#	Pagina
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InvADeRS SIGNED

Investigating the Activity of transposon Derived Regulatory Sequences in the placenta

Total Cost €

EC-Contrib. €

Partnership

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InvADeRS project word cloud

Explore the words cloud of the InvADeRS project. It provides you a very rough idea of what is the project "InvADeRS" about.

landscape regulation deep placental trophoblast highlighting tissue mouse complications explored co aberrant host motif gene te programs measuring coding map expression functional opted network restriction candidates disease transposable tes reveal implicated signatures unexplained transcription dna permissive ex crispr normal editing transcriptomic diseases sequences invasion histone species vitro regulate cis homeostasis elucidate notably cas9 placenta characterised driving function candidate human unexplored vivo recurrent placentas potentially genes preeclampsia modification humans interstitial loci enhancers correlations binding sites epigenetic differences genome fetal complicated causes apes pregnancy regulatory

Project "InvADeRS" data sheet

The following table provides information about the project.

Coordinator	QUEEN MARY UNIVERSITY OF LONDON Organization address address: 327 MILE END ROAD city: LONDON postcode: E1 4NS website: http://www.qmul.ac.uk contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.
Coordinator Country	United Kingdom [UK]
Total cost	224˙933 €
EC max contribution	224˙933 € (100%)
Programme	1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
Code Call	H2020-MSCA-IF-2018
Funding Scheme	MSCA-IF-EF-RI
Starting year	2019
Duration (year-month-day)	from 2019-05-01 to 2021-04-30

Partnership

Take a look of project's partnership.

#	participants	country	role	EC contrib. [€]
1	QUEEN MARY UNIVERSITY OF LONDON QUEEN MARY UNIVERSITY OF LONDON Organization address address: 327 MILE END ROAD city: LONDON postcode: E1 4NS website: http://www.qmul.ac.uk contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	UK (LONDON)	coordinator	224˙933.00

Map

Project objective

Aberrant epigenetic regulation of placental function is implicated in several complications of pregnancy, such as preeclampsia, recurrent pregnancy loss and fetal growth restriction. Notably, the placenta has a unique epigenetic landscape, permissive for the activity of transposable element (TE) derived DNA sequences. TEs are often co-opted by the host genome as cis-regulatory elements, driving tissue- and species-specific gene expression programs. Indeed, TEs contribute many placental-specific enhancers in mouse trophoblast. However, the presence and role of a similar TE-derived regulatory network has not been explored in human trophoblast. As TEs are highly species-specific, such a network in humans would be expected to regulate species-specific placental characteristics, such as the deep interstitial invasion unique to great apes. TE-derived regulatory elements may therefore be important for placental homeostasis and be involved in diseases characterised by aberrant placental invasion. I propose to map TE-derived cis-regulatory sequences in human trophoblast ex vivo using their histone modification signatures. I will assess the regulatory potential of candidate TEs through transcriptomic analyses and motif analysis to reveal transcription factor binding sites, highlighting promising candidates of importance in the human placenta. I will then directly test the function of top TE candidates using CRISPR-Cas9 genome editing of the TEs in trophoblast in vitro, and measuring changes in expression of target genes. Finally, I will elucidate epigenetic and coding differences between complicated and normal control placentas at the functional regulatory TE loci I find, to identify correlations with disease. This project will provide a comprehensive analysis of an as-yet unexplored aspect of human placental epigenetic regulation, and potentially identify novel causes of common unexplained complications of human pregnancy.

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The information about "INVADERS" are provided by the European Opendata Portal: CORDIS opendata.