adolescents with type 1 diabetes and its association with cardiovascular risk factors. A multicenter DPV study on 24 011 patients from Germany, Austria or Luxembourg published pages: 937-944, ISSN: 1399-543X, DOI: 10.1111/pedi.12656	Pediatric Diabetes 19/5	2020-02-20
2019	MaikelÂ L. Colli, FlaviaÂ M. Paula, Lorella Marselli, Piero Marchetti, Merja Roivainen, DecioÂ L. Eizirik, Anne OpÂ deÂ beeck Coxsackievirus B Tailors the Unfolded Protein Response to Favour Viral Amplification in Pancreatic Î² Cells published pages: 375-390, ISSN: 1662-811X, DOI: 10.1159/000496034	Journal of Innate Immunity 11/4	2020-02-20
2019	Pamela L. Toledo, Juha M. Torkko, Andreas MÃ¼ller, Carolin Wegbrod, Anke SÃ¶nmez, Michele Solimena, Mario R. ErmÃ¡cora ICA512 RESP18 homology domain is a protein-condensing factor and insulin fibrillation inhibitor published pages: 8564-8576, ISSN: 0021-9258, DOI: 10.1074/jbc.ra119.007607	Journal of Biological Chemistry 294/21	2020-02-20
2018	Daniel J. DeSalvo, Kellee M. Miller, Julia M. Hermann, David M. Maahs, Sabine E. Hofer, Mark A. Clements, Eggert Lilienthal, Jennifer L. Sherr, Martin Tauschmann, Reinhard W. Holl Continuous glucose monitoring and glycemic control among youth with type 1 diabetes: International comparison from the T1D Exchange and DPV Initiative published pages: 1271-1275, ISSN: 1399-543X, DOI: 10.1111/pedi.12711	Pediatric Diabetes 19/7	2020-02-20
2019	Mijke Buitinga, Tom Jansen, Inge van der Kroon, Wietske Woliner-van der Weg, Marti Boss, Marcel Janssen, Erik Aarntzen, Martin BÃ©hÃ©, Damian Wild, Eric Visser, Maarten Brom, Martin Gotthardt Succinylated Gelatin Improves the Theranostic Potential of Radiolabeled Exendin-4 in Insulinoma Patients published pages: 812-816, ISSN: 0161-5505, DOI: 10.2967/jnumed.118.219980	Journal of Nuclear Medicine 60/6	2020-02-20
2017	Anke Schwandt, Julia M. Hermann, Joachim Rosenbauer, Claudia Boettcher, DÃ©sirÃ©e Dunstheimer, JÃ¼rgen Grulich-Henn, Oliver Kuss, Birgit Rami-Merhar, Christian Vogel, Reinhard W. Holl Longitudinal Trajectories of Metabolic Control From Childhood to Young Adulthood in Type 1 Diabetes From a Large German/Austrian Registry: A Group-Based Modeling Approach published pages: 309-316, ISSN: 0149-5992, DOI: 10.2337/dc16-1625	Diabetes Care 40/3	2020-02-20
2018	Stefanie Lanzinger, Joachim Rosenbauer, Dorothea Sugiri, Tamara Schikowski, Birgit Treiber, Daniela Klee, Wolfgang Rathmann, Reinhard W. Holl Impact of long-term air pollution exposure on metabolic control in children and adolescents with type 1 diabetes: results from the DPV registry published pages: 1354-1361, ISSN: 0012-186X, DOI: 10.1007/s00125-018-4580-8	Diabetologia 61/6	2020-02-20
2018	Anke Schwandt, Dominik Bergis, Michael Denkinger, Katja S.C. Gollisch, Dirk Sandig, Harald Stingl, Stefan Zimny, Reinhard W. Holl Risk factors for decline in renal function among young adults with type 1 diabetes published pages: 940-946, ISSN: 1056-8727, DOI: 10.1016/j.jdiacomp.2018.07.007	Journal of Diabetes and its Complications 32/10	2020-02-20
2019	Niels H. Birkebaek, Julia M. Hermann, Lena Hanberger, Dimitrios Charalampopoulos, Reinhard W. Holl, Torild Skrivarhaug, Karin Aakesson, Justin T. Warner, Ann K. Drivvoll, Ann-Marie Svensson, Terence Stephenson, Sabine E. Hofer, Siri Fredheim, Siv J. Kummernes, Rakesh Amin, Birgit Rami-Merhar, Anders Johansen, Thomas M. Kapellen, Doerte Hilgard, Knut Dahl-JÃ¸rgensen, Elke Froehlich-Reiterer, Maria Center Size and Glycemic Control: An International Study With 504 Centers From Seven Countries published pages: e37-e39, ISSN: 0149-5992, DOI: 10.2337/dc18-1253	Diabetes Care 42/3	2020-02-20
2018	Lorraine Yeo, Alyssa Woodwyk, Sanjana Sood, Anna Lorenc, Martin Eichmann, Irma Pujol-Autonell, Rosella Melchiotti, Ania Skowera, Efthymios Fidanis, Garry M. Dolton, Katie Tungatt, Andrew K. Sewell, Susanne Heck, Alka Saxena, Craig A. Beam, Mark Peakman Autoreactive T effector memory differentiation mirrors Î² cell function in type 1 diabetes published pages: 3460-3474, ISSN: 0021-9738, DOI: 10.1172/JCI120555	Journal of Clinical Investigation 128/8	2020-02-20
2016	Fabio Arturo Grieco, Guido Sebastiani, Jonas Juan-Mateu, Olatz Villate, Laura Marroqui, Laurence LadriÃ¨re, Ksenya Tugay, Romano Regazzi, Marco Bugliani, Piero Marchetti, Francesco Dotta, DÃ©cio L. Eizirik MicroRNAs miR-23a-3p, miR-23b-3p, and miR-149-5p Regulate the Expression of Proapoptotic BH3-Only Proteins DP5 and PUMA in Human Pancreatic Î²-Cells published pages: 100-112, ISSN: 0012-1797, DOI: 10.2337/db16-0592	Diabetes 66/1	2020-02-20
2017	Kira Meyerovich, Natalia M. Violato, Makiko Fukaya, Violette Dirix, Nathalie Pachera, Lorella Marselli, Piero Marchetti, Andreas Strasser, Decio L. Eizirik, Alessandra K. Cardozo MCL-1 Is a Key Antiapoptotic Protein in Human and Rodent Pancreatic Î²-Cells published pages: 2446-2458, ISSN: 0012-1797, DOI: 10.2337/db16-1252	Diabetes 66/9	2020-02-20
2017	James Harbige, Martin Eichmann, Mark Peakman New insights into non-conventional epitopes as T cell targets: The missing link for breaking immune tolerance in autoimmune disease? published pages: 12-20, ISSN: 0896-8411, DOI: 10.1016/j.jaut.2017.08.001	Journal of Autoimmunity 84	2020-02-20
2018	Mijke Buitinga, AÃ¯sha Callebaut, Fernanda Marques CÃ¢mara SodrÃ©, Inne CrÃ¨vecoeur, Gabriele Blahnik-Fagan, Mei-Ling Yang, Marco Bugliani, David Arribas-Layton, Meghan MarrÃ©, Dana P. Cook, Etienne Waelkens, Roberto Mallone, Jon D. Piganelli, Piero Marchetti, Mark J. Mamula, Rita Derua, Eddie A. James, Chantal Mathieu, Lut Overbergh Inflammation-Induced Citrullinated Glucose-Regulated Protein 78 Elicits Immune Responses in Human Type 1 Diabetes published pages: 2337-2348, ISSN: 0012-1797, DOI: 10.2337/db18-0295	Diabetes 67/11	2020-02-20
2017	Daniel A. Cunha, Monia Cito, Fabio Arturo Grieco, Cristina Cosentino, Tatiana Danilova, Laurence LadriÃ¨re, Maria Lindahl, Andrii Domanskyi, Marco Bugliani, Piero Marchetti, DÃ©cio L. Eizirik, Miriam Cnop Pancreatic Î²-cell protection from inflammatory stress by the endoplasmic reticulum proteins thrombospondin 1 and mesencephalic astrocyte-derived neutrotrophic factor (MANF) published pages: 14977-14988, ISSN: 0021-9258, DOI: 10.1074/jbc.M116.769877	Journal of Biological Chemistry 292/36	2020-02-20
2017	Laura Marroqui, Reinaldo S. Dos Santos, Anne Op de beeck, Alexandra Coomans de BrachÃ¨ne, Lorella Marselli, Piero Marchetti, Decio L. Eizirik Interferon-Î± mediates human beta cell HLA class I overexpression, endoplasmic reticulum stress and apoptosis, three hallmarks of early human type 1 diabetes published pages: 656-667, ISSN: 0012-186X, DOI: 10.1007/s00125-016-4201-3	Diabetologia 60/4	2020-02-20
2017	Inne CrÃ¨vecoeur, Saurabh Vig, Chantal Mathieu, Lut Overbergh Understanding type 1 diabetes through proteomics published pages: 571-580, ISSN: 1478-9450, DOI: 10.1080/14789450.2017.1345633	Expert Review of Proteomics 14/7	2020-02-20
2017	Reinaldo S Dos Santos, Laura Marroqui, Fabio A Grieco, Lorella Marselli, Mara Suleiman, Stefan R Henz, Piero Marchetti, Rasmus Wernersson, Decio L Eizirik Protective Role of Complement C3 Against Cytokine-Mediated Î²-Cell Apoptosis published pages: 2503-2521, ISSN: 0013-7227, DOI: 10.1210/en.2017-00104	Endocrinology 158/8	2020-02-20
2018	Slobodan Culina, Ana Ines Lalanne, Georgia Afonso, Karen Cerosaletti, Sheena Pinto, Guido Sebastiani, Klaudia Kuranda, Laura Nigi, Anne Eugster, Thomas Ã˜sterbye, Alicia Maugein, James E. McLaren, Kristin Ladell, Etienne Larger, Jean-Paul Beressi, Anna Lissina, Victor Appay, Howard W. Davidson, SÃ¸ren Buus, David A. Price, Matthias Kuhn, Ezio Bonifacio, Manuela Battaglia, Sophie Caillat-Zucman, Francesco Dotta, Raphael Scharfmann, Bruno Kyewski, Roberto Mallone Islet-reactive CD8 + T cell frequencies in the pancreas, but not in blood, distinguish type 1 diabetic patients from healthy donors published pages: eaao4013, ISSN: 2470-9468, DOI: 10.1126/sciimmunol.aao4013	Science Immunology 3/20	2020-02-20
2018	Niina LietzÃ©n, Lu Cheng, Robert Moulder, Heli Siljander, Essi Laajala, Taina HÃ¤rkÃ¶nen, Aleksandr Peet, Aki Vehtari, Vallo Tillmann, Mikael Knip, Harri LÃ¤hdesmÃ¤ki, Riitta Lahesmaa Characterization and non-parametric modeling of the developing serum proteome during infancy and early childhood published pages: , ISSN: 2045-2322, DOI: 10.1038/s41598-018-24019-5	Scientific Reports 8/1	2020-02-20
2018	Ruben H Willemsen, Keith Burling, Peter Barker, Fran Ackland, Renuka P Dias, Julie Edge, Anne Smith, John Todd, Boryana Lopez, Adrian P Mander, Catherine Guy, David B Dunger Frequent Monitoring of C-Peptide Levels in Newly Diagnosed Type 1 Subjects Using Dried Blood Spots Collected at Home published pages: 3350-3358, ISSN: 0021-972X, DOI: 10.1210/jc.2018-00500	The Journal of Clinical Endocrinology & Metabolism 103/9	2020-02-20
2018	Pia Leete, Roberto Mallone, Sarah J. Richardson, Jay M. Sosenko, Maria J. Redondo, Carmella Evans-Molina The Effect of Age on the Progression and Severity of Type 1 Diabetes: Potential Effects on Disease Mechanisms published pages: , ISSN: 1534-4827, DOI: 10.1007/s11892-018-1083-4	Current Diabetes Reports 18/11	2020-02-20
2018	Alexandra Coomans de BrachÃ¨ne, Reinaldo S. Dos Santos, Laura Marroqui, Maikel L. Colli, Lorella Marselli, Raghavendra G. Mirmira, Piero Marchetti, Decio L. Eizirik IFN-Î± induces a preferential long-lasting expression of MHC class I in human pancreatic beta cells published pages: 636-640, ISSN: 0012-186X, DOI: 10.1007/s00125-017-4536-4	Diabetologia 61/3	2020-02-20
2018	Flavia M. M. Paula, Nayara C. Leite, Patricia C. Borck, Ricardo Freitas-Dias, Miriam Cnop, Mara P. T. Chacon-Mikahil, Claudia R. Cavaglieri, Piero Marchetti, Antonio C. Boschero, Claudio C. Zoppi, Decio L. Eizirik Exercise training protects human and rodent Î² cells against endoplasmic reticulum stress and apoptosis published pages: 1524-1536, ISSN: 0892-6638, DOI: 10.1096/fj.201700710R	The FASEB Journal 32/3	2020-02-20
2017	Miriam Cnop, Tomasz Klupa, Nikolaos Tentolouris, Anna Novials, RÃ©my Burcelin, Mischa van Eimeren Europe has to step up its efforts to produce innovative and safe diabetes technology published pages: 2532-2533, ISSN: 0012-186X, DOI: 10.1007/s00125-017-4455-4	Diabetologia 60/12	2020-02-20
2018	Francesco Dotta, Giuliana Ventriglia, Isaac V. Snowhite, Alberto Pugliese MicroRNAs published pages: 237-245, ISSN: 1752-296X, DOI: 10.1097/MED.0000000000000420	Current Opinion in Endocrinology & Diabetes and Obesity 25/4	2020-02-20
2017	Alexander Balhuizen, Sam Massa, Iris Mathijs, Jean-Valery Turatsinze, Jens De Vos, StÃ©phane Demine, Catarina Xavier, Olatz Villate, Isabelle Millard, Dominique Egrise, Carmen Capito, RaphaÃ«l Scharfmann, Pieter Inâ€™t Veld, Piero Marchetti, Serge Muyldermans, Serge Goldman, Tony Lahoutte, Luc Bouwens, Decio L. Eizirik, Nick Devoogdt A nanobody-based tracer targeting DPP6 for non-invasive imaging of human pancreatic endocrine cells published pages: , ISSN: 2045-2322, DOI: 10.1038/s41598-017-15417-2	Scientific Reports 7/1	2020-02-20
2018	JonÃ s Juan-Mateu, Maria InÃªs Alvelos, Jean-ValÃ©ry Turatsinze, Olatz Villate, Esther Lizarraga-Mollinedo, Fabio Arturo Grieco, Laura MarroquÃ, Marco Bugliani, Piero Marchetti, DÃ©cio L. Eizirik SRp55 Regulates a Splicing Network That Controls Human Pancreatic Î²-Cell Function and Survival published pages: 423-436, ISSN: 0012-1797, DOI: 10.2337/db17-0736	Diabetes 67/3	2020-02-20
2018	Sergio Gonzalez-Duque, Marie Eliane Azoury, Maikel L. Colli, Georgia Afonso, Jean-Valery Turatsinze, Laura Nigi, Ana Ines Lalanne, Guido Sebastiani, Alexia CarrÃ©, Sheena Pinto, Slobodan Culina, NoÃ©mie Corcos, Marco Bugliani, Piero Marchetti, Mathieu Armanet, Marc Diedisheim, Bruno Kyewski, Lars M. Steinmetz, SÃ¸ren Buus, Sylvaine You, Daniele Dubois-Laforgue, Etienne Larger, Jean-Paul Beressi, Graziella Bruno, Francesco Dotta, Raphael Scharfmann, Decio L. Eizirik, Yann Verdier, Joelle Vinh, Roberto Mallone Conventional and Neo-antigenic Peptides Presented by Î² Cells Are Targeted by Circulating NaÃ¯ve CD8+ T Cells in Type 1 Diabetic and Healthy Donors published pages: 946-960.e6, ISSN: 1550-4131, DOI: 10.1016/j.cmet.2018.07.007	Cell Metabolism 28/6	2020-02-20
2018	Maikel L. Colli, Jessica L.E. Hill, Laura MarroquÃ, Jessica Chaffey, Reinaldo S. Dos Santos, Pia Leete, Alexandra Coomans de BrachÃ¨ne, Flavia M.M. Paula, Anne Op de Beeck, Angela Castela, Lorella Marselli, Lars Krogvold, Knut Dahl-Jorgensen, Piero Marchetti, Noel G. Morgan, Sarah J. Richardson, DÃ©cio L. Eizirik PDL1 is expressed in the islets of people with type 1 diabetes and is up-regulated by interferons-Î± and-Î³ via IRF1 induction published pages: 367-375, ISSN: 2352-3964, DOI: 10.1016/j.ebiom.2018.09.040	EBioMedicine 36	2020-02-20
2018	StÃ©phane Demine, Alexander Balhuizen, Vinciane Debaille, Lieke Joosten, MaÃ¯tÃ© Fereau, Satya Chilla, Isabelle Millard, RaphaÃ«l Scharfmann, Dominique Egrise, Serge Goldman, Piero Marchetti, Martin Gotthardt, Sophie Laurent, Carmen Burtea, Decio Eizirik Imaging of Human Insulin Secreting Cells with Gd-DOTA-P88, a Paramagnetic Contrast Agent Targeting the Beta Cell Biomarker FXYD2Î³a published pages: 2100, ISSN: 1420-3049, DOI: 10.3390/molecules23092100	Molecules 23/9	2020-02-20
2018	Maria InÃªs Alvelos, JonÃ s Juan-Mateu, Maikel Luis Colli, Jean-ValÃ©ry Turatsinze, DÃ©cio L. Eizirik When one becomes many-Alternative splicing in Î²-cell function and failure published pages: 77-87, ISSN: 1462-8902, DOI: 10.1111/dom.13388	Diabetes, Obesity and Metabolism 20	2020-02-20
2018	Emily K. Sims, Carmella Evans-Molina, Sarah A. Tersey, Decio L. Eizirik, Raghavendra G. Mirmira Biomarkers of islet beta cell stress and death in type 1 diabetes published pages: 2259-2265, ISSN: 0012-186X, DOI: 10.1007/s00125-018-4712-1	Diabetologia 61/11	2020-02-20
2018	Chantal Mathieu, Riitta Lahesmaa, Ezio Bonifacio, Peter Achenbach, Timothy Tree Immunological biomarkers for the development and progression of type 1 diabetes published pages: 2252-2258, ISSN: 0012-186X, DOI: 10.1007/s00125-018-4726-8	Diabetologia 61/11	2020-02-20
2018	Diego Balboa, Jonna SaarimÃ¤ki-Vire, Daniel Borshagovski, Mantas Survila, PÃ¤ivi Lindholm, Emilia Galli, Solja Eurola, Jarkko Ustinov, Heli Grym, Hanna Huopio, Juha Partanen, Kirmo Wartiovaara, Timo Otonkoski Insulin mutations impair beta-cell development in a patient-derived iPSC model of neonatal diabetes published pages: , ISSN: 2050-084X, DOI: 10.7554/elife.38519	eLife 7	2020-02-20
2018	Reinaldo S. Dos Santos, Laura Marroqui, Teresa Velayos, Ane Olazagoitia-Garmendia, Amaia Jauregi-Miguel, Ainara Castellanos-Rubio, Decio L. Eizirik, Luis CastaÃ±o, Izortze Santin DEXI, a candidate gene for type 1 diabetes, modulates rat and human pancreatic beta cell inflammation via regulation of the type I IFN/STAT signalling pathway published pages: , ISSN: 0012-186X, DOI: 10.1007/s00125-018-4782-0	Diabetologia	2020-02-20
2017	Christina Reinauer, Joachim Rosenbauer, Christina BÃ¤chle, Christian Herder, Michael Roden, Sian Ellard, Elisa De Franco, Beate Karges, Reinhard Holl, JÃ¼rgen Enczmann, Thomas Meissner The Clinical Course of Patients with Preschool Manifestation of Type 1 Diabetes Is Independent of the HLA DR-DQ Genotype published pages: 146, ISSN: 2073-4425, DOI: 10.3390/genes8050146	Genes 8/5	2020-02-20
2018	Denise MÃ¼ller, Tanja Telieps, Anne Eugster, Christina Weinzierl, Manja Jolink, Anette-Gabriele Ziegler, Ezio Bonifacio Novel minor HLA DR associated antigens in type 1 diabetes published pages: 87-91, ISSN: 1521-6616, DOI: 10.1016/j.clim.2018.07.001	Clinical Immunology 194	2020-02-20
2018	Piero Marchetti, Mara Suleiman, Lorella Marselli Organ donor pancreases for the study of human islet cell histology and pathophysiology: a precious and valuable resource published pages: 770-774, ISSN: 0012-186X, DOI: 10.1007/s00125-018-4546-x	Diabetologia 61/4	2020-02-20
2018	Masaya Oshima, Klaus-Peter Knoch, Marc Diedisheim, Antje Petzold, Pierre Cattan, Marco Bugliani, Piero Marchetti, Pratik Choudhary, Guo-Cai Huang, Stefan R. Bornstein, Michele Solimena, Olivier Albagli-Curiel, Raphael Scharfmann Virus-like infection induces human Î² cell dedifferentiation published pages: , ISSN: 2379-3708, DOI: 10.1172/jci.insight.97732	JCI Insight 3/3	2020-02-20
2018	Elina Hakonen, Vikash Chandra, Christopher L. Fogarty, Nancy Yiu-Lin Yu, Jarkko Ustinov, Shintaro Katayama, Emilia Galli, Tatiana Danilova, PÃ¤ivi Lindholm, Aki Vartiainen, Elisabet Einarsdottir, Kaarel KrjutÅ¡kov, Juha Kere, Mart Saarma, Maria Lindahl, Timo Otonkoski MANF protects human pancreatic beta cells against stress-induced cell death published pages: 2202-2214, ISSN: 0012-186X, DOI: 10.1007/s00125-018-4687-y	Diabetologia 61/10	2020-02-20

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