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PREDATOR SIGNED

Revealing the cell biology of a predatory bacterium in space and time

Total Cost €

0

EC-Contrib. €

0

Partnership

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 PREDATOR project word cloud

Explore the words cloud of the PREDATOR project. It provides you a very rough idea of what is the project "PREDATOR" about.

polyploid    fascinating    liberated    live    vivo    polarize    stability    models    contribution    single    infection    entry    partitioned    uncover    releasing    mechanisms    resistant    exquisite    genetics    thrives    niche    binary    mechanistic    division    osmotic    fight    tackle    pathogens    mysterious    odd    prey    host    questions    initiates    discover    model    bacteria    inside    lack    predator    stands    envelope    strains    genetic    digests    remarkable    bacterial    innovative    micro    predatory    space    quantitative    lifestyle    antibiotic    canonical    attracting    daughter    biological    largely    molecular    negative    bacteriovorus    filament    despite    developmental    pathogenic    successful    feeds    living    event    standards    influence    hunt    remained    combination    revived    cycle    light    unexplored    question    grows    imaging    unraveling    predation    periplasmic    progeny    bacterium    periplasm    bdellovibrio    biology    copied    gram    species    antibiotics    cell    cells    shed    textbook   

Project "PREDATOR" data sheet

The following table provides information about the project.

Coordinator
UNIVERSITE CATHOLIQUE DE LOUVAIN 

Organization address
address: PLACE DE L UNIVERSITE 1
city: LOUVAIN LA NEUVE
postcode: 1348
website: www.uclouvain.be

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Belgium [BE]
 Total cost 1˙499˙688 €
 EC max contribution 1˙499˙688 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2018-STG
 Funding Scheme ERC-STG
 Starting year 2019
 Duration (year-month-day) from 2019-01-01   to  2023-12-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNIVERSITE CATHOLIQUE DE LOUVAIN BE (LOUVAIN LA NEUVE) coordinator 1˙499˙688.00

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 Project objective

The model predatory bacterium Bdellovibrio bacteriovorus feeds upon other Gram-negative bacteria, including pathogenic strains. Upon entry inside the periplasmic space of the prey envelope, B. bacteriovorus initiates an exquisite developmental program in which it digests the host resources while ensuring the osmotic stability of its niche. In the periplasm, the predator cell grows as a polyploid filament, before releasing a variable, odd or even number of daughter cells upon a non-binary division event. The progeny is then liberated to hunt for new prey. B. bacteriovorus is now attracting a revived attention as several in vivo models of infection established its promising “living antibiotic” potential. Despite this remarkable lifestyle, the fields of bacterial cell biology and antibiotics research still lack a comprehensive understanding of how this micro-predator thrives inside the envelope of other bacteria. Indeed, the molecular factors behind the non-canonical cell biology of B. bacteriovorus are still largely mysterious.

My goal is to tackle this question by unraveling the novel mechanisms that control key processes of the fascinating cell cycle of this bacterium, using a unique combination of quantitative live imaging of predation at the single-cell level, bacterial genetics and molecular biology. Specifically, I aim to (i) uncover how the genetic information is organized, copied and partitioned in a polyploid cell before non-binary division, (i) shed light on factors that polarize the predator cell, and (iii) discover prey envelope features that influence the predation cycle. Because the biology of B. bacteriovorus stands beyond textbook standards, our results will provide mechanistic insight into important biological questions that remained unexplored using “classical” model species. If successful, this project will advance bacterial cell biology, while offering an innovative contribution to the fight against antibiotics-resistant pathogens.

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