RiboInflam SIGNED
Assessing the role of ribosomes and mRNA translation in shaping the inflammatory response
Total Cost €
0EC-Contrib. €
0Partnership
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0RiboInflam project word cloud
Explore the words cloud of the RiboInflam project. It provides you a very rough idea of what is the project "RiboInflam" about.
Project "RiboInflam" data sheet
The following table provides information about the project.
| Coordinator |
INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE
Organization address contact info |
| Coordinator Country | France [FR] |
| Total cost | 1˙499˙720 € |
| EC max contribution | 1˙499˙720 € (100%) |
| Programme |
1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC)) |
| Code Call | ERC-2018-STG |
| Funding Scheme | ERC-STG |
| Starting year | 2019 |
| Duration (year-month-day) | from 2019-01-01 to 2023-12-31 |
Partnership
Take a look of project's partnership.
| # | ||||
|---|---|---|---|---|
| 1 | INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE | FR (PARIS) | coordinator | 1˙499˙720.00 |
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Project objective
Inflammation is a highly regulated process that acts as a first line of defense against pathogens infections. Triggered by cellular pattern recognition receptors (PRRs) that recognize specific microbial components and endogenous or exogenous non-microbial components, activation of inflammation induces a dynamic and coordinated gene expression program that leads to the production of cytokines and chemokines to attract effector cells to the site of infection. Although a robust inflammatory response is required for efficient clearance of pathogens, uncontrolled or prolonged inflammation can lead to inflammatory disorders such as septic shocks or to autoimmune diseases like lupus. Most studies have focused so far on the transcriptional control of the inflammatory gene expression program. However, post-transcriptional regulatory mechanisms involving mRNA splicing, mRNA decay or translation have also been described to control the inflammatory response. Among these, regulation of mRNA translation allows for rapid and reversible modulation of gene expression but its precise role and control mechanisms in the inflammatory response remain poorly understood. Using innovative technologies, our project aims at characterizing the role of ribosomes and mRNA translation in regulating the inflammatory response. In particular, we propose to identify the complete set of of ribosome accessory proteins and to determine their role in the context of “specialized ribosomes” with specific regulatory activities. We will also study the cross-talks between ribosomes and other cellular processes such as mRNA decay and uncover the role of mRNA editing in regulating translation during the inflammatory response. From this work, we expect to identify new regulatory mechanisms that orchestrate inflammation as well as cellular factors that could represent new therapeutic targets for the design of drugs modulating inflammation.
Publications
| year | authors and title | journal | last update |
|---|---|---|---|
| 2019 |
Guilherme Loss, Patricia Martins Simões, Florent Valour, Marina Farrel Cortês, Luiz Gonzaga, Marine Bergot, Sophie Trouillet-Assant, Jêrome Josse, Alan Diot, Emiliano Ricci, Ana Tereza Vasconcelos, Frédéric Laurent Staphylococcus aureus Small Colony Variants (SCVs): News From a Chronic Prosthetic Joint Infection published pages: , ISSN: 2235-2988, DOI: 10.3389/fcimb.2019.00363 |
Frontiers in Cellular and Infection Microbiology 9 | 2020-01-30 |
| 2019 |
Julieta Rivosecchi, Marc Larochelle, Camille Teste, Frédéric Grenier, Amélie Malapert, Emiliano P Ricci, Pascal Bernard, François Bachand, Vincent Vanoosthuyse Senataxin homologue Sen1 is required for efficient termination of RNA polymerase III transcription published pages: , ISSN: 0261-4189, DOI: 10.15252/embj.2019101955 |
The EMBO Journal 38/16 | 2020-01-30 |
| 2019 |
Aline Marnef, Anne-Laure Finoux, Coline Arnould, Emmanuelle Guillou, Virginie Daburon, Vincent Rocher, Thomas Mangeat, Philippe E. Mangeot, Emiliano P. Ricci, Gaëlle Legube A cohesin/HUSH- and LINC-dependent pathway controls ribosomal DNA double-strand break repair published pages: 1175-1190, ISSN: 0890-9369, DOI: 10.1101/gad.324012.119 |
Genes & Development 33/17-18 | 2020-01-30 |
| 2019 |
Philippe E. Mangeot, Valérie Risson, Floriane Fusil, Aline Marnef, Emilie Laurent, Juliana Blin, Virginie Mournetas, Emmanuelle Massouridès, Thibault J. M. Sohier, Antoine Corbin, Fabien Aubé, Marie Teixeira, Christian Pinset, Laurent Schaeffer, Gaëlle Legube, François-Loïc Cosset, Els Verhoeyen, Théophile Ohlmann, Emiliano P. Ricci Genome editing in primary cells and in vivo using viral-derived Nanoblades loaded with Cas9-sgRNA ribonucleoproteins published pages: , ISSN: 2041-1723, DOI: 10.1038/s41467-018-07845-z |
Nature Communications 10/1 | 2019-04-18 |
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