Opendata, web and dolomites

EVOCELFATE SIGNED

Evolution of cell fate specification modes in spiral cleavage

Total Cost €

0

EC-Contrib. €

0

Partnership

0

Views

0

 EVOCELFATE project word cloud

Explore the words cloud of the EVOCELFATE project. It provides you a very rough idea of what is the project "EVOCELFATE" about.

chromatin    conditional    spiral    incorporated    proteomics    gap    progenitor    structures    interactions    evolution    largely    remarkably    autonomous    fate    half    driving    modes    conditionally    bioinformatics    regulators    characters    phylogenetic    stereotypical    shifted    context    adult    species    maternal    cleavage    live    autonomously    rna    embryos    repeated    clade    mode    precocious    larvae    cleaving    adultation    comprehensively    almost    homologous    occurs    naturally    fill    unexplored    hypothesis    evolve    developmental    specify    imaging    closely    specification    phyla    cell    fundamental    molecular    core    supplied    lineages    embryonic    seq    fates    poorly    segregation    animal    uncover    insights    mechanisms    biology    repeatedly    tests    ancestral    programs    spiralian    posterodorsal    guided    questions    transcriptional    phenotypic    techniques    spiralia    differentially    inputs    variation    combine    evolutionary    experimental    oocytes   

Project "EVOCELFATE" data sheet

The following table provides information about the project.

Coordinator
QUEEN MARY UNIVERSITY OF LONDON 

Organization address
address: 327 MILE END ROAD
city: LONDON
postcode: E1 4NS
website: http://www.qmul.ac.uk

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country United Kingdom [UK]
 Total cost 1˙500˙000 €
 EC max contribution 1˙500˙000 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2018-STG
 Funding Scheme ERC-STG
 Starting year 2019
 Duration (year-month-day) from 2019-02-01   to  2024-01-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    QUEEN MARY UNIVERSITY OF LONDON UK (LONDON) coordinator 1˙500˙000.00

Map

 Project objective

Spiral cleavage is a highly stereotypical early embryonic program, and the ancestral, defining feature to Spiralia, a major phylogenetic clade including almost half of the animal phyla. Remarkably, spiral-cleaving embryos specify homologous cell fates (e.g. the progenitor cell of posterodorsal structures) conditionally –via cell interactions– or autonomously –via segregation of maternal inputs. This variation occurs naturally, even between closely related species, and has been related to the precocious formation of adult characters (adultation) in larvae of autonomous spiral-cleaving species. How spiralian lineages repeatedly shifted between these two cell fate specification modes is largely unexplored, because the mechanisms controlling spiral cleavage are still poorly characterized. This project tests the hypothesis that maternal chromatin and transcriptional regulators differentially incorporated in oocytes with autonomous spiral cleavage explain the evolution of this mode of cell fate specification. Through a comparative and phylogenetic-guided approach, we will combine bioinformatics, live imaging, and molecular and experimental techniques to: (i) Comprehensively identify differentially supplied maternal factors among spiral cleaving oocytes with distinct cell fate specification modes using comparative RNA-seq and proteomics; (ii) Uncover the developmental mechanisms driving conditional spiral cleavage, which is the ancestral embryonic mode; and (iii) Investigate how maternal chromatin and transcriptional regulators define early cell fates, and whether these factors account for the repeated evolution of autonomous specification modes. Our results will fill a large gap of knowledge in our understanding of spiral cleavage and its evolution. In a broader context, this project will deliver fundamental insights into two core questions in evolutionary developmental biology: how early embryonic programs evolve, and how they contribute to phenotypic change.

Are you the coordinator (or a participant) of this project? Plaese send me more information about the "EVOCELFATE" project.

For instance: the website url (it has not provided by EU-opendata yet), the logo, a more detailed description of the project (in plain text as a rtf file or a word file), some pictures (as picture files, not embedded into any word file), twitter account, linkedin page, etc.

Send me an  email (fabio@fabiodisconzi.com) and I put them in your project's page as son as possible.

Thanks. And then put a link of this page into your project's website.

The information about "EVOCELFATE" are provided by the European Opendata Portal: CORDIS opendata.

More projects from the same programme (H2020-EU.1.1.)

KineTic (2020)

New Reagents for Quantifying the Routing and Kinetics of T-cell Activation

Read More  

NEUTRAMENTH (2018)

A redox-neutral process for the cost-efficient and environmentally friendly production of Menthol

Read More  

OSIRIS (2020)

Automatic measurement of speech understanding using EEG

Read More