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FURTHER SIGNED

Focused Ultrasound and RadioTHERapy for Noninvasive Palliative Pain Treatment in Patients with Bone Metastasis

Total Cost €

EC-Contrib. €

Partnership

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FURTHER project word cloud

Explore the words cloud of the FURTHER project. It provides you a very rough idea of what is the project "FURTHER" about.

options standard induces life randomized alternative rct benefit devastating difficult model hifu therapy preliminary integration international arm effectiveness consequence care 216 tolerated recommendations substantially administer routine days 70 rates additional metastases metastatic equal palliation manifestation whom inadequate bone explore economic relief usually pain patients spread rt pilot option takes purpose urgently socio givers suggest context survival barriers palliate cancer incidence living mr prediction inducing rapid trial rising weeks map detrimental treatment radiation quality strategy lacking

Project "FURTHER" data sheet

The following table provides information about the project.

Coordinator	UNIVERSITAIR MEDISCH CENTRUM UTRECHT Organization address address: HEIDELBERGLAAN 100 city: UTRECHT postcode: 3584 CX website: www.umcutrecht.nl contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.
Coordinator Country	Netherlands [NL]
Total cost	4˙018˙187 €
EC max contribution	3˙998˙125 € (100%)
Programme	1. H2020-EU.3.1.3. (Treating and managing disease)
Code Call	H2020-SC1-2018-Single-Stage-RTD
Funding Scheme	RIA
Starting year	2019
Duration (year-month-day)	from 2019-01-01 to 2023-12-31

Partnership

Take a look of project's partnership.

#	participants	country	role	EC contrib. [€]
1	UNIVERSITAIR MEDISCH CENTRUM UTRECHT UNIVERSITAIR MEDISCH CENTRUM UTRECHT Organization address address: HEIDELBERGLAAN 100 city: UTRECHT postcode: 3584 CX website: www.umcutrecht.nl contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	NL (UTRECHT)	coordinator	971˙312.00
2	THE INSTITUTE OF CANCER RESEARCH: ROYAL CANCER HOSPITAL THE INSTITUTE OF CANCER RESEARCH: ROYAL CANCER HOSPITAL Organization address address: OLD BROMPTON ROAD 123 city: LONDON postcode: SW7 3RP website: www.icr.ac.uk contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	UK (LONDON)	participant	756˙192.00
3	KLINIKUM DER UNIVERSITAET ZU KOELN KLINIKUM DER UNIVERSITAET ZU KOELN Organization address address: Kerpener Strasse 62 city: KOELN postcode: 50937 website: www.uk-koeln.de contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	DE (KOELN)	participant	646˙415.00
4	VARSINAIS-SUOMEN SAIRAANHOITOPIIRIN KUNTAYHTYMA VARSINAIS-SUOMEN SAIRAANHOITOPIIRIN KUNTAYHTYMA Organization address address: KIINAMYLLYNKATU 4-8 city: TURKU postcode: 20520 website: www.tykd.fin/en contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	FI (TURKU)	participant	430˙250.00
5	STICHTING ISALA KLINIEKEN STICHTING ISALA KLINIEKEN Organization address address: DOKTER VAN HEESWEG 2 city: ZWOLLE postcode: 8025 AB website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	NL (ZWOLLE)	participant	386˙250.00
6	ISTITUTO ORTOPEDICO RIZZOLI ISTITUTO ORTOPEDICO RIZZOLI Organization address address: VIA DI BARBIANO 1/10 city: BOLOGNA postcode: 40136 website: www.ior.it contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	IT (BOLOGNA)	participant	280˙835.00
7	CENTRO SA.NA. SERVIZI SANITARI PRIVATI SRL CENTRO SA.NA. SERVIZI SANITARI PRIVATI SRL Organization address address: VIA PESCHIERA SNC city: APRILIA postcode: 4011 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	IT (APRILIA)	participant	260˙625.00
8	UNIVERSITA DEGLI STUDI DI ROMA LA SAPIENZA UNIVERSITA DEGLI STUDI DI ROMA LA SAPIENZA Organization address address: Piazzale Aldo Moro 5 city: ROMA postcode: 185 website: www.uniroma1.it contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	IT (ROMA)	participant	158˙750.00
9	ALMA MATER STUDIORUM - UNIVERSITA DI BOLOGNA ALMA MATER STUDIORUM - UNIVERSITA DI BOLOGNA Organization address address: VIA ZAMBONI 33 city: BOLOGNA postcode: 40126 website: www.unibo.it contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	IT (BOLOGNA)	participant	107˙495.00
10	FOCUSED ULTRASOUND FOUNDATION FOCUSED ULTRASOUND FOUNDATION Organization address address: CEDARS COURT city: CHARLOTTESVILLE postcode: 22903 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	US (CHARLOTTESVILLE)	participant	0.00

Map

Project objective

Bone metastases are a common manifestation of advanced cancer, with pain as a devastating consequence. Due to rising cancer incidence rates and improving survival, the number of cancer patients living long enough to develop bone metastases is increasing rapidly. Metastatic bone pain is difficult to manage and has a detrimental impact on quality of life of patients, their partners and care-givers.

Radiation therapy (RT), the standard treatment for palliation of metastatic bone pain, is easy to administer and well tolerated. However, RT is only effective in 60-70% of patients and usually takes four weeks before inducing pain response. Inadequate pain relief is therefore common and alternative treatment options are urgently needed.

Pain palliation may be substantially improved by including MR-HIFU as alternative or in addition to RT. Preliminary studies suggest that MR-HIFU induces rapid pain relief (within days), and may palliate pain in patients in whom RT is not effective. Currently, strong evidence and context is lacking for wide-spread implementation of MR-HIFU into routine care.

The FURTHER project aims to demonstrate (cost)effectiveness of MR-HIFU as an alternative or additional treatment option to relief metastatic bone pain. For this purpose, a three arm international randomized controlled trial (RCT) including 216 patients will be conducted comparing early and late pain response in patients treated with RT only, MR-HIFU only, and RT with MR-HIFU. A prediction model will be developed to identify patients who are likely to benefit from MR-HIFU in order to allow (cost-) effective use of the treatment. A pilot pathway RCT will be conducted to explore the effectiveness of MR-HIFU as part of a comprehensive pain management strategy. Finally, FURTHER will map and analyse socio-economic barriers for integration of MR-HIFU in routine care in the wider European context and make recommendations on how to provide equal access to this promising new treatment.

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The information about "FURTHER" are provided by the European Opendata Portal: CORDIS opendata.