YinYang SIGNED
Hypothalamic circuits for the selection of defensive and mating behavior in females
Total Cost €
0EC-Contrib. €
0Partnership
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Project "YinYang" data sheet
The following table provides information about the project.
| Coordinator |
FUNDACAO D. ANNA SOMMER CHAMPALIMAUD E DR. CARLOS MONTEZ CHAMPALIMAUD
Organization address contact info |
| Coordinator Country | Portugal [PT] |
| Total cost | 1˙952˙188 € |
| EC max contribution | 1˙952˙188 € (100%) |
| Programme |
1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC)) |
| Code Call | ERC-2017-COG |
| Funding Scheme | ERC-COG |
| Starting year | 2018 |
| Duration (year-month-day) | from 2018-03-01 to 2023-02-28 |
Partnership
Take a look of project's partnership.
| # | ||||
|---|---|---|---|---|
| 1 | FUNDACAO D. ANNA SOMMER CHAMPALIMAUD E DR. CARLOS MONTEZ CHAMPALIMAUD | PT (LISBOA) | coordinator | 1˙952˙188.00 |
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Project objective
Social interactions can take different courses depending on the internal state of the participants. For instance, a sexually receptive female mouse will allow a male’s attempt to mount her, but a non-receptive female will fight or flee the same male. Here, we propose to determine how neuronal circuits in the female mouse brain support flexible, state-dependent interactions with male conspecifics. It is known that female receptivity depends on the ventrolateral region of the ventromedial hypothalamus. Within this region there is a population of neurons that expresses receptors for the sex hormone progesterone (PR neurons), whose levels cycle with reproductive state. In pilot experiments, we found that PR neurons are not homogeneous: some respond during receptive behaviors but others respond during defensive or aggressive behaviors. Our main objective is to determine how female hypothalamic PR neurons participate in state-dependent behavioral responses to males. Our hypothesis is that two subpopulations of PR neurons are differentially modulated by the reproductive cycle and that each sub-population activates a different downstream circuit, one specialized for receptive and the other for defensive behaviors. Our specific aims are to: (1) characterize the functional selectivity of individual female PR neurons across the reproductive cycle; (2) map the connectivity of PR neurons to their output targets; (3) test the impact of different PR output pathways by genetically activating and silencing them; and (4) determine how reproductive hormones modulate the synaptic and intrinsic functional properties of PR neurons. These studies will elucidate the neuronal circuit mechanisms of a biologically essential female behavior. More broadly, this work will reveal mechanisms by which neuronal circuits can support flexible state-dependent adaptive behaviors.
Publications
| year | authors and title | journal | last update |
|---|---|---|---|
| 2019 |
Francisco F. Esteves, Diogo Matias, Ana R. Mendes, Bertrand Lacoste, Susana Q. Lima Sexually dimorphic neuronal inputs to the neuroendocrine dopaminergic system governing prolactin release published pages: , ISSN: 0953-8194, DOI: 10.1111/jne.12781 |
Journal of Neuroendocrinology 31/10 | 2020-01-30 |
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