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BRuSH SIGNED

Oral bacteria as determinants for respiratory health

Total Cost €

0

EC-Contrib. €

0

Partnership

0

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 BRuSH project word cloud

Explore the words cloud of the BRuSH project. It provides you a very rough idea of what is the project "BRuSH" about.

composition    cell    antagonistic    immune    healthy    lipopolysaccharide    data    health    assign    dust    pathogens    lungs    microbiota    play    functional    lps    tool    gram    brush    respiratory    potent    hypothesis    gateway    predict    chemically    shown    sequences    inflammatory    models    genome    individuals    community    synthesized    lower    producing    microbiome    bacterial    function    weak    designed    pro    population    raw    time    dominated    assays    types    human    exposing    species    periodontitis    bioinformatics    lung    causal    saliva    epithelial    communities    effect    bronchial    epidemiological    longitudinally    drive    negative    cluster    mice    prove    bacteria    relationship    significance    gain    preventing    potency    optimizing    lipid    feasible    balance    disease    oral    producers    annotation    asthma    host    tract    cells    commensal    samples    programs    intervention    dna    asthmatic    patients    cavity    induce    biological   

Project "BRuSH" data sheet

The following table provides information about the project.

Coordinator
UNIVERSITETET I BERGEN 

Organization address
address: MUSEPLASSEN 1
city: BERGEN
postcode: 5020
website: www.uib.no

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Norway [NO]
 Total cost 1˙499˙938 €
 EC max contribution 1˙499˙938 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2018-STG
 Funding Scheme ERC-STG
 Starting year 2019
 Duration (year-month-day) from 2019-01-01   to  2023-12-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNIVERSITETET I BERGEN NO (BERGEN) coordinator 1˙499˙938.00

Map

 Project objective

The oral cavity is the gateway to the lower respiratory tract, and oral bacteria are likely to play a role in lung health. This may be the case for pathogens as well as commensal bacteria and the balance between species. The oral bacterial community of patients with periodontitis is dominated by gram-negative bacteria and a higher lipopolysaccharide (LPS) activity than in healthy microbiota. Furthermore, bacteria with especially potent pro-inflammatory LPS have been shown to be more common in the lungs of asthmatic than in healthy individuals. The working hypothesis of BRuSH is that microbiome communities dominated by LPS-producing bacteria which induce a particularly strong pro-inflammatory immune response in the host, will have a negative effect on respiratory health. I will test this hypothesis in two longitudinally designed population-based lung health studies. I aim to identify whether specific bacterial composition and types of LPS producing bacteria in oral and dust samples predict lung function and respiratory health over time; and if the different types of LPS-producing bacteria affect LPS in saliva saliva and dust. BRuSH will apply functional genome annotation that can assign biological significance to raw bacterial DNA sequences. With this bioinformatics tool I will cluster microbiome data into various LPS-producers: bacteria with LPS with strong inflammatory effects and others with weak- or antagonistic effects. The epidemiological studies will be supported by mice-models of asthma and cell assays of human bronchial epithelial cells, by exposing mice and bronchial cells to chemically synthesized Lipid A (the component that drive the LPS-induced immune responses) of various potency. The goal of BRuSH is to prove a causal relationship between oral microbiome and lung health, and gain knowledge that will enable us to make oral health a feasible target for intervention programs aimed at optimizing lung health and preventing respiratory disease.

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The information about "BRUSH" are provided by the European Opendata Portal: CORDIS opendata.

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