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ErasingFear SIGNED

Understanding the Stability and Plasticity of Emotional Memory

Total Cost €

EC-Contrib. €

Partnership

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ErasingFear project word cloud

Explore the words cloud of the ErasingFear project. It provides you a very rough idea of what is the project "ErasingFear" about.

breakthrough intervention expressions memory interventions fundamental wp4 mechanistic disorders gradual levels animal paradoxical framework translational procedure demarcate wp1 view science model fear preclude decline read behavioural resolved revolutionary gain affective interdependence paradigm bidirectional cognitive pharmacologically modification understand neural ways neuroscience theory suggest contrast discovery emotional abrupt memories wp3 clinical dominant drastically post insights changed dissociation questions consequently expression wp2 sleep inspired shift retrieval erase treatment underlying malleability delayed first wp5 serve neutralization thorough balance stability dynamic outs reconsolidation humans backwards

Project "ErasingFear" data sheet

The following table provides information about the project.

Coordinator	UNIVERSITEIT VAN AMSTERDAM Organization address address: SPUI 21 city: AMSTERDAM postcode: 1012WX website: www.uva.nl contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.
Coordinator Country	Netherlands [NL]
Total cost	2˙498˙328 €
EC max contribution	2˙498˙328 € (100%)
Programme	1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
Code Call	ERC-2016-ADG
Funding Scheme	ERC-ADG
Starting year	2018
Duration (year-month-day)	from 2018-01-01 to 2022-12-31

Partnership

Take a look of project's partnership.

#	participants	country	role	EC contrib. [€]
1	UNIVERSITEIT VAN AMSTERDAM UNIVERSITEIT VAN AMSTERDAM Organization address address: SPUI 21 city: AMSTERDAM postcode: 1012WX website: www.uva.nl contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	NL (AMSTERDAM)	coordinator	2˙498˙328.00

Map

Project objective

The breakthrough discovery in animal research that fear memories may change upon retrieval – referred to as memory reconsolidation – has drastically changed the view on the malleability of emotional memory. Inspired by these insights, we have developed a novel approach to pharmacologically erase the affective component from fear memories in humans. Although these findings suggest a paradigm shift in clinical practice, there are many fundamental questions to be resolved.

The objective of this proposal is to gain an in-depth, comprehensive understanding of the dynamic balance between the stability and malleability of emotional memory, and consequently develop a revolutionary theory-driven treatment for emotional memory disorders.

This program presents a novel mechanistic framework on memory reconsolidation challenging in several ways the dominant model of emotional memory modification. First, while during traditional interventions cognitive changes are required for a reduction in fear, in our procedure cognitive changes preclude the neutralization of fear memory. On the other hand, post-retrieval changes in the cognitive (WP1) and neural (WP2) expression of fear memory may serve as read-outs to demarcate the underlying processes necessary for memory reconsolidation. Second, in contrast to the immediate, but gradual decline of fear during traditional interventions, with memory reconsolidation the fear reduction is delayed, yet abrupt, and sleep may be essential (WP3). A thorough understanding of these processes is essential for developing a reconsolidation intervention in clinical practice (WP4). Finally, the program aims to understand the paradoxical dissociation, yet interdependence, between the cognitive and emotional expressions of fear memory (WP5). This proposal is unique in its bidirectional translational approach. It involves different levels of analysis: from behavioural science, to neuroscience to clinical science, and backwards.

Publications

List of publications.
year	authors and title	journal	last update
2018	Merel Kindt The surprising subtleties of changing fear memory: a challenge for translational science published pages: 20170033, ISSN: 0962-8436, DOI: 10.1098/rstb.2017.0033	Philosophical Transactions of the Royal Society B: Biological Sciences 373/1742	2019-09-26
2018	James Elsey, Merel Kindt Can criminals use propranolol to erase crime-related memories? A response to McGorrery (2017) published pages: 136-138, ISSN: 1037-969X, DOI: 10.1177/1037969x18765204	Alternative Law Journal 43/2	2019-09-26
2018	Leonidas Faliagkas, Priyanka Rao-Ruiz, Merel Kindt Emotional memory expression is misleading: delineating transitions between memory processes published pages: 116-122, ISSN: 2352-1546, DOI: 10.1016/j.cobeha.2017.12.018	Current Opinion in Behavioral Sciences 19	2019-09-26
2018	James W. B. Elsey, Vanessa A. Van Ast, Merel Kindt Human memory reconsolidation: A guiding framework and critical review of the evidence. published pages: 797-848, ISSN: 0033-2909, DOI: 10.1037/bul0000152	Psychological Bulletin 144/8	2019-09-09

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