Opendata, web and dolomites

PolControl SIGNED

Engineering translation machinery to produce light-responsive protein-polymers

Total Cost €

0

EC-Contrib. €

0

Partnership

0

Views

0

 PolControl project word cloud

Explore the words cloud of the PolControl project. It provides you a very rough idea of what is the project "PolControl" about.

universal    trna    evolution    physical    interrogation    directing    azobenzenes    manipulation    overcome    elongation    apparatus    cellular    protein    efforts    structures    acids    identical    classes    deepen    temporal    discovered    chemical    responsive    constitute    synthetic    utilize    photochemical    materials    genomic    natural    self    excludes    chemistry    site    complexity    engineering    machinery    containing    methodology    engineer    generate    hinders    versatile    demand    amino    incorporated    technologies    libraries    biophysical    smart    groups    select    biologically    translation    saas    biomaterials    inadequate    precise    components    macromolecular    biomaterial    multiple    polypeptide    biological    assembly    create    synthesis    limits    function    sequence    formulations    proteins    incorporation    limitation    biology    functional    platform    agents    elucidate    light    marrying    generating    co    cells    visible    extra    azobenzene    direct    spatio    synthetase    precludes    aminoacyl    substituted   

Project "PolControl" data sheet

The following table provides information about the project.

Coordinator
BEN-GURION UNIVERSITY OF THE NEGEV 

Organization address
address: .
city: BEER SHEVA
postcode: 84105
website: www.bgu.ac.il

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Israel [IL]
 Total cost 1˙328˙712 €
 EC max contribution 1˙328˙712 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2017-STG
 Funding Scheme ERC-STG
 Starting year 2017
 Duration (year-month-day) from 2017-11-01   to  2022-10-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    BEN-GURION UNIVERSITY OF THE NEGEV IL (BEER SHEVA) coordinator 1˙328˙712.00

Map

 Project objective

A general and versatile technology to engineer visible light-responsive biological agents will enable spatio-temporal manipulation and interrogation of proteins, pathways, and cells, and the design of “smart” biomaterials that can direct and respond to biological processes on-demand. Site specific incorporation of multiple visible-light-responsive chemical groups at the polypeptide level will constitute a universal methodology for precise production of light-responsive proteins and protein-based materials. However, inadequate engineering of the protein translation apparatus limits the number and complexity of chemical groups that can be incorporated into proteins as synthetic amino acids (sAAs). This limitation precludes the incorporation of recently discovered visible-light-responsive chemical groups, hinders protein engineering efforts, and excludes production of biomaterials in which multiple identical sAAs provide new physical or biophysical properties. We propose to overcome this challenge by generating a genomic-engineering based platform for co-evolution of multiple components of the translation machinery (the aminoacyl tRNA synthetase, tRNA, and elongation factor) to select for cellular machinery capable of multi-site incorporation of highly substituted azobenzenes with a range of biologically relevant photochemical properties. We will then utilize these translation systems to produce libraries of azobenzene-containing protein-based materials to elucidate the sequence-function requirements for directing light-responsive self-assembly of macromolecular structures, and to generate biomaterial formulations for control of various intra- and extra-cellular processes. By developing and marrying technologies in synthetic biology, chemistry, and biomaterials, this study will enable the synthesis of light-responsive proteins, deepen our understanding of natural and evolved translation systems, and create new classes of functional light-responsive biomaterials.

Are you the coordinator (or a participant) of this project? Plaese send me more information about the "POLCONTROL" project.

For instance: the website url (it has not provided by EU-opendata yet), the logo, a more detailed description of the project (in plain text as a rtf file or a word file), some pictures (as picture files, not embedded into any word file), twitter account, linkedin page, etc.

Send me an  email (fabio@fabiodisconzi.com) and I put them in your project's page as son as possible.

Thanks. And then put a link of this page into your project's website.

The information about "POLCONTROL" are provided by the European Opendata Portal: CORDIS opendata.

More projects from the same programme (H2020-EU.1.1.)

HyperBio (2019)

Vis-NIR Hyperspectral imaging for biomaterial quality control

Read More  

NEUTRAMENTH (2018)

A redox-neutral process for the cost-efficient and environmentally friendly production of Menthol

Read More  

OSIRIS (2020)

Automatic measurement of speech understanding using EEG

Read More