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PolControl SIGNED

Engineering translation machinery to produce light-responsive protein-polymers

Total Cost €

0

EC-Contrib. €

0

Partnership

0

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 PolControl project word cloud

Explore the words cloud of the PolControl project. It provides you a very rough idea of what is the project "PolControl" about.

technologies    classes    direct    limitation    amino    smart    biological    elucidate    physical    sequence    select    precludes    apparatus    formulations    precise    genomic    assembly    incorporation    elongation    synthesis    manipulation    discovered    containing    platform    directing    libraries    evolution    visible    natural    cellular    light    generating    identical    saas    proteins    extra    biophysical    biology    incorporated    multiple    marrying    overcome    universal    chemistry    utilize    create    azobenzene    generate    methodology    demand    co    functional    cells    interrogation    chemical    substituted    groups    excludes    spatio    temporal    complexity    biologically    agents    photochemical    efforts    responsive    versatile    synthetase    inadequate    aminoacyl    hinders    engineering    synthetic    site    macromolecular    materials    structures    components    azobenzenes    engineer    translation    polypeptide    biomaterials    constitute    biomaterial    trna    function    protein    limits    machinery    acids    deepen    self   

Project "PolControl" data sheet

The following table provides information about the project.

Coordinator
BEN-GURION UNIVERSITY OF THE NEGEV 

Organization address
address: .
city: BEER SHEVA
postcode: 84105
website: www.bgu.ac.il

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Israel [IL]
 Total cost 1˙328˙712 €
 EC max contribution 1˙328˙712 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2017-STG
 Funding Scheme ERC-STG
 Starting year 2017
 Duration (year-month-day) from 2017-11-01   to  2022-10-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    BEN-GURION UNIVERSITY OF THE NEGEV IL (BEER SHEVA) coordinator 1˙328˙712.00

Map

 Project objective

A general and versatile technology to engineer visible light-responsive biological agents will enable spatio-temporal manipulation and interrogation of proteins, pathways, and cells, and the design of “smart” biomaterials that can direct and respond to biological processes on-demand. Site specific incorporation of multiple visible-light-responsive chemical groups at the polypeptide level will constitute a universal methodology for precise production of light-responsive proteins and protein-based materials. However, inadequate engineering of the protein translation apparatus limits the number and complexity of chemical groups that can be incorporated into proteins as synthetic amino acids (sAAs). This limitation precludes the incorporation of recently discovered visible-light-responsive chemical groups, hinders protein engineering efforts, and excludes production of biomaterials in which multiple identical sAAs provide new physical or biophysical properties. We propose to overcome this challenge by generating a genomic-engineering based platform for co-evolution of multiple components of the translation machinery (the aminoacyl tRNA synthetase, tRNA, and elongation factor) to select for cellular machinery capable of multi-site incorporation of highly substituted azobenzenes with a range of biologically relevant photochemical properties. We will then utilize these translation systems to produce libraries of azobenzene-containing protein-based materials to elucidate the sequence-function requirements for directing light-responsive self-assembly of macromolecular structures, and to generate biomaterial formulations for control of various intra- and extra-cellular processes. By developing and marrying technologies in synthetic biology, chemistry, and biomaterials, this study will enable the synthesis of light-responsive proteins, deepen our understanding of natural and evolved translation systems, and create new classes of functional light-responsive biomaterials.

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The information about "POLCONTROL" are provided by the European Opendata Portal: CORDIS opendata.

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