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iNanoBIT SIGNED

Integration of Nano- and Biotechnology for beta-cell and islet Transplantation

Total Cost €

EC-Contrib. €

Partnership

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Outcomes and
results

iNanoBIT project word cloud

Explore the words cloud of the iNanoBIT project. It provides you a very rough idea of what is the project "iNanoBIT" about.

safe therapies regenerative supplies beta transplants points reinforce patients healthcare perfect chain validated imaging differentiated preclinical tissue monitoring human validate coordinated mr nanotechnologies engraftment develop1 cells porcine combination nanotechnology excellent islets fast humans cellular arrive nano opening multimodality nanomolecules islet transplantable area starting toolbox missing trl6 pancreatic vivo translation industrial scope sme match stem animal ready porcinexenotransplant market inanobit marketing models pet vitro provision trl vital sensitive subsequent supply pluripotent cell translational competitiveness academic clinical levels types body model molecule function technological medicinal optoacoustic technologies sensitivity trials survival proliferation spect

Project "iNanoBIT" data sheet

The following table provides information about the project.

Coordinator	BIOTALENTUM TUDASFEJLESZTO KFT Organization address address: AULICH LAJOS UTCA 26 city: GOEDOELLO postcode: 2100 website: www.biotalentum.hu contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.
Coordinator Country	Hungary [HU]
Project website	http://inanobit.eu/
Total cost	6˙999˙997 €
EC max contribution	6˙999˙997 € (100%)
Programme	1. H2020-EU.2.1.2. (INDUSTRIAL LEADERSHIP - Leadership in enabling and industrial technologies – Nanotechnologies)
Code Call	H2020-NMBP-2017-two-stage
Funding Scheme	RIA
Starting year	2017
Duration (year-month-day)	from 2017-10-01 to 2022-09-30

Partnership

Take a look of project's partnership.

#	participants	country	role	EC contrib. [€]
1	BIOTALENTUM TUDASFEJLESZTO KFT BIOTALENTUM TUDASFEJLESZTO KFT Organization address address: AULICH LAJOS UTCA 26 city: GOEDOELLO postcode: 2100 website: www.biotalentum.hu contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	HU (GOEDOELLO)	coordinator	1˙301˙341.00
2	LUDWIG-MAXIMILIANS-UNIVERSITAET MUENCHEN LUDWIG-MAXIMILIANS-UNIVERSITAET MUENCHEN Organization address address: GESCHWISTER SCHOLL PLATZ 1 city: MUENCHEN postcode: 80539 website: www.uni-muenchen.de contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	DE (MUENCHEN)	participant	1˙629˙575.00
3	Mediso Orvosi Berendezes Fejleszto es Szerviz Kft. Mediso Orvosi Berendezes Fejleszto es Szerviz Kft. Organization address address: ALSOTOROKVESZ 14 city: BUDAPEST postcode: 1022 website: www.mediso.hu contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	HU (BUDAPEST)	participant	795˙375.00
4	BBS NANOTECHNOLOGIA KUTATASI ES FEJLESZTESI KORLATOLT FELELOSSEGU TARSASAG BBS NANOTECHNOLOGIA KUTATASI ES FEJLESZTESI KORLATOLT FELELOSSEGU TARSASAG Organization address address: BOSZORMENYI UT 212 city: DEBRECEN postcode: 4032 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	HU (DEBRECEN)	participant	710˙726.00
5	UNIVERSITA' DEGLI STUDI DI MILANO-BICOCCA UNIVERSITA' DEGLI STUDI DI MILANO-BICOCCA Organization address address: PIAZZA DELL'ATENEO NUOVO 1 city: MILANO postcode: 20126 website: www.unimib.it contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	IT (MILANO)	participant	652˙563.00
6	DEFYMED DEFYMED Organization address address: 8 AVENUE DANTE city: STRASBOURG postcode: 67200 website: www.defymed.com contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	FR (STRASBOURG)	participant	645˙625.00
7	ITHERA MEDICAL GMBH ITHERA MEDICAL GMBH Organization address address: ZIELSTATTSTRASSE 13 city: MUNCHEN postcode: 81379 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	DE (MUNCHEN)	participant	636˙041.00
8	UNIVERSITE CATHOLIQUE DE LOUVAIN UNIVERSITE CATHOLIQUE DE LOUVAIN Organization address address: PLACE DE L UNIVERSITE 1 city: LOUVAIN LA NEUVE postcode: 1348 website: www.uclouvain.be contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	BE (LOUVAIN LA NEUVE)	participant	628˙750.00

Map

Project objective

The iNanoBIT project is aimed to apply nanotechnologies for imaging porcine pancreatic islet cellular transplants and induced pluripotent stem cell-derived beta-cells and subsequent regenerative processes in vivo in a porcine model. The project will develop1) novel highly sensitive nanotechnology-based imaging approaches allowing for monitoring of survival, engraftment, proliferation, function and whole body distribution of the cellular transplants in a preclinical porcine model with excellent translational potential to humans; 2) develop and validate the application of state-of-the-art imaging technologies facilitating the provision of new regenerative therapies to preclinical large animal models and patients; 3) directly contribute to the opening of a new market sector for i) imaging equipment (SPECT, PET/MR, optoacoustic imaging in preclinical large animal models and patients), ii) nano-imaging molecule supplies (nanomolecules allowing multimodality imaging of specific cell types with high sensitivity), iii) validated transplantable in vitro differentiated human beta-cells and porcinexenotransplant islets thus will reinforce the European healthcare supply chain for regenerative medicinal products. The iNanoBIT project will provide the currently missing toolbox for preclinical/clinical testing for a safe translation of regenerative medicinal cellular and tissue products, currently under preclinical and clinical trials, which is vital for the competitiveness of the European healthcare sector in this fast-growing area. The consortium of 5 SME and 3 Academic partners is coordinated and driven by the industrial partners from the field of nanotechnology, imaging and stem cell technologies, providing a perfect match and unique combination addressing the scope and expected impact of the call and providing TRL 3/4 starting points for the key technological elements, and expect to arrive to TRL6 levels of validated technologies ready for marketing by the end of the project.

Publications

List of publications.
year	authors and title	journal	last update
2018	Elisabeth Kemter, Eckhard Wolf Recent progress in porcine islet isolation, culture and engraftment strategies for xenotransplantation published pages: 1, ISSN: 1087-2418, DOI: 10.1097/mot.0000000000000579	Current Opinion in Organ Transplantation	2019-10-30
2018	Elisabeth Kemter, Joachim Denner, Eckhard Wolf Will Genetic Engineering Carry Xenotransplantation of Pig Islets to the Clinic? published pages: , ISSN: 1534-4827, DOI: 10.1007/s11892-018-1074-5	Current Diabetes Reports 18/11	2019-10-30
2019	Susanna Sampaolesi, Francesco Nicotra, Laura Russo Glycans in nanomedicine, impact and perspectives published pages: 43-60, ISSN: 1756-8919, DOI: 10.4155/fmc-2018-0368	Future Medicinal Chemistry 11/1	2019-10-30

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The information about "INANOBIT" are provided by the European Opendata Portal: CORDIS opendata.