Explore the words cloud of the PALE-Blu project. It provides you a very rough idea of what is the project "PALE-Blu" about.
The following table provides information about the project.
Coordinator |
THE UNIVERSITY OF NOTTINGHAM
Organization address contact info |
Coordinator Country | United Kingdom [UK] |
Project website | http://www.palebludata.com/ |
Total cost | 6˙039˙301 € |
EC max contribution | 6˙039˙301 € (100%) |
Programme |
1. H2020-EU.3.2.1.1. (Increasing production efficiency and coping with climate change, while ensuring sustainability and resilience) |
Code Call | H2020-SFS-2016-2 |
Funding Scheme | RIA |
Starting year | 2017 |
Duration (year-month-day) | from 2017-06-01 to 2020-11-30 |
Take a look of project's partnership.
New outbreaks caused by bluetongue viruses (BTVs) have emerged in European livestock every year since 1998. These events that have been linked to climate change, resulted in massive losses due to fatalities, reduced productivity, reproductive failures, restricted animal movements/trade, and surveillance/vaccination costs. PALE-Blu brings together European institutes with expertise in BTV research and diagnosis, with partners in endemic regions (Africa, the Middle East and Turkey) that act as a ‘source’ for BTV strains that emerge in Europe. Full-genome sequence-analyses will increase the accuracy of BTV-strain distribution maps, to identify pathways and mechanisms for spread into and within Europe, as well as appropriate prevention strategies. PALE-Blu will analyse the genetic connectivity of Culicoides vector populations in different regions, as well as the movements of individual BTV lineages and genes. Together with reverse genetics technologies and infection/replication studies in new Culicoides cell lines, or adults from different Culicoides species, this will elucidate the genetic basis for geographic localisation/movement of BTV strains and serotypes. We will analyse differences in saliva proteins from Culicoides species, their ability to modify the BTV surface proteins (proteases) and effects on efficiency of transmission (in both directions) between vertebrae hosts and insect-vectors. These studies will provide a better understanding of incursion risks for different BTV strains, supporting effective control strategies. PALE-BLU will explore more effective and cross-serotype subunit-vaccines that are DIVA assay compatible and generate a stronger immune response from a single innoculation. We will also explore the potential for use of antiviral agents to induce immediate protection post vaccination. More effective diagnostic systems to better detect mixed infections will also be developed by multiplexing existing or novel diagnostic assay systems.
Spatial data base of vector distributions | Other | 2020-02-25 15:30:00 |
Adaptation and maintenance of spatial data website to include PALE-Blu data | Websites, patent fillings, videos etc. | 2020-02-25 15:29:59 |
Serotype specific qRT-PCR for novel BTV serotypes | Documents, reports | 2020-02-25 15:29:59 |
Project website | Websites, patent fillings, videos etc. | 2020-02-25 15:29:59 |
Reassortant strains between conventional and novel / atypical strains | Documents, reports | 2020-02-25 15:30:00 |
Updated website with environment / anthropogenic data | Websites, patent fillings, videos etc. | 2020-02-25 15:30:00 |
Refined spatial epizone maps | Documents, reports | 2020-02-25 15:29:59 |
List of required environmental and landscape factors | Documents, reports | 2020-02-25 15:29:59 |
Assess pathogenesis / horizontal transmission of BTV strains | Documents, reports | 2020-02-25 15:29:59 |
List of spatial data required | Documents, reports | 2020-02-25 15:30:00 |
Take a look to the deliverables list in detail: detailed list of PALE-Blu deliverables.
year | authors and title | journal | last update |
---|---|---|---|
2017 |
V. L. Fowler, E. L. A. Howson, J. Flannery, M. Romito, A. Lubisi, M. Agüero, P. Mertens, C. A. Batten, H. R. Warren, J. Castillo-Olivares Development of a Novel Reverse Transcription Loop-Mediated Isothermal Amplification Assay for the Rapid Detection of African Horse Sickness Virus published pages: 1579-1588, ISSN: 1865-1674, DOI: 10.1111/tbed.12549 |
Transboundary and Emerging Diseases 64/5 | 2020-02-25 |
2016 |
Cristina C. Celma, Meredith Stewart, Kerstin Wernike, Michael Eschbaumer, Lorenzo Gonzalez-Molleda, Emmanuel Breard, Claudia Schulz, Bernd Hoffmann, Andy Haegeman, Kris De Clercq, Stephan Zientara, Piet A. van Rijn, Martin Beer, Polly Roy Replication-Deficient Particles: New Insights into the Next Generation of Bluetongue Virus Vaccines published pages: , ISSN: 0022-538X, DOI: 10.1128/JVI.01892-16 |
Journal of Virology 91/1 | 2020-02-25 |
2017 |
Maude Jacquot, Kyriaki Nomikou, Massimo Palmarini, Peter Mertens, Roman Biek Bluetongue virus spread in Europe is a consequence of climatic, landscape and vertebrate host factors as revealed by phylogeographic inference published pages: 20170919, ISSN: 0962-8452, DOI: 10.1098/rspb.2017.0919 |
Proceedings of the Royal Society B: Biological Sciences 284/1864 | 2020-02-25 |
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The information about "PALE-BLU" are provided by the European Opendata Portal: CORDIS opendata.
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