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UPRECON SIGNED

Ultrafast photonics for the detection and recognition of toxic spine-structures of amyloid aggregates linked to neurodegenerative disease

Total Cost €

0

EC-Contrib. €

0

Partnership

0

Views

0

 UPRECON project word cloud

Explore the words cloud of the UPRECON project. It provides you a very rough idea of what is the project "UPRECON" about.

science    structural    oligomeric    inhibition    time    supplementary    host    health    doctoral    absorption    expertise    human    benefits    skills    enormous    cells    ultrafast    surgical    form    person    career    acute    safe    worsening    biophotonics    training    setups    polish    patients    tissues    society    chemical    region    detect    intensity    ancillary    diagnose    forms    brains    spectroscopy    academy    transfer    cognition    2050    laser    clear    proteins    building    symptoms    alzheimer    indicate    amyloid    toxic    suspected    damage    technique    regarding    methodology    potentially    fibril    reduces    post    strategy    designed    multiphoton    newly    diagnosis    diagnosed    intervention    85    me    peptides    fibrils    resolved    modality    projections    detection    diseases    combination    intermediates    curing    disease    labels    invasive    parkinson    infrared    laboratory    aged    pathogenic    aggregates    irradiation    architectures    light    persons   

Project "UPRECON" data sheet

The following table provides information about the project.

Coordinator
UNIWERSYTET WARSZAWSKI 

Organization address
address: KRAKOWSKIE PRZEDMIESCIE 26/28
city: WARSZAWA
postcode: 00 927
website: www.uw.edu.pl

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Poland [PL]
 Total cost 134˙462 €
 EC max contribution 134˙462 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2016
 Funding Scheme MSCA-IF-EF-RI
 Starting year 2018
 Duration (year-month-day) from 2018-08-01   to  2020-07-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNIWERSYTET WARSZAWSKI PL (WARSZAWA) coordinator 134˙462.00
2    INSTYTUT CHEMII FIZYCZNEJ POLSKIEJ AKADEMII NAUK PL (WARSZAWA) participant 0.00

Map

 Project objective

Projections indicate that, by 2050, every person aged 85 years or more will be diagnosed with a cognition-related disease. While there is currently no clear strategy for curing such diseases, there are promising developments in the early diagnosis of disease and the inhibition of worsening symptoms. Building on results obtained during my post-doctoral work regarding laser technology for amyloid aggregates detection, I propose to use an advanced ultrafast spectroscopy for structural analyses of the peptides and proteins that form the different fibril architectures in the brains of patients with pathogenic aggregates. In combination with multiphoton absorption, this laser technique has the potential to detect and diagnose in a non-invasive modality the early forms of toxic oligomeric intermediates in the brains of persons with suspected Alzheimer´s or Parkinson´s disease. This methodology has potentially enormous benefits for patients and society. Importantly, the proposed approach of using high-intensity light in the infrared region of absorption does not damage cells and tissues during long-duration irradiation, it does not require the use of chemical labels, and it reduces the need for surgical intervention, as it is non-invasive and safe for human health. I will transfer the knowledge and expertise on biophotonics of amyloid fibrils to Europe and the Host laboratory at the Polish Academy of Science will provide me with advanced training in time-resolved ultrafast laser spectroscopy and access to newly designed setups, as well as supplementary career path-specific training in ancillary skills.

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The information about "UPRECON" are provided by the European Opendata Portal: CORDIS opendata.

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