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NaTOS SIGNED

Nanoscale Thermo Optical Sensing

Total Cost €

EC-Contrib. €

Partnership

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NaTOS project word cloud

Explore the words cloud of the NaTOS project. It provides you a very rough idea of what is the project "NaTOS" about.

probe nor monitoring thermo plasmonic respect interactions laser induces gold source suffer provides labels obtain rely restrictions nanoscale time interaction nrs analytes possibility receptors bio nanorods intensity optical sensing techniques requirement tethering multiplexing consequent natos tunable analyte nr statistical binding simultaneous thermophortic thermophoretic life behavior monitor fluorescent contrast heating proteins free truly datasets extend nearfield utilizes fingerprints near molecular diffuse label scattered device gradient species temperature transient nanorod distinguish sensor monitored enzymes single

Project "NaTOS" data sheet

The following table provides information about the project.

Coordinator	UNIVERSITEIT LEIDEN Organization address address: RAPENBURG 70 city: LEIDEN postcode: 2311 EZ website: www.universiteitleiden.nl contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.
Coordinator Country	Netherlands [NL]
Total cost	165˙598 €
EC max contribution	165˙598 € (100%)
Programme	1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
Code Call	H2020-MSCA-IF-2017
Funding Scheme	MSCA-IF-EF-ST
Starting year	2018
Duration (year-month-day)	from 2018-03-01 to 2020-02-29

Partnership

Take a look of project's partnership.

#	participants	country	role	EC contrib. [€]
1	UNIVERSITEIT LEIDEN UNIVERSITEIT LEIDEN Organization address address: RAPENBURG 70 city: LEIDEN postcode: 2311 EZ website: www.universiteitleiden.nl contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	NL (LEIDEN)	coordinator	165˙598.00

Map

Project objective

NaTOS: Nanoscale Thermo Optical Sensing is the concept of a new truly label free bio-sensor device capable of monitoring transient molecular interactions. The sensor utilizes plasmonic gold nanorods (NR) as both nanoscale heating source and optical near field sensor. Proteins and enzymes will be monitored as they change the intensity scattered by a single NR as they diffuse through the nanorod's nearfield. The simultaneous laser induced and thus tunable heating of the NR will induces a nanoscale temperature gradient that allows to probe the analytes with respect to their thermophoretic behavior. This analyte specific behavior provides specific thermophortic fingerprints which will be used to identify and distinguish between different proteins and in further extend also to monitor the interaction between different species of analytes. This novel type of sensor does not require fluorescent labels nor does it rely on tethering of specific receptors and the consequent binding of analytes to the NRs. In contrast to current state of the art techniques this truly label-free sensor does not suffer from binding induced life time restrictions and can obtain statistical significant datasets without the requirement, but with the possibility of multiplexing.

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The information about "NATOS" are provided by the European Opendata Portal: CORDIS opendata.