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sigNal SIGNED

Novel insights into the sensing of salt stress in plants: understanding the relationship between salt stress response and cytosolic pH changes.

Total Cost €

EC-Contrib. €

Partnership

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sigNal project word cloud

Explore the words cloud of the sigNal project. It provides you a very rough idea of what is the project "sigNal" about.

activates alkalinisation regulatory interactions ser demonstrated relaying cells homeostasis salt posit visualisation stresses concentration experiments shoots signature ph structural recruits cytosolic responsible regulates localized technics induce antiporter plant levels dependent localisations sensing sensor messenger postdoct criteria calcium sensed toxic signal stage mechanisms stress input sodicity na pm variety accumulation signalling duiring learned triggered prof experimental thr determinants salinity sos1 protein activate provokes abiotic fluorescence components overly subcellular alkaline integrate plants schumacher sos3 sos ca existence group paradigm signals meet kinase shift prevents intracellular free sos2 roots phosphorylation partition ratio additional core sensitive imaging perceives hypothesis activated initiate

Project "sigNal" data sheet

The following table provides information about the project.

Coordinator	RUPRECHT-KARLS-UNIVERSITAET HEIDELBERG Organization address address: SEMINARSTRASSE 2 city: HEIDELBERG postcode: 69117 website: www.uni-heidelberg.de contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.
Coordinator Country	Germany [DE]
Total cost	171˙460 €
EC max contribution	171˙460 € (100%)
Programme	1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
Code Call	H2020-MSCA-IF-2017
Funding Scheme	MSCA-IF-EF-ST
Starting year	2018
Duration (year-month-day)	from 2018-09-01 to 2020-08-31

Partnership

Take a look of project's partnership.

#	participants	country	role	EC contrib. [€]
1	RUPRECHT-KARLS-UNIVERSITAET HEIDELBERG RUPRECHT-KARLS-UNIVERSITAET HEIDELBERG Organization address address: SEMINARSTRASSE 2 city: HEIDELBERG postcode: 69117 website: www.uni-heidelberg.de contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	DE (HEIDELBERG)	coordinator	171˙460.00

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Project objective

The Salt Overly Sensitive (SOS) pathway is one of the main regulatory systems responsible for Na homeostasis in plants. The SOS pathway is activated by salt stress and comprises three core components: SOS1, SOS2 and SOS3. SOS3 is a calcium (Ca) sensor that perceives the increase of intracellular Ca triggered by salt stress and recruits SOS2, a Ser/Thr protein kinase, to the PM. The complex activates protein SOS1 by phosphorylation, a PM-localized Na/H antiporter that prevents the accumulation of Na to toxic levels and regulates Na partition between roots and shoots. Cytosolic free Ca is a common second messenger in the signalling of a variety of abiotic stresses. The wide range of Ca-activated responses lead us to posit the existence of additional mechanisms relaying input signals that, together with this Ca signature, would initiate the specific response for a particular stress. The hypothesis of my proposal is that the increase in intracellular Na concentration provokes the alkalinisation of the intracellular pH, what would be sensed by SOS3. SOS3 would work as pH and Ca sensor, which would integrate this pH shift and the Ca signature to activate SOS pathway.

To support the hypothesis of cytosolic alkalinisation as a salt stress signal and SOS3 as a Ca and pH sensor, two experimental criteria must be meet: (1) salinity should induce an alkaline pH shift in plant cells, and (2) structural determinants of pH-sensing should be demonstrated in SOS3. To achieve my goal: (1) I will use a system, improved by Prof. Schumacher’s group, which allows the visualisation of pH changes in selected subcellular localisations through fluorescence ratio imaging experiments; and (2) I will use the technics learned and used duiring my postdoct stage to study whether SOS3 interactions and/or activity are pH dependent.

This research will provide a new paradigm of how sodicity is sensed by plant cells.

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The information about "SIGNAL" are provided by the European Opendata Portal: CORDIS opendata.