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BIONICS SIGNED

A biomimetic and neuroprotective delivery nanocapsule for the targeted treatment of post-ischemic stroke effects

Total Cost €

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EC-Contrib. €

0

Partnership

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 BIONICS project word cloud

Explore the words cloud of the BIONICS project. It provides you a very rough idea of what is the project "BIONICS" about.

acquire    stress    deficits    stroke    writing    nanoparticles    iit    molecular    presented    ceo2    techniques    lipid    antioxidant    me    found    grant    ros    damage    countries    occurs    overproduced    region    biomimetic    transfer    ischemic    biology    vessel    ing    million    goals    unfortunately    inhibitors    amelioration    limited    showed    thought    pathogenesis    inos    workshops    researcher    market    expertise    seminars    blood    closer    plans    impending    opportunity    2034    action       believe    nanocapsule    total    safely    nil    oxidative    permanent    neurological    date    prevent    morbidity    rns    skills    transferable    mmp    bbb    gained    caused    percentages    microfluidic    give    incidents    independent    neuroprotective    anti    models    blockage    fabrication    43    63    synthesis    first    perfusion    treatment    bionics    reducing    mortality    therapeutic    overproduction    nanocapsules    post    worldwide    brain    oxidant    death    career    treatments   

Project "BIONICS" data sheet

The following table provides information about the project.

Coordinator
FONDAZIONE ISTITUTO ITALIANO DI TECNOLOGIA 

Organization address
address: VIA MOREGO 30
city: GENOVA
postcode: 16163
website: www.iit.it

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Italy [IT]
 Total cost 168˙277 €
 EC max contribution 168˙277 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2017
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2018
 Duration (year-month-day) from 2018-05-01   to  2020-04-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    FONDAZIONE ISTITUTO ITALIANO DI TECNOLOGIA IT (GENOVA) coordinator 168˙277.00

Map

 Project objective

Ischemic stroke occurs due to reduced perfusion to a brain region, because of the blockage of a blood vessel, resulting in death or permanent neurological deficits. It presents high percentages of mortality and morbidity worldwide and market analysis in five major EU countries showed that the total number of first-ever incidents of stroke cases will rise to 1.63 million (43.7% growth) by 2034. Although, many treatments that make use of therapeutic nanoparticles have been presented, unfortunately to date, no effective treatment has been found to prevent damage to the ischemic brain after stroke. Oxidative stress is related to the pathogenesis of stroke and overproduction of ROS and RNS are thought to be the main cause of this. In addition, the overproduction of MMP-9 has been related to many post-stroke side effects. Thus, I propose the development of a biomimetic and neuroprotective lipid nanocapsule (BIONICS) for the targeted treatment of post-stroke side effects. BIONICS will safely deliver anti-oxidant nanoparticles (CeO2) and iNOS inhibitors (L-NIL) across the BBB aiming at reducing the overproduced ROS, RNS and MMP-9, resulting in to the amelioration of the neurological deficits caused by oxidative stress. Through this project, the new skills in the synthesis of antioxidant nanocapsules, the use of molecular biology techniques, design and fabrication of microfluidic models, project management, grant writing, and other transferable skills that I will acquire in IIT, will help my future career plans providing knowledge and expertise in a field where my knowledge is limited. This action will also give me the opportunity to transfer my pre-gained knowledge through seminars/workshops to the institution where my research will be carried out. Overall, I believe that BIONICS will have a significant impact on my short and long-term career goals and will bring me one step closer to my impending goal of the independent researcher.

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The information about "BIONICS" are provided by the European Opendata Portal: CORDIS opendata.

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