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IM-ID SIGNED

Defining the intrinsic transcriptional programs and the microenvironmental signals tailoring lung Interstitial Macrophage IDentity

Total Cost €

0

EC-Contrib. €

0

Partnership

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 IM-ID project word cloud

Explore the words cloud of the IM-ID project. It provides you a very rough idea of what is the project "IM-ID" about.

implicated    homeostasis    host    basic    exhibit    nervous    attractive    mediated    critical    profile    organization    biological    innovative    little    local    macrophages    chemo    unmethylated    foundations    exposure    im    contribution    cpg    tolerogenic    id    population    combination    airway    sustain    tool    functional    regulators    prevent    spatial    elucidate    underscoring    functions    bulk    governing    asthma    immune    tissue    imprinted    differentiation    date    fine    demonstrated    aberrant    identity    limit    cholinergic    dimensional    protection    niche    epithelial    precursor    mechanisms    transcription    signature    shown    lung    implications    function    preventing    prevention    instructive    model    dna    allergic    precursors    signals    dys    diseases    allergens    fundamental    bacterial    macrophage    transgenic    ing    recruitment    tf    tuning    molecular    single    selectively    underlying    health    heterogeneity    expand    interstitial    cell    programs    precise    technologies    monocyte   

Project "IM-ID" data sheet

The following table provides information about the project.

Coordinator
UNIVERSITE DE LIEGE 

Organization address
address: PLACE DU 20 AOUT 7
city: LIEGE
postcode: 4000
website: www.ulg.ac.be

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Belgium [BE]
 Total cost 1˙500˙000 €
 EC max contribution 1˙500˙000 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2018-STG
 Funding Scheme ERC-STG
 Starting year 2019
 Duration (year-month-day) from 2019-01-01   to  2023-12-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNIVERSITE DE LIEGE BE (LIEGE) coordinator 1˙500˙000.00

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 Project objective

The mechanisms underlying lung homeostasis are of fundamental biological importance and have critical implications for the prevention of immune-mediated diseases such as asthma. We have demonstrated that lung Interstitial Macrophages (IM) exhibit a tolerogenic profile and are able to prevent and limit the development of aberrant immune responses against allergens, thus underscoring their role as crucial regulators of lung homeostasis. In addition, we have shown that IM could expand from monocyte precursors upon host exposure to bacterial unmethylated CpG-DNA, resulting in robust protection against allergic asthma. To date, however, IM have only been characterized as a bulk population in functional studies, and little is known about the tissue-instructive signals, specific transcription factors and differentiation programs which contribute to determining their identity (ID) and function, as proposed by the macrophage niche model. We have developed an innovative transgenic tool to selectively target IM which, in combination with high dimensional single cell technologies, will allow us to (1) define the precise ID of IM, i.e. their spatial organization, heterogeneity, molecular signature and the specific TF governing their differentiation and function; (2) investigate how IM ID is imprinted by the local niche to sustain lung homeostasis. Specifically, we aim to identify the epithelial cell-derived chemo-attractive signals controlling IM precursor recruitment and to elucidate the contribution of the lung cholinergic nervous system to IM ID and lung homeostasis. This research will increase our understanding of the basic mechanisms underlying the fine-tuning of tolerogenic IM and will thus provide robust foundations for novel IM-targeted approaches promoting health and preventing airway diseases in which IM (dys)functions have been implicated.

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