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STARSTEM SIGNED

NanoSTARS imaging for STEM cell therapy for arthritic joints

Total Cost €

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EC-Contrib. €

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Partnership

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 STARSTEM project word cloud

Explore the words cloud of the STARSTEM project. It provides you a very rough idea of what is the project "STARSTEM" about.

cure    optical    advantages    differential    proposing    proposes    small    monitoring    10    photoacoustic    inability    majority    gold    safety    provides    unprecedented    worldwide    depths    nanostar    arthritic    did    animals    osteoarthritis    cells    sound    regeneration    movement    anatomical    mediated    deep    proof    hurdles    designed    engraftment    techniques    finger    diagnose    gaps    conventional    clinically    patients    nanomaterial    enhanced    therapy    sensitivity    oa    light    engraft    successful    nanoparticles    prevalent    tracking    opportunity    tissue    animal    pa    sensitive    stem    repair    global    mri    agent    self    cell    dual    organs    contrast    algorithms    transplanted    functional    starstem    humans    prior    registered    magnetic    efficacy    harness    symptomatic    exploits    site    time    population    therapeutic    co    disease    cartilage    imaging    modal    joints    plasmonic    conjugated    clinical    individual    retention    treatments    arthritis    human    detect    injured    nanostars    penetration    million    restorative   

Project "STARSTEM" data sheet

The following table provides information about the project.

Coordinator
NATIONAL UNIVERSITY OF IRELAND GALWAY 

Organization address
address: UNIVERSITY ROAD
city: Galway
postcode: H91
website: www.nuigalway.ie

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Ireland [IE]
 Project website http://starstem.eu/
 Total cost 5˙933˙952 €
 EC max contribution 5˙933˙952 € (100%)
 Programme 1. H2020-EU.2.1.2. (INDUSTRIAL LEADERSHIP - Leadership in enabling and industrial technologies – Nanotechnologies)
 Code Call H2020-NMBP-2017-two-stage
 Funding Scheme RIA
 Starting year 2018
 Duration (year-month-day) from 2018-01-01   to  2021-12-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    NATIONAL UNIVERSITY OF IRELAND GALWAY IE (Galway) coordinator 1˙989˙565.00
2    UNIVERSITA DEGLI STUDI DI GENOVA IT (GENOVA) participant 1˙014˙560.00
3    THE CHANCELLOR MASTERS AND SCHOLARSOF THE UNIVERSITY OF CAMBRIDGE UK (CAMBRIDGE) participant 778˙101.00
4    TECHNISCHE UNIVERSITAET MUENCHEN DE (MUENCHEN) participant 599˙260.00
5    ITHERA MEDICAL GMBH DE (MUNCHEN) participant 535˙625.00
6    FUNDACIO INSTITUT DE CIENCIES FOTONIQUES ES (Castelldefels) participant 506˙840.00
7    ITHERA SCIENTIFIC GMBH DE (MUNCHEN) participant 260˙000.00
8    PINTAIL LTD IE (Blackrock) participant 250˙000.00
9    BIORIGEN SRL IT (GENOVA) participant 0.00

Map

 Project objective

STARSTEM proposes imaging of stem cell engraftment in arthritic joints of large animals at clinically relevant depths, using nanoparticles with novel optical properties which enable unprecedented penetration depth and sensitivity. Arthritis is the most prevalent disease worldwide, with osteoarthritis (OA) affecting around 10% of the global population and around 70 million patients in Europe. There is no effective cure for OA at present and the majority of the treatments are symptomatic and not restorative. Stem cell therapy provides a unique opportunity for the self-regeneration of injured cartilage. One of the major hurdles in stem cell mediated-therapy is the inability to diagnose successful engraftment in real time using conventional imaging techniques. STARSTEM will address the major technology gaps to enable imaging of human stem cells at clinically relevant depths. STARSTEM is proposing the use of novel dual plasmonic gold nanostars (nanostars)-enhanced multi-modal imaging to detect stem cell engraftment and tissue repair, and thus their activity and efficacy as a therapy. STARSTEM will harness the best properties of light and sound with a photoacoustic (PA) imaging system for large animal and human finger imaging as proof-of-concept which exploits the unique advantages of our nanomaterial for differential and deep-tissue imaging. Functional imaging using PA enables the real time monitoring of engraftment and the therapeutic process at the site of interest, while highly sensitive anatomical imaging using MRI (using nanostar conjugated with magnetic nanoparticles as contrast agent) enables tracking of the movement and retention in individual organs of the transplanted cells that did not engraft. Algorithms for co-registered PA-MRI imaging approach will enable monitoring of the therapeutic process with high sensitivity. The overall imaging approach is designed to address small to large animal testing for efficacy and safety prior to clinical testing on humans.

 Deliverables

List of deliverables.
Dissemination materials Websites, patent fillings, videos etc. 2020-01-16 16:31:56
Website Websites, patent fillings, videos etc. 2020-01-16 16:31:56

Take a look to the deliverables list in detail:  detailed list of STARSTEM deliverables.

 Publications

year authors and title journal last update
List of publications.
2019 Sergey Alexandrov, Paul M. McNamara, Nandan Das, Yi Zhou, Gillian Lynch, Josh Hogan, Martin Leahy
Spatial frequency domain correlation mapping optical coherence tomography for nanoscale structural characterization
published pages: 121105, ISSN: 0003-6951, DOI: 10.1063/1.5110459
Applied Physics Letters 115/12 2020-01-16

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The information about "STARSTEM" are provided by the European Opendata Portal: CORDIS opendata.

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STARSTEM (2018)

NanoSTARS imaging for STEM cell therapy for arthritic joints

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