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ToMeTuM SIGNED

Towards the Understanding a Metal-Tumour-Metabolism

Total Cost €

EC-Contrib. €

Partnership

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ToMeTuM project word cloud

Explore the words cloud of the ToMeTuM project. It provides you a very rough idea of what is the project "ToMeTuM" about.

containing genetic lethal modifications 4t1 experimental carboplatin melanomas platinum vivo occurrence cisplatin direct correlations vitro discovered melim mcf drug found explaining models unclear relationships optimize metal weapons discovery uses sought minipigs biological proteins tested interactions effectiveness mice proved molecularly genes anticancer ion carcinogenetic metals resistance revealing metallothioneins biochemical ions window grow immune treatments cell spectrometric description actions strategies protect monitored oxaliplatin itself mechanisms suppress electrochemical cancer coping precise gaining animal data reveal mass purpose markedly tumours metabolism copes protein exact breast mechanism tumour treatment drugs metallothionein bearing

Project "ToMeTuM" data sheet

The following table provides information about the project.

Coordinator	VYSOKE UCENI TECHNICKE V BRNE Organization address address: ANTONINSKA 548/1 city: BRNO STRED postcode: 601 90 website: www.vutbr.cz contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.
Coordinator Country	Czech Republic [CZ]
Total cost	1˙377˙495 €
EC max contribution	1˙377˙495 € (100%)
Programme	1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
Code Call	ERC-2017-STG
Funding Scheme	ERC-STG
Starting year	2018
Duration (year-month-day)	from 2018-01-01 to 2022-12-31

Partnership

Take a look of project's partnership.

#	participants	country	role	EC contrib. [€]
1	VYSOKE UCENI TECHNICKE V BRNE VYSOKE UCENI TECHNICKE V BRNE Organization address address: ANTONINSKA 548/1 city: BRNO STRED postcode: 601 90 website: www.vutbr.cz contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	CZ (BRNO STRED)	coordinator	1˙377˙495.00

Map

Project objective

A tumour cell uses both genetic and protein weapons in its development. Gaining a greater understanding of these lethal mechanisms is a key step towards developing novel and more effective treatments. Because the metal ion metabolism of a tumour cell is not fully understood, we will address the challenge of explaining the mechanisms of how a tumour cell copes both with essential metal ions and platinum based drugs. The metal-based mechanisms help a tumour to grow on one side and to protect itself against commonly used metal-based drugs. On the other side, the exact description of these mechanisms, which are being associated with multi-drug resistance occurrence and failure of a treatment, still remains unclear. We will reveal the mechanism of the as yet not understood biochemical and molecularly-biological relationships and correlations between metal ions and proteins in a tumour development revealing the way how to suppress the growth and development of a tumour and to markedly enhance the effectiveness of a treatment.

To achieve this goal, we will focus on metallothionein and its interactions with essential metals and metal-containing anticancer drugs (cisplatin, carboplatin, and oxaliplatin). Their actions will be monitored both in vitro and in vivo. For this purpose, we will optimize electrochemical, mass spectrometric and immune-based methods. Based on processing of data obtained, new carcinogenetic pathways will be sought on cell level and proved by genetic modifications of target genes. The discovered processes and the pathways found will then be tested on two animal experimental models mice bearing breast tumours (MCF-7 and 4T1) and MeLiM minipigs bearing melanomas.

The precise description of the tumour related pathways coping with metal ions based on metallothioneins will direct new highly effective treatment strategies. Moreover, the discovery of new carcinogenetic pathways will open a window for understanding of cancer formation and development.

Publications

List of publications.
year	authors and title	journal	last update
2019	Yazan Haddad, Vojtech Adam, Zbynek Heger Rotamer Dynamics: Analysis of Rotamers in Molecular Dynamics Simulations of Proteins published pages: 2062-2072, ISSN: 0006-3495, DOI: 10.1016/j.bpj.2019.04.017	Biophysical Journal 116/11	2019-09-02
2019	Miguel Rodrigo, Hana Buchtelova, Ana Jimenez, Pavlina Adam, Petr Babula, Zbynek Heger, Vojtech Adam Transcriptomic Landscape of Cisplatin-Resistant Neuroblastoma Cells published pages: 235, ISSN: 2073-4409, DOI: 10.3390/cells8030235	Cells 8/3	2019-09-02
2019	Tereza Vaneckova, Lucie Vanickova, Michaela Tvrdonova, Adam Pomorski, Artur KrÄ™Å¼el, Tomas Vaculovic, Viktor Kanicky, Marketa Vaculovicova, Vojtech Adam Molecularly imprinted polymers coupled to mass spectrometric detection for metallothionein sensing published pages: 224-229, ISSN: 0039-9140, DOI: 10.1016/j.talanta.2019.01.089	Talanta 198	2019-09-02
2019	Lucie Vanickova, Roman Guran, SÃ¡ndor KollÃ¡r, Gabriella Emri, Sona Krizkova, Tomas Do, Zbynek Heger, Ondrej Zitka, Vojtech Adam Mass spectrometric imaging of cysteine rich proteins in human skin published pages: 270-277, ISSN: 0141-8130, DOI: 10.1016/j.ijbiomac.2018.11.272	International Journal of Biological Macromolecules 125	2019-09-02
2019	Miguel Angel Merlos Rodrigo, Hana Buchtelova, Vivian de los Rios, JosÃ© Ignacio Casal, Tomas Eckschlager, Jan Hrabeta, Marie Belhajova, Zbynek Heger, Vojtech Adam Proteomic Signature of Neuroblastoma Cells UKF-NB-4 Reveals Key Role of Lysosomal Sequestration and the Proteasome Complex in Acquiring Chemoresistance to Cisplatin published pages: 1255-1263, ISSN: 1535-3893, DOI: 10.1021/acs.jproteome.8b00867	Journal of Proteome Research 18/3	2019-08-05

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The information about "TOMETUM" are provided by the European Opendata Portal: CORDIS opendata.