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BRuSH SIGNED

Oral bacteria as determinants for respiratory health

Total Cost €

0

EC-Contrib. €

0

Partnership

0

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 BRuSH project word cloud

Explore the words cloud of the BRuSH project. It provides you a very rough idea of what is the project "BRuSH" about.

types    effect    cells    antagonistic    balance    significance    cell    lipopolysaccharide    disease    bacteria    functional    epithelial    predict    saliva    microbiome    exposing    synthesized    intervention    health    producers    longitudinally    lung    negative    hypothesis    feasible    designed    oral    programs    dust    dominated    lower    species    chemically    bioinformatics    microbiota    cavity    community    gram    gain    mice    data    lps    shown    annotation    lungs    drive    communities    healthy    periodontitis    pathogens    human    raw    relationship    inflammatory    bacterial    patients    bronchial    tract    assign    pro    sequences    causal    producing    potency    potent    cluster    individuals    population    prove    genome    time    models    respiratory    preventing    tool    induce    dna    optimizing    function    host    commensal    epidemiological    samples    brush    play    biological    asthma    lipid    gateway    immune    asthmatic    weak    assays    composition   

Project "BRuSH" data sheet

The following table provides information about the project.

Coordinator
UNIVERSITETET I BERGEN 

Organization address
address: MUSEPLASSEN 1
city: BERGEN
postcode: 5020
website: www.uib.no

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Norway [NO]
 Total cost 1˙499˙938 €
 EC max contribution 1˙499˙938 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2018-STG
 Funding Scheme ERC-STG
 Starting year 2019
 Duration (year-month-day) from 2019-01-01   to  2023-12-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNIVERSITETET I BERGEN NO (BERGEN) coordinator 1˙499˙938.00

Map

 Project objective

The oral cavity is the gateway to the lower respiratory tract, and oral bacteria are likely to play a role in lung health. This may be the case for pathogens as well as commensal bacteria and the balance between species. The oral bacterial community of patients with periodontitis is dominated by gram-negative bacteria and a higher lipopolysaccharide (LPS) activity than in healthy microbiota. Furthermore, bacteria with especially potent pro-inflammatory LPS have been shown to be more common in the lungs of asthmatic than in healthy individuals. The working hypothesis of BRuSH is that microbiome communities dominated by LPS-producing bacteria which induce a particularly strong pro-inflammatory immune response in the host, will have a negative effect on respiratory health. I will test this hypothesis in two longitudinally designed population-based lung health studies. I aim to identify whether specific bacterial composition and types of LPS producing bacteria in oral and dust samples predict lung function and respiratory health over time; and if the different types of LPS-producing bacteria affect LPS in saliva saliva and dust. BRuSH will apply functional genome annotation that can assign biological significance to raw bacterial DNA sequences. With this bioinformatics tool I will cluster microbiome data into various LPS-producers: bacteria with LPS with strong inflammatory effects and others with weak- or antagonistic effects. The epidemiological studies will be supported by mice-models of asthma and cell assays of human bronchial epithelial cells, by exposing mice and bronchial cells to chemically synthesized Lipid A (the component that drive the LPS-induced immune responses) of various potency. The goal of BRuSH is to prove a causal relationship between oral microbiome and lung health, and gain knowledge that will enable us to make oral health a feasible target for intervention programs aimed at optimizing lung health and preventing respiratory disease.

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The information about "BRUSH" are provided by the European Opendata Portal: CORDIS opendata.

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