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PREDATOR SIGNED

Revealing the cell biology of a predatory bacterium in space and time

Total Cost €

0

EC-Contrib. €

0

Partnership

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 PREDATOR project word cloud

Explore the words cloud of the PREDATOR project. It provides you a very rough idea of what is the project "PREDATOR" about.

lack    tackle    strains    partitioned    event    fight    polyploid    negative    biology    molecular    textbook    niche    initiates    innovative    mechanisms    discover    shed    daughter    lifestyle    thrives    bacteriovorus    stands    envelope    bdellovibrio    quantitative    canonical    progeny    unexplored    bacterium    question    antibiotic    models    antibiotics    genetic    fascinating    biological    pathogenic    binary    feeds    space    liberated    contribution    osmotic    bacteria    imaging    despite    pathogens    cells    inside    predation    division    bacterial    attracting    cell    gram    periplasmic    model    influence    unraveling    remained    standards    species    single    successful    light    mysterious    polarize    resistant    uncover    odd    infection    entry    remarkable    revived    micro    periplasm    genetics    copied    developmental    host    largely    exquisite    live    predator    stability    cycle    releasing    prey    vivo    filament    questions    combination    hunt    digests    mechanistic    predatory    grows    living   

Project "PREDATOR" data sheet

The following table provides information about the project.

Coordinator
UNIVERSITE CATHOLIQUE DE LOUVAIN 

Organization address
address: PLACE DE L UNIVERSITE 1
city: LOUVAIN LA NEUVE
postcode: 1348
website: www.uclouvain.be

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Belgium [BE]
 Total cost 1˙499˙688 €
 EC max contribution 1˙499˙688 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2018-STG
 Funding Scheme ERC-STG
 Starting year 2019
 Duration (year-month-day) from 2019-01-01   to  2023-12-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNIVERSITE CATHOLIQUE DE LOUVAIN BE (LOUVAIN LA NEUVE) coordinator 1˙499˙688.00

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 Project objective

The model predatory bacterium Bdellovibrio bacteriovorus feeds upon other Gram-negative bacteria, including pathogenic strains. Upon entry inside the periplasmic space of the prey envelope, B. bacteriovorus initiates an exquisite developmental program in which it digests the host resources while ensuring the osmotic stability of its niche. In the periplasm, the predator cell grows as a polyploid filament, before releasing a variable, odd or even number of daughter cells upon a non-binary division event. The progeny is then liberated to hunt for new prey. B. bacteriovorus is now attracting a revived attention as several in vivo models of infection established its promising “living antibiotic” potential. Despite this remarkable lifestyle, the fields of bacterial cell biology and antibiotics research still lack a comprehensive understanding of how this micro-predator thrives inside the envelope of other bacteria. Indeed, the molecular factors behind the non-canonical cell biology of B. bacteriovorus are still largely mysterious.

My goal is to tackle this question by unraveling the novel mechanisms that control key processes of the fascinating cell cycle of this bacterium, using a unique combination of quantitative live imaging of predation at the single-cell level, bacterial genetics and molecular biology. Specifically, I aim to (i) uncover how the genetic information is organized, copied and partitioned in a polyploid cell before non-binary division, (i) shed light on factors that polarize the predator cell, and (iii) discover prey envelope features that influence the predation cycle. Because the biology of B. bacteriovorus stands beyond textbook standards, our results will provide mechanistic insight into important biological questions that remained unexplored using “classical” model species. If successful, this project will advance bacterial cell biology, while offering an innovative contribution to the fight against antibiotics-resistant pathogens.

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