Opendata, web and dolomites

PREDATOR SIGNED

Revealing the cell biology of a predatory bacterium in space and time

Total Cost €

0

EC-Contrib. €

0

Partnership

0

Views

0

 PREDATOR project word cloud

Explore the words cloud of the PREDATOR project. It provides you a very rough idea of what is the project "PREDATOR" about.

imaging    species    innovative    daughter    bdellovibrio    largely    influence    progeny    fascinating    osmotic    fight    host    stability    thrives    antibiotics    textbook    grows    strains    uncover    combination    remarkable    living    contribution    feeds    inside    shed    envelope    standards    releasing    bacteriovorus    prey    filament    quantitative    initiates    cells    developmental    vivo    binary    unraveling    question    partitioned    genetic    successful    hunt    infection    periplasm    lack    mechanistic    pathogens    light    biological    negative    polarize    predatory    molecular    resistant    cell    single    live    revived    micro    niche    bacterium    mechanisms    models    event    polyploid    periplasmic    antibiotic    attracting    predator    model    genetics    questions    stands    space    discover    exquisite    tackle    despite    lifestyle    cycle    unexplored    digests    odd    pathogenic    biology    predation    canonical    copied    mysterious    division    bacterial    liberated    bacteria    entry    gram    remained   

Project "PREDATOR" data sheet

The following table provides information about the project.

Coordinator
UNIVERSITE CATHOLIQUE DE LOUVAIN 

Organization address
address: PLACE DE L UNIVERSITE 1
city: LOUVAIN LA NEUVE
postcode: 1348
website: www.uclouvain.be

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Belgium [BE]
 Total cost 1˙499˙688 €
 EC max contribution 1˙499˙688 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2018-STG
 Funding Scheme ERC-STG
 Starting year 2019
 Duration (year-month-day) from 2019-01-01   to  2023-12-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNIVERSITE CATHOLIQUE DE LOUVAIN BE (LOUVAIN LA NEUVE) coordinator 1˙499˙688.00

Map

 Project objective

The model predatory bacterium Bdellovibrio bacteriovorus feeds upon other Gram-negative bacteria, including pathogenic strains. Upon entry inside the periplasmic space of the prey envelope, B. bacteriovorus initiates an exquisite developmental program in which it digests the host resources while ensuring the osmotic stability of its niche. In the periplasm, the predator cell grows as a polyploid filament, before releasing a variable, odd or even number of daughter cells upon a non-binary division event. The progeny is then liberated to hunt for new prey. B. bacteriovorus is now attracting a revived attention as several in vivo models of infection established its promising “living antibiotic” potential. Despite this remarkable lifestyle, the fields of bacterial cell biology and antibiotics research still lack a comprehensive understanding of how this micro-predator thrives inside the envelope of other bacteria. Indeed, the molecular factors behind the non-canonical cell biology of B. bacteriovorus are still largely mysterious.

My goal is to tackle this question by unraveling the novel mechanisms that control key processes of the fascinating cell cycle of this bacterium, using a unique combination of quantitative live imaging of predation at the single-cell level, bacterial genetics and molecular biology. Specifically, I aim to (i) uncover how the genetic information is organized, copied and partitioned in a polyploid cell before non-binary division, (i) shed light on factors that polarize the predator cell, and (iii) discover prey envelope features that influence the predation cycle. Because the biology of B. bacteriovorus stands beyond textbook standards, our results will provide mechanistic insight into important biological questions that remained unexplored using “classical” model species. If successful, this project will advance bacterial cell biology, while offering an innovative contribution to the fight against antibiotics-resistant pathogens.

Are you the coordinator (or a participant) of this project? Plaese send me more information about the "PREDATOR" project.

For instance: the website url (it has not provided by EU-opendata yet), the logo, a more detailed description of the project (in plain text as a rtf file or a word file), some pictures (as picture files, not embedded into any word file), twitter account, linkedin page, etc.

Send me an  email (fabio@fabiodisconzi.com) and I put them in your project's page as son as possible.

Thanks. And then put a link of this page into your project's website.

The information about "PREDATOR" are provided by the European Opendata Portal: CORDIS opendata.

More projects from the same programme (H2020-EU.1.1.)

KineTic (2020)

New Reagents for Quantifying the Routing and Kinetics of T-cell Activation

Read More  

NEUTRAMENTH (2018)

A redox-neutral process for the cost-efficient and environmentally friendly production of Menthol

Read More  

E-DURA (2018)

Commercialization of novel soft neural interfaces

Read More