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PRe-ART SIGNED

Predictive Reagent Antibody Replacement Technology

Total Cost €

EC-Contrib. €

Partnership

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Outcomes and
results

PRe-ART project word cloud

Explore the words cloud of the PRe-ART project. It provides you a very rough idea of what is the project "PRe-ART" about.

encyclopedia citizen mabs antibody evolution closely protein quality antibodies molecules diagnostics diagnostic detection revolution disrupt medical ultimately enabled joint modular combined prediction industry computational predictive science completely animal entirely forty replace fashion designed biological bricks generate engineering myriad commercial market experiment capability create selling replacement multidisciplinary bind vision modules breakthrough biotechnological replacements combining components function detect efforts decade basic pis women health correctly 50 directed interdisciplinary platform reagent peptide foundational shown failings monoclonal wellbeing binding experimentally lego designer replaced labs biomolecules course economy conventional life

Project "PRe-ART" data sheet

The following table provides information about the project.

Coordinator	UNIVERSITAT ZURICH Organization address address: RAMISTRASSE 71 city: ZURICH postcode: 8006 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.
Coordinator Country	Switzerland [CH]
Project website	https://www.pre-art.uzh.ch
Total cost	3˙588˙125 €
EC max contribution	3˙588˙125 € (100%)
Programme	1. H2020-EU.1.2.1. (FET Open)
Code Call	H2020-FETOPEN-1-2016-2017
Funding Scheme	RIA
Starting year	2017
Duration (year-month-day)	from 2017-09-01 to 2021-08-31

Partnership

Take a look of project's partnership.

#	participants	country	role	EC contrib. [€]
1	UNIVERSITAT ZURICH UNIVERSITAT ZURICH Organization address address: RAMISTRASSE 71 city: ZURICH postcode: 8006 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	CH (ZURICH)	coordinator	1˙428˙750.00
2	ASTON UNIVERSITY ASTON UNIVERSITY Organization address address: ASTON TRIANGLE city: BIRMINGHAM postcode: B4 7ET website: www.aston.ac.uk contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	UK (BIRMINGHAM)	participant	1˙189˙375.00
3	UNIVERSITAT BAYREUTH UNIVERSITAT BAYREUTH Organization address address: UNIVERSITATSSTRASSE 30 city: BAYREUTH postcode: 95447 website: www.uni-bayreuth.de contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	DE (BAYREUTH)	participant	970˙000.00

Map

Project objective

Predictive Reagent Antibody Replacement Technology (PRe-ART) will create a foundational new technology platform to completely replace conventional antibody technology within medical diagnostics and basic life science research. In a multidisciplinary approach combining basic science, protein engineering and computational prediction, Pre-ART will generate non-antibody components which can be combined in an entirely modular fashion to create molecules that bind any peptide of choice. Such a biotechnological revolution is timely because of current failings in the reagent antibody market, after forty years still based on monoclonal antibodies (mAbs) to detect biomolecules, when 50% of all commercial reagent mAbs have been shown to not function correctly.

By combining information science with directed evolution, PRe-ART will ultimately create an encyclopedia of pre-designed and experimentally pre-selected modules (like biological Lego bricks) that may be combined, without any further experiment, to generate unique binding molecules that function as antibody replacements. The PRe-ART vision is that mAbs for many applications in biological research will be replaced over the course of a decade by these designer molecules, with the potential to completely disrupt the industry selling low-quality commercial animal-derived reagent antibodies, and thus create a major new technology for biological research.

Thus, PRe-ART will ultimately contribute not only to the health and wellbeing of the EU citizen through improved diagnostic capability, but also to the economy of the EU through the development of myriad detection products, enabled by this foundational platform technology. The interdisciplinary PRe-ART project will achieve this goal by bringing together three leading labs from different fields, two of which are lead by women PIs, whose joint efforts will achieve this breakthrough S&T target. The PRe-ART project thus closely addresses all specific challenges of the call.

Deliverables

List of deliverables.
Project website and logo	Websites, patent fillings, videos etc.	2020-02-27 11:42:50
Two press releases / media actions launched and video online	Other	2020-02-27 11:42:50

Take a look to the deliverables list in detail: detailed list of PRe-ART deliverables.

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The information about "PRE-ART" are provided by the European Opendata Portal: CORDIS opendata.