Essential role of protein modification by members of the Ubiquitin family: Post-translational modifications (PTM) by members of the Ubiquitin (Ub) family represent an efficient way to regulate protein function at several levels: to change their localisation, activity, their interaction with partner proteins or their stability at the right time and cellular compartment, according to the cell requirements. Defects in this homeostatic equilibrium result in pathologies such as cancer, neurodegeneration, inflammation or multiple infections. For this reason, this research area has become very attractive for fundamental scientists as well as for the pharmaceutical industry aiming to identify potential targets for therapeutic intervention. Ub family members hold a homeostatic equilibrium within the cell and are interconnected in various ways including the regulation of enzymes that control the modified status of target proteins. Interestingly, Ub and Ub-like (UbL) proteins can modify themselves, forming intricate and complex chains. This landscape has recently expanded with the discovery of the formation of heterologous chains among UbL molecules including SUMO or NEDD8 but also other PTMs such as phosphorylation or acetylation. This unsuspected complexity of what is now known as the «Ubiquitin Code», which is an unknown universal language that needs to be deciphered to understand protein homeostasis and its associated pathologies. To decrypt this complex code requires joint collaborative multidisciplinary efforts at all levels, including the use of distinct molecular systems and model organisms and the latest technological developments to explore chemical, biochemical, molecular, pharmacological and clinical aspects of protein modification by members of the Ub family. UbiCODE represents an unprecedented effort to understand this code in an integrated manner.
Deliverables
List of deliverables.
Supervisory Board
Other
2020-04-16 14:16:31
Outreach and research article publications, meetings, events
Documents, reports
2020-04-16 14:16:26
UbiCODE website launched and updated and presence in social media
Zuzanna Kozicka, Georg Petzold, Nicolas H. Thomä Taking the Brakes Off Targeted Protein Degradation published pages: 16-18, ISSN: 2451-9456, DOI: 10.1016/j.chembiol.2019.12.010
Are you the coordinator (or a participant) of this project? Plaese send me more information about the "UBICODE" project.
For instance: the website url (it has not provided by EU-opendata yet), the logo, a more detailed description of the project (in plain text as a rtf file or a word file), some pictures (as picture files, not embedded into any word file), twitter account, linkedin page, etc.
Send me an email (fabio@fabiodisconzi.com) and I put them in your project's page as son as possible.
Thanks. And then put a link of this page into your project's website.
The information about "UBICODE" are provided by the European Opendata Portal: CORDIS opendata.
More projects from the same programme (H2020-EU.1.3.1.)
ORBITAL (2019)
Ocular Research By Integrated Training And Learning