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NanoFEITH SIGNED

Nanoparticles for Fluorescence-Enhanced Imaging and Therapy of Breast Cancer

Total Cost €

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EC-Contrib. €

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Partnership

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 NanoFEITH project word cloud

Explore the words cloud of the NanoFEITH project. It provides you a very rough idea of what is the project "NanoFEITH" about.

complement    drug    theranostic    resistant    tips    tumours    offers    personalized    zn    combining    near    chemotherapeutic    fluorescence    systemic    therapeutic    active    gold    paving    spatial    biocompatibility    surface    infrared    combine    coordinated    materials    site    first    bc    lids    therapy    coating    minimize    cultures    strategy    skills    nir    fluorescent    dramatically    resolution    bearing    nanomedicine    passive    3d    cancer    carrier    international    toward    promise    au    imaging    combined    photothermal    np    optical    death    collaborations    treating    host    sensitivity    platforms    expertise    science    insights    complementary    nanoparticles    limited    sizes    professional    time    vitro    biodistribution    efficacy    multimodal    modalities    multidisciplinary    mitigating    signals    clinical    training    nps    ph    techniques    core    sharp    cell    nanotechnology    enhancement    ion    accumulation    advantages    tunable    breast    enhanced    nanobipyramids    elongated    maturity    vs    metal    mef    worldwide    detection    computational    ineffective    mortality    dyes    translation    responsive    tumour    vivo    vital    diagnosis    release    treatment    women   

Project "NanoFEITH" data sheet

The following table provides information about the project.

Coordinator
UNIVERSITY OF CYPRUS 

Organization address
address: KALLIPOLEOS STREET 75
city: NICOSIA
postcode: 1678
website: www.ucy.ac.cy

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Cyprus [CY]
 Total cost 151˙648 €
 EC max contribution 151˙648 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2017
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2018
 Duration (year-month-day) from 2018-06-01   to  2020-05-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNIVERSITY OF CYPRUS CY (NICOSIA) coordinator 151˙648.00

Map

 Project objective

Breast cancer (BC) represents a leading cause of cancer-related death in women worldwide, in large part due to ineffective detection and treatment. Nanotechnology offers new promise in mitigating BC mortality, by combining therapy with early diagnosis in “theranostic” nanoparticles (NPs). Here, a multidisciplinary approach is proposed to develop and evaluate novel theranostic NPs, which for the first time combine near infrared (NIR) metal-enhanced fluorescence (MEF) imaging with multimodal cancer treatment. MEF is a promising strategy for dramatically improving the low fluorescent signals of available NIR dyes, but limited MEF platforms for in vivo applications have been developed. Here, elongated gold (Au) NPs (nanobipyramids) with two sharp tips and tunable sizes/optical properties are expected to provide distinct advantages, including large fluorescence enhancement and increased tumour accumulation, thus enabling real-time in vivo imaging with high sensitivity and spatial resolution. Furthermore, BC photothermal therapy by the Au core will be combined with a chemotherapeutic drug-carrier surface coating, bearing pH-responsive lids to allow controlled drug and Zn ion release at the tumour site. Coordinated use of these modalities is expected to minimize systemic side effects, improve therapeutic efficacy and be useful in treating drug resistant tumours. Several complementary techniques, including computational modelling, 3D in vitro cell cultures, in vivo testing and advanced 3D imaging will be combined to characterize NP biodistribution, biocompatibility and passive vs. active tumour targeting. These will provide vital insights for the – still challenging – clinical translation of NPs in general, paving the way toward personalized nanomedicine. The proposed research/training will complement the Applicant’s skills in materials science with the Host’s expertise in cancer drug delivery to enhance his professional maturity and promote international collaborations.

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The information about "NANOFEITH" are provided by the European Opendata Portal: CORDIS opendata.

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