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ERGO SIGNED

Breaking down the wall between human health and environmental testing of endocrine disrupters: EndocRine Guideline Optimisation

Total Cost €

EC-Contrib. €

Partnership

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ERGO project word cloud

Explore the words cloud of the ERGO project. It provides you a very rough idea of what is the project "ERGO" about.

inclusion thyroid modeling classes safety extrapolate lower receptor gonadal standardized humans health industry mammals breaking class tg tgs proof endocrine shift chemicals amphibian suitable tool aop axes fish battery simpler biotransformation hazard td vivo pituitary foundation strategy outcomes assays effect mammalian data faster regulators vertebrate connecting risk biomarkers cross extrapolation oecd edc identification versa guidelines hypothalamus cheaper environmental disrupting safer network hpg beneficial regulations scientifically retinoid predictive conserved responsive adverse tests axis ergo edcs outcome regulation vice silico mechanisms successful free regulatory wall validate plausible human tdc rxr endpoints iata paradigm vitro

Project "ERGO" data sheet

The following table provides information about the project.

Coordinator	SYDDANSK UNIVERSITET Organization address address: CAMPUSVEJ 55 city: ODENSE M postcode: 5230 website: www.sdu.dk contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.
Coordinator Country	Denmark [DK]
Total cost	6˙998˙388 €
EC max contribution	5˙992˙437 € (86%)
Programme	1. H2020-EU.3.1.1. (Understanding health, wellbeing and disease)
Code Call	H2020-SC1-2018-Single-Stage-RTD
Funding Scheme	RIA
Starting year	2019
Duration (year-month-day)	from 2019-01-01 to 2023-12-31

Partnership

Take a look of project's partnership.

#	participants	country	role	EC contrib. [€]
1	SYDDANSK UNIVERSITET SYDDANSK UNIVERSITET Organization address address: CAMPUSVEJ 55 city: ODENSE M postcode: 5230 website: www.sdu.dk contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	DK (ODENSE M)	coordinator	1˙273˙185.00
2	RUPRECHT-KARLS-UNIVERSITAET HEIDELBERG RUPRECHT-KARLS-UNIVERSITAET HEIDELBERG Organization address address: SEMINARSTRASSE 2 city: HEIDELBERG postcode: 69117 website: www.uni-heidelberg.de contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	DE (HEIDELBERG)	participant	695˙665.00
3	UNIVERSITEIT ANTWERPEN UNIVERSITEIT ANTWERPEN Organization address address: PRINSSTRAAT 13 city: ANTWERPEN postcode: 2000 website: www.ua.ac.be contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	BE (ANTWERPEN)	participant	610˙065.00
4	ECOLE NORMALE SUPERIEURE DE LYON ECOLE NORMALE SUPERIEURE DE LYON Organization address address: PARVIS RENE DESCARTES 15 city: LYON postcode: 69342 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	FR (LYON)	participant	534˙875.00
5	CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS Organization address address: RUE MICHEL ANGE 3 city: PARIS postcode: 75794 website: www.cnrs.fr contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	FR (PARIS)	participant	468˙040.00
6	HELMHOLTZ-ZENTRUM FUR UMWELTFORSCHUNG GMBH - UFZ HELMHOLTZ-ZENTRUM FUR UMWELTFORSCHUNG GMBH - UFZ Organization address address: PERMOSERSTRASSE 15 city: LEIPZIG postcode: 4318 website: www.ufz.de contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	DE (LEIPZIG)	participant	450˙000.00
7	Masarykova univerzita Masarykova univerzita Organization address address: Zerotinovo namesti 9 city: BRNO STRED postcode: 60177 website: http://www.muni.cz contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	CZ (BRNO STRED)	participant	417˙875.00
8	AARHUS UNIVERSITET AARHUS UNIVERSITET Organization address address: NORDRE RINGGADE 1 city: AARHUS C postcode: 8000 website: www.au.dk contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	DK (AARHUS C)	participant	411˙120.00
9	FORSCHUNGSVERBUND BERLIN EV FORSCHUNGSVERBUND BERLIN EV Organization address address: RUDOWER CHAUSSEE 17 city: BERLIN postcode: 12489 website: www.fv-berlin.de contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	DE (BERLIN)	participant	410˙500.00
10	AquaTT UETP Ltd AquaTT UETP Ltd Organization address address: PLEASANTS STREET OLYMPIC HOUSE UNIT 8 SECOND FLOOR city: DUBLIN postcode: 8 website: www.aquatt.ie contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	IE (DUBLIN)	participant	324˙875.00
11	UMWELTBUNDESAMT UMWELTBUNDESAMT Organization address address: Woerlitzer Platz 1 city: DESSAU-ROSSLAU postcode: 6844 website: www.uba.de contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	DE (DESSAU-ROSSLAU)	participant	206˙675.00
12	PETER MATTHIESSEN PETER MATTHIESSEN Organization address address: DOLFAN BARN BEULAH city: LLANWRTYD WELLS postcode: LD5 4UE website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	UK (LLANWRTYD WELLS)	participant	104˙249.00
13	BASF SE BASF SE Organization address address: CARL BOSCH STRASSE 38 city: LUDWIGSHAFEN AM RHEIN postcode: 67063 website: www.basf.com contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	DE (LUDWIGSHAFEN AM RHEIN)	participant	85˙312.00
14	Dow AgroSciences LLC Dow AgroSciences LLC Organization address address: Zionsville Road 9330 city: INDIANAPOLIS postcode: 46268-1054 website: www.dowagro.com/homepage/ contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	US (INDIANAPOLIS)	participant	0.00
15	L'OREAL SA L'OREAL SA Organization address address: 14 RUE ROYALE city: PARIS postcode: 75008 website: www.loreal.com contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	FR (PARIS)	participant	0.00
16	PUBLIC UNIVERSITY CORPORATION YOKOHAMA CITY UNIVERSITY PUBLIC UNIVERSITY CORPORATION YOKOHAMA CITY UNIVERSITY Organization address address: 22-2 SETO KANAZAWA-KU city: YOKOHAMA postcode: 236 0027 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	JP (YOKOHAMA)	participant	0.00

Map

Project objective

ERGO presents a new approach that will support a paradigm shift in the regulatory use of standardized test guidelines (TGs) by breaking the existing wall between mammalian and non-mammalian vertebrate testing and assessment of endocrine disrupting chemicals (EDCs). The highly conserved thyroid system will be used as the “proof of concept”, but also other conserved endocrine axes/systems such as the Retinoid X Receptor (RXR) and the Hypothalamus Pituitary Gonadal (HPG) axis can be adapted to the cross-vertebrate class approach. ERGO will investigate a battery of draft in vitro assays and evaluate thyroid-responsive biomarkers and endpoints (B/E) suitable for extrapolation of effects from fish and amphibian tests to humans and other mammals (and vice versa) and finally validate successful B/E for inclusion in existing in vivo or new in vitro OECD TGs. A cross-class adverse outcome pathway (AOP) network will provide the scientifically plausible and evidence-based foundation for the selection of B/E in lower vertebrate assays predictive of human health outcomes. In silico modeling and biotransformation data will support cross-vertebrate class effect extrapolation. Major outcomes of ERGO will be: 1) New thyroid-related B/E for inclusion in OECD TGs for improved identification of TDC. 2) An Integrated Approach to Testing and Assessment (IATA) of chemicals for TD based on a multi-class vertebrate AOP network connecting endocrine mechanisms in one vertebrate class to adverse outcomes in another class for safer regulation of EDCs. 3) A tool for TG end users, such as regulators and industry, to extrapolate thyroid effects between vertebrate classes. Implementation of the ERGO IATA strategy in regulations of EDC will make hazard and risk assessment faster, cheaper, simpler and safer and support industry in the development of EDC-free products beneficial for environmental and human safety.

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