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EVOCELFATE SIGNED

Evolution of cell fate specification modes in spiral cleavage

Total Cost €

0

EC-Contrib. €

0

Partnership

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 EVOCELFATE project word cloud

Explore the words cloud of the EVOCELFATE project. It provides you a very rough idea of what is the project "EVOCELFATE" about.

evolution    oocytes    largely    progenitor    precocious    specification    questions    regulators    supplied    mechanisms    adult    fundamental    core    repeated    molecular    combine    inputs    autonomous    phylogenetic    differentially    mode    transcriptional    variation    live    cell    spiralian    tests    fill    conditionally    guided    shifted    ancestral    embryonic    spiralia    poorly    animal    larvae    clade    segregation    posterodorsal    species    driving    closely    chromatin    seq    evolve    incorporated    modes    maternal    interactions    fates    programs    uncover    embryos    autonomously    hypothesis    insights    remarkably    fate    comprehensively    rna    cleavage    proteomics    characters    adultation    evolutionary    occurs    phenotypic    biology    spiral    naturally    developmental    techniques    context    gap    stereotypical    lineages    homologous    specify    almost    half    phyla    structures    cleaving    conditional    repeatedly    imaging    bioinformatics    unexplored    experimental   

Project "EVOCELFATE" data sheet

The following table provides information about the project.

Coordinator
QUEEN MARY UNIVERSITY OF LONDON 

Organization address
address: 327 MILE END ROAD
city: LONDON
postcode: E1 4NS
website: http://www.qmul.ac.uk

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country United Kingdom [UK]
 Total cost 1˙500˙000 €
 EC max contribution 1˙500˙000 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2018-STG
 Funding Scheme ERC-STG
 Starting year 2019
 Duration (year-month-day) from 2019-02-01   to  2024-01-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    QUEEN MARY UNIVERSITY OF LONDON UK (LONDON) coordinator 1˙500˙000.00

Map

 Project objective

Spiral cleavage is a highly stereotypical early embryonic program, and the ancestral, defining feature to Spiralia, a major phylogenetic clade including almost half of the animal phyla. Remarkably, spiral-cleaving embryos specify homologous cell fates (e.g. the progenitor cell of posterodorsal structures) conditionally –via cell interactions– or autonomously –via segregation of maternal inputs. This variation occurs naturally, even between closely related species, and has been related to the precocious formation of adult characters (adultation) in larvae of autonomous spiral-cleaving species. How spiralian lineages repeatedly shifted between these two cell fate specification modes is largely unexplored, because the mechanisms controlling spiral cleavage are still poorly characterized. This project tests the hypothesis that maternal chromatin and transcriptional regulators differentially incorporated in oocytes with autonomous spiral cleavage explain the evolution of this mode of cell fate specification. Through a comparative and phylogenetic-guided approach, we will combine bioinformatics, live imaging, and molecular and experimental techniques to: (i) Comprehensively identify differentially supplied maternal factors among spiral cleaving oocytes with distinct cell fate specification modes using comparative RNA-seq and proteomics; (ii) Uncover the developmental mechanisms driving conditional spiral cleavage, which is the ancestral embryonic mode; and (iii) Investigate how maternal chromatin and transcriptional regulators define early cell fates, and whether these factors account for the repeated evolution of autonomous specification modes. Our results will fill a large gap of knowledge in our understanding of spiral cleavage and its evolution. In a broader context, this project will deliver fundamental insights into two core questions in evolutionary developmental biology: how early embryonic programs evolve, and how they contribute to phenotypic change.

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