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NEVULA SIGNED

Understanding selective neuronal vulnerability in Alzheimer’s disease

Total Cost €

EC-Contrib. €

Partnership

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NEVULA project word cloud

Explore the words cloud of the NEVULA project. It provides you a very rough idea of what is the project "NEVULA" about.

p301s prof cortex modulate susceptibility intervention tangle understand ribosome genes stages immunofluorescence validated network rna netwas therapeutic disease add bound explore neuroscience followed acute patients underlying earlier transgenic association immunoprecipitation neurodegeneration seq alzheimer hybridization expression influence aav mechanisms mice extremely greengard nft ecii situ action braak perform bactrap mouse enthorinal lesions pathological ad lab modulation stereotaxic human mrnas samples injections appear neurons pathogenesis neurofibrillary profile reveal brain

Project "NEVULA" data sheet

The following table provides information about the project.

Coordinator	KAROLINSKA INSTITUTET Organization address address: Nobels Vag 5 city: STOCKHOLM postcode: 17177 website: www.ki.se contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.
Coordinator Country	Sweden [SE]
Total cost	247˙059 €
EC max contribution	247˙059 € (100%)
Programme	1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
Code Call	H2020-MSCA-IF-2017
Funding Scheme	MSCA-IF-GF
Starting year	2018
Duration (year-month-day)	from 2018-09-01 to 2021-08-31

Partnership

Take a look of project's partnership.

#	participants	country	role	EC contrib. [€]
1	KAROLINSKA INSTITUTET KAROLINSKA INSTITUTET Organization address address: Nobels Vag 5 city: STOCKHOLM postcode: 17177 website: www.ki.se contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	SE (STOCKHOLM)	coordinator	247˙059.00
2	THE ROCKEFELLER UNIVERSITY NOT FOR PROFIT CORPORATION THE ROCKEFELLER UNIVERSITY NOT FOR PROFIT CORPORATION Organization address address: YORK AVENUE 1230 city: NEW YORK postcode: 10065 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	US (NEW YORK)	partner	0.00

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Project objective

The aim of this action is to understand the mechanisms behind the susceptibility of enthorinal cortex II (ECII) neurons to neurofibrillary tangle (NFT) formation in Alzheimer´s disease. To do so we will modulate the expression of the genes that according to NetWAS (Network-wide Association Study) are more directly involved in NFT formation in ECII neurons.

Understanding why the pathological lesions that lead to neurodegeneration appear earlier in some specific neurons of the human brain is one of the major challenges in the neuroscience field.

Prof. Greengard´s lab has generated a transgenic mouse that allows the immunoprecipitation of ribosome-bound mRNAs specifically from ECII neurons (ECII-bacTRAP mice). We will perform AAV stereotaxic injections in the enthorinal cortex of these mice followed by RNA-seq to determine how the modulation of our target genes affects ECII neurons expression profile. We will also explore whether our intervention can influence ECII neurons susceptibility to NFT in P301S AD mice. The results obtained in mice will be validated by immunofluorescence and in situ hybridization studies in human samples from control and AD patients at different Braak stages.

Our results could add extremely relevant information on the mechanisms underlying AD pathogenesis and reveal these genes as new therapeutic targets for the disease.

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The information about "NEVULA" are provided by the European Opendata Portal: CORDIS opendata.