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MHINT SIGNED

Genetic, behavioural and cognitive mechanisms underpinning the association between mother and offspring mental health problems: mental (M) health (H) intergenerational transmission (INT) -(MHINT)

Total Cost €

EC-Contrib. €

Partnership

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Outcomes and
results

MHINT project word cloud

Explore the words cloud of the MHINT project. It provides you a very rough idea of what is the project "MHINT" about.

gt respective intergenerational associations children mentally international data cameras mechanisms life critical wearable dyads explaining break n 300 synthesis first decades prevention generations valid measured nature is intervention mothers child modifying harness cohort generation sensitive mental recording highlighted cognitive underpinnings g2 cohorts ill alspac time despite introduction transmission computational maternal health ecologically transmitted genetically interventions reinforcing eye chiefly tracking systematic passed shed uniquely interaction models environmental manifestation components mother infant themselves designs regarding hypotheses extract home behavioural genetic substantially alternative trials risk parenting review modification light cycle reduce phenotypic modeling

Project "MHINT" data sheet

The following table provides information about the project.

Coordinator	UNIVERSITY OF BRISTOL Organization address address: BEACON HOUSE QUEENS ROAD city: BRISTOL postcode: BS8 1QU website: www.bristol.ac.uk contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.
Coordinator Country	United Kingdom [UK]
Project website	https://www.researchgate.net/project/Mental-Health-Intergenerational-Transmission-MHINT
Total cost	1˙499˙611 €
EC max contribution	1˙499˙611 € (100%)
Programme	1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
Code Call	ERC-2017-STG
Funding Scheme	ERC-STG
Starting year	2017
Duration (year-month-day)	from 2017-12-01 to 2022-11-30

Partnership

Take a look of project's partnership.

#	participants	country	role	EC contrib. [€]
1	UNIVERSITY OF BRISTOL UNIVERSITY OF BRISTOL Organization address address: BEACON HOUSE QUEENS ROAD city: BRISTOL postcode: BS8 1QU website: www.bristol.ac.uk contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	UK (BRISTOL)	coordinator	1˙499˙611.00

Map

Project objective

Despite decades of research, and the introduction of parenting interventions, children of mentally ill mothers remain substantially more likely to have mental health problems themselves. I propose to shed new light on why mental health problems in a mother are passed on to her child, and help break this reinforcing cycle of mental health risk across generations. In order to harness the potential of modifying parenting for the prevention of child mental health risk, I will study parenting using more detailed, ecologically valid and genetically sensitive designs than have been done before. Objectives: 1: To investigate the respective role of genetic and environmental (chiefly parenting) mechanisms in explaining associations between mother and child mental health. HOW: using a consortium of international cohorts with intergenerational genetic and phenotypic data (n>10,000) and, for the first time, modeling genetic risk which is and is not transmitted from mother to child to test alternative hypotheses. 2: To identify behavioural manifestation of maternal mental health, in observed mother-infant interaction, in an ecologically valid way. HOW: recording 300 mother- child dyads at home, using novel wearable cameras, in the next generation of a key cohort (ALSPAC-G2). 3: To identify cognitive underpinnings of maternal behaviour. HOW: including cognitive tasks (with eye tracking) as new measures in ALSPAC-G2, applying computational models to cognitive and (uniquely) real life data (measured in 2). 4: To establish whether modification of maternal parenting (highlighted in 1-3), changes child mental health. HOW: systematic review of parenting intervention trials and new synthesis methods to extract which intervention components reduce child mental health problems. My study will provide critical new evidence regarding the nature of parenting interventions that have potential to improve child mental health and break intergenerational transmission of mental health problems.

Publications

List of publications.
year	authors and title	journal	last update
2018	Rebecca M. Pearson, Rebecca E. Carnegie, Callum Cree, Claire Rollings, Louise Rena-Jones, Jonathan Evans, Alan Stein, Kate Tilling, Melanie Lewcock, Debbie A. Lawlor Prevalence of Prenatal Depression Symptoms Among 2 Generations of Pregnant Mothers published pages: e180725, ISSN: 2574-3805, DOI: 10.1001/jamanetworkopen.2018.0725	JAMA Network Open 1/3	2019-08-30

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The information about "MHINT" are provided by the European Opendata Portal: CORDIS opendata.