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GEMMA SIGNED

Genome, Environment, Microbiome & Metabolome in Autism: an integrated multi-omic systems biology approach to identify biomarkers for personalized treatment and primary prevention of Autism Spectr

Total Cost €

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EC-Contrib. €

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Partnership

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GEMMA project word cloud

Explore the words cloud of the GEMMA project. It provides you a very rough idea of what is the project "GEMMA" about.

solid interception time homeostasis progression mechanistically cohort relation blood autistic collect pro microbiome abnormal aid outcome disorders diagnostic followed multiomic intervention epigenetic stools prospectively treatment models patient prevention shift biobank families gut data pathogenesis barrier evaluation functions symbiotic identification microbiota risk environmental link infants phenotypes children murine causing tools 600 profile biomarkers manipulate biospecimens metabolic re generating immune gemma paradigm administration combine urine composition transplanted disease function modulate stratification human humanized ultimately 16 mechanistic onset first omic proved personalized exploited prediction samples stool proband suspected modifications birth recruited asd possibility interplay genome collected clinical spectrum attempt dynamic complete saliva

Project "GEMMA" data sheet

The following table provides information about the project.

Coordinator	FONDAZIONE EBRIS Organization address address: VIA DE RENZI 1 city: SALERNO postcode: 84125 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.
Coordinator Country	Italy [IT]
Total cost	14˙225˙757 €
EC max contribution	14˙225˙757 € (100%)
Programme	1. H2020-EU.3.1.2. (Preventing disease)
Code Call	H2020-SC1-2018-Single-Stage-RTD
Funding Scheme	RIA
Starting year	2019
Duration (year-month-day)	from 2019-01-01 to 2023-12-31

Partnership

Take a look of project's partnership.

#	participants	country	role	EC contrib. [€]
1	FONDAZIONE EBRIS FONDAZIONE EBRIS Organization address address: VIA DE RENZI 1 city: SALERNO postcode: 84125 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	IT (SALERNO)	coordinator	2˙035˙531.00
2	NATIONAL UNIVERSITY OF IRELAND GALWAY NATIONAL UNIVERSITY OF IRELAND GALWAY Organization address address: UNIVERSITY ROAD city: Galway postcode: H91 website: www.nuigalway.ie contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	IE (Galway)	participant	1˙663˙750.00
3	THE GENERAL HOSPITAL CORPORATION THE GENERAL HOSPITAL CORPORATION Organization address address: FRUIT STREET 55 city: BOSTON MA postcode: 2114 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	US (BOSTON MA)	participant	1˙256˙468.00
4	AZIENDA SANITARIA LOCALE SALERNO AZIENDA SANITARIA LOCALE SALERNO Organization address address: VIA NIZZA 146 city: SALERNO postcode: 84124 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	IT (SALERNO)	participant	1˙133˙375.00
5	INSTITUT NATIONAL DE RECHERCHE POUR L'AGRICULTURE, L'ALIMENTATION ET L'ENVIRONNEMENT INSTITUT NATIONAL DE RECHERCHE POUR L'AGRICULTURE, L'ALIMENTATION ET L'ENVIRONNEMENT Organization address address: Rue De L'Universite 147 city: PARIS CEDEX 07 postcode: 75338 website: www.inra.fr contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	FR (PARIS CEDEX 07)	participant	1˙060˙617.00
6	UNIVERSITEIT UTRECHT UNIVERSITEIT UTRECHT Organization address address: HEIDELBERGLAAN 8 city: UTRECHT postcode: 3584 CS website: www.uu.nl contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	NL (UTRECHT)	participant	881˙116.00
7	IMPERIAL COLLEGE OF SCIENCE TECHNOLOGY AND MEDICINE IMPERIAL COLLEGE OF SCIENCE TECHNOLOGY AND MEDICINE Organization address address: SOUTH KENSINGTON CAMPUS EXHIBITION ROAD city: LONDON postcode: SW7 2AZ website: http://www.imperial.ac.uk/ contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	UK (LONDON)	participant	832˙812.00
8	NUTRICIA RESEARCH BV NUTRICIA RESEARCH BV Organization address address: UPPSALALAAN 12 city: UTRECHT postcode: 3584 CT website: www.numico.com contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	NL (UTRECHT)	participant	812˙423.00
9	JOHNS HOPKINS UNIVERSITY JOHNS HOPKINS UNIVERSITY Organization address address: NORTH CHARLES STREET 3400 city: BALTIMORE postcode: 21218 website: www.hopkinsmedicine.org contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	US (BALTIMORE)	participant	747˙212.00
10	EUFORMATICS OY EUFORMATICS OY Organization address address: TEKNIIKANTIE 12 city: ESPOO postcode: 2150 website: www.euformatics.com contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	FI (ESPOO)	participant	728˙437.00
11	TAMPEREEN KORKEAKOULUSAATIO SR TAMPEREEN KORKEAKOULUSAATIO SR Organization address address: KALEVANTIE 4 city: TAMPERE postcode: 33100 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	FI (TAMPERE)	participant	558˙125.00
12	MEDINOK SPA MEDINOK SPA Organization address address: VIA PALAZZIELLO SNC city: VOLLA postcode: 80040 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	IT (VOLLA)	participant	549˙375.00
13	BIO MODELING SYSTEMS OU BMSYSTEMS BIO MODELING SYSTEMS OU BMSYSTEMS Organization address address: 3 RUE DE L'ARRIVEE city: Paris postcode: 75015 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	FR (Paris)	participant	548˙125.00
14	CONSIGLIO NAZIONALE DELLE RICERCHE CONSIGLIO NAZIONALE DELLE RICERCHE Organization address address: PIAZZALE ALDO MORO 7 city: ROMA postcode: 185 website: www.cnr.it contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	IT (ROMA)	participant	544˙375.00
15	INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE Organization address address: RUE DE TOLBIAC 101 city: PARIS postcode: 75654 website: www.inserm.fr contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	FR (PARIS)	participant	447˙762.00
16	THEOREO SRL THEOREO SRL Organization address address: VIA DEGLI ULIVI, 3 city: MONTECORVINO PUGLIANO postcode: 84090 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	IT (MONTECORVINO PUGLIANO)	participant	426˙250.00
17	TAMPEREEN YLIOPISTO TAMPEREEN YLIOPISTO Organization address address: Kalevantie 4 city: TAMPERE postcode: 33014 website: www.uta.fi contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	FI (TAMPERE)	participant	0.00

Map

Project objective

GEMMA will be the first project to combine a multi-omic approach with robust environmental data to exploit the analysis of the composition and function of the microbiome for personalized treatment and, ultimately, disease interception in infants at risk of Autistic Spectrum Disorders (ASD) . The project will provide solid mechanistic evidence of the disease onset and progression in relation to dynamic changes in abnormal gut microbiota causing epigenetic modifications controlling gut barrier and immune functions, based on the in-depth evaluation of 600 infants at risk observed from birth and followed over time. These data will be integrated with pre-clinical studies to mechanistically link human microbiota composition/function with clinical outcome through humanized murine models transplanted with stools obtained from the ASD proband patient of recruited families. The project will support novel personalized prediction (personalized treatment) and disease interception (prevention) approaches that attempt to modulate gut microbiota to re-establish/maintain immune homeostasis. The biomarkers identified in this project will contribute to a better understanding of the pathogenesis of ASD in at-risk children and the possibility to manipulate the microbiota through pre/pro/symbiotic administration for prevention and treatment, a complete paradigm shift in ASD pathogenesis and early intervention. The identification of specific ASD metabolic phenotypes will further aid to define biomarkers that can be used as diagnostic tools and patient stratification models for other conditions in which the interplay between genome, microbiome and metabolic profile has been suspected or proved. Finally, the project will collect biospecimens from a cohort of 600 infants as risk of ASD observed from birth, generating a unique biobank of 16,000 blood, stool, urine and saliva samples prospectively collected that can be exploited in future multiomic studies.

Deliverables

List of deliverables.
OmnomicsNGS v2 release	Demonstrators, pilots, prototypes	2020-04-25 10:50:00
Genome, epigenome and immune function interplay summary of hypothesis	Documents, reports	2020-04-25 10:50:00
Pre-clinical study ethical approval report	Documents, reports	2020-04-25 10:50:00
Updated state of the art report	Documents, reports	2020-04-25 10:50:00
Microbiome, metabolome and immune function interplay summary of hypothesis	Documents, reports	2020-04-25 10:50:00
Pre-clinical study 3/1 report	Documents, reports	2020-04-25 10:50:00
External project website	Websites, patent fillings, videos etc.	2020-04-25 10:50:00
Final clinical protocols	Documents, reports	2020-04-25 10:50:00
Open data management plan	Open Research Data Pilot	2020-04-25 10:50:00

Take a look to the deliverables list in detail: detailed list of GEMMA deliverables.

Publications

List of publications.
year	authors and title	journal	last update
2019	Noemi Di Nanni, Matteo Bersanelli, Francesca Anna Cupaioli, Luciano Milanesi, Alessandra Mezzelani, Ettore Mosca Network-Based Integrative Analysis of Genomics, Epigenomics and Transcriptomics in Autism Spectrum Disorders published pages: 3363, ISSN: 1422-0067, DOI: 10.3390/ijms20133363	International Journal of Molecular Sciences 20/13	2020-04-25
2019	Leonardo Emberti Gialloreti, Luigi Mazzone, Arianna Benvenuto, Alessio Fasano, Alicia Garcia Alcon, Aletta Kraneveld, Romina Moavero, Raanan Raz, Maria Pia Riccio, Martina Siracusano, Ditza A. Zachor, Marina Marini, Paolo Curatolo Risk and Protective Environmental Factors Associated with Autism Spectrum Disorder: Evidence-Based Principles and Recommendations published pages: 217, ISSN: 2077-0383, DOI: 10.3390/jcm8020217	Journal of Clinical Medicine 8/2	2020-04-25

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