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STARSTEM SIGNED

NanoSTARS imaging for STEM cell therapy for arthritic joints

Total Cost €

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EC-Contrib. €

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Partnership

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Outcomes and
results

STARSTEM project word cloud

Explore the words cloud of the STARSTEM project. It provides you a very rough idea of what is the project "STARSTEM" about.

transplanted engraft contrast nanostars plasmonic joints imaging anatomical nanoparticles restorative animal unprecedented sensitive retention detect optical cells clinical modal million mediated animals arthritic engraftment mri advantages hurdles opportunity did arthritis disease small human provides 10 functional majority patients worldwide therapeutic population therapy treatments nanostar sensitivity light magnetic deep symptomatic dual algorithms proposing osteoarthritis stem self proof proposes efficacy inability co time differential monitoring cell oa regeneration finger humans prevalent individual gold harness global designed tracking enhanced registered injured conjugated sound safety pa penetration gaps exploits agent successful starstem cartilage conventional site diagnose organs movement prior depths clinically cure tissue nanomaterial techniques photoacoustic repair

Project "STARSTEM" data sheet

The following table provides information about the project.

Coordinator	NATIONAL UNIVERSITY OF IRELAND GALWAY Organization address address: UNIVERSITY ROAD city: Galway postcode: H91 website: www.nuigalway.ie contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.
Coordinator Country	Ireland [IE]
Project website	http://starstem.eu/
Total cost	5˙933˙952 €
EC max contribution	5˙933˙952 € (100%)
Programme	1. H2020-EU.2.1.2. (INDUSTRIAL LEADERSHIP - Leadership in enabling and industrial technologies – Nanotechnologies)
Code Call	H2020-NMBP-2017-two-stage
Funding Scheme	RIA
Starting year	2018
Duration (year-month-day)	from 2018-01-01 to 2021-12-31

Partnership

Take a look of project's partnership.

#	participants	country	role	EC contrib. [€]
1	NATIONAL UNIVERSITY OF IRELAND GALWAY NATIONAL UNIVERSITY OF IRELAND GALWAY Organization address address: UNIVERSITY ROAD city: Galway postcode: H91 website: www.nuigalway.ie contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	IE (Galway)	coordinator	1˙989˙565.00
2	UNIVERSITA DEGLI STUDI DI GENOVA UNIVERSITA DEGLI STUDI DI GENOVA Organization address address: VIA BALBI 5 city: GENOVA postcode: 16126 website: www.unige.it contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	IT (GENOVA)	participant	1˙014˙560.00
3	THE CHANCELLOR MASTERS AND SCHOLARSOF THE UNIVERSITY OF CAMBRIDGE THE CHANCELLOR MASTERS AND SCHOLARSOF THE UNIVERSITY OF CAMBRIDGE Organization address address: TRINITY LANE THE OLD SCHOOLS city: CAMBRIDGE postcode: CB2 1TN website: www.cam.ac.uk contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	UK (CAMBRIDGE)	participant	778˙101.00
4	TECHNISCHE UNIVERSITAET MUENCHEN TECHNISCHE UNIVERSITAET MUENCHEN Organization address address: Arcisstrasse 21 city: MUENCHEN postcode: 80333 website: www.tu-muenchen.de contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	DE (MUENCHEN)	participant	599˙260.00
5	ITHERA MEDICAL GMBH ITHERA MEDICAL GMBH Organization address address: ZIELSTATTSTRASSE 13 city: MUNCHEN postcode: 81379 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	DE (MUNCHEN)	participant	535˙625.00
6	FUNDACIO INSTITUT DE CIENCIES FOTONIQUES FUNDACIO INSTITUT DE CIENCIES FOTONIQUES Organization address address: AVINGUDA CARL FRIEDRICH GAUSS 3 city: Castelldefels postcode: 8860 website: www.icfo.eu contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	ES (Castelldefels)	participant	506˙840.00
7	ITHERA SCIENTIFIC GMBH ITHERA SCIENTIFIC GMBH Organization address address: ZIELSTATTSTRASSE 13 city: MUNCHEN postcode: 81379 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	DE (MUNCHEN)	participant	260˙000.00
8	PINTAIL LTD PINTAIL LTD Organization address address: SPRINGHILL AVENUE 77 city: Blackrock postcode: A94 K542 website: www.pintail.eu contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	IE (Blackrock)	participant	250˙000.00
9	BIORIGEN SRL BIORIGEN SRL Organization address address: VIA DE MARINI 1 7TH FLOOR city: GENOVA postcode: 16149 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	IT (GENOVA)	participant	0.00

Map

Project objective

STARSTEM proposes imaging of stem cell engraftment in arthritic joints of large animals at clinically relevant depths, using nanoparticles with novel optical properties which enable unprecedented penetration depth and sensitivity. Arthritis is the most prevalent disease worldwide, with osteoarthritis (OA) affecting around 10% of the global population and around 70 million patients in Europe. There is no effective cure for OA at present and the majority of the treatments are symptomatic and not restorative. Stem cell therapy provides a unique opportunity for the self-regeneration of injured cartilage. One of the major hurdles in stem cell mediated-therapy is the inability to diagnose successful engraftment in real time using conventional imaging techniques. STARSTEM will address the major technology gaps to enable imaging of human stem cells at clinically relevant depths. STARSTEM is proposing the use of novel dual plasmonic gold nanostars (nanostars)-enhanced multi-modal imaging to detect stem cell engraftment and tissue repair, and thus their activity and efficacy as a therapy. STARSTEM will harness the best properties of light and sound with a photoacoustic (PA) imaging system for large animal and human finger imaging as proof-of-concept which exploits the unique advantages of our nanomaterial for differential and deep-tissue imaging. Functional imaging using PA enables the real time monitoring of engraftment and the therapeutic process at the site of interest, while highly sensitive anatomical imaging using MRI (using nanostar conjugated with magnetic nanoparticles as contrast agent) enables tracking of the movement and retention in individual organs of the transplanted cells that did not engraft. Algorithms for co-registered PA-MRI imaging approach will enable monitoring of the therapeutic process with high sensitivity. The overall imaging approach is designed to address small to large animal testing for efficacy and safety prior to clinical testing on humans.

Deliverables

List of deliverables.
Dissemination materials	Websites, patent fillings, videos etc.	2020-01-16 16:31:56
Website	Websites, patent fillings, videos etc.	2020-01-16 16:31:56

Take a look to the deliverables list in detail: detailed list of STARSTEM deliverables.

Publications

List of publications.
year	authors and title	journal	last update
2019	Sergey Alexandrov, Paul M. McNamara, Nandan Das, Yi Zhou, Gillian Lynch, Josh Hogan, Martin Leahy Spatial frequency domain correlation mapping optical coherence tomography for nanoscale structural characterization published pages: 121105, ISSN: 0003-6951, DOI: 10.1063/1.5110459	Applied Physics Letters 115/12	2020-01-16

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The information about "STARSTEM" are provided by the European Opendata Portal: CORDIS opendata.

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