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Opendata, web and dolomites

FuncMAB SIGNED

High-throughput single-cell phenotypic analysis of functional antibody repertoires

Total Cost €

EC-Contrib. €

Partnership

Views

FuncMAB project word cloud

Explore the words cloud of the FuncMAB project. It provides you a very rough idea of what is the project "FuncMAB" about.

functions vary vaccine generating play innovative presently vaccination technologies components individual recognize combined variations function single vaccinations threat successful evolutionary consequently poorly immune lack sufficiently varying cell linked protective biophysical bioassays analysed interactions antibodies epitope protection quantitative analysing forefront resolution mechanisms vaccines complexity heterogeneous nature herein repertoire trigger followed mostly team data depending affinity immunological threads prime influence encounters variant throughput generate propels binding repertoires generation evolution injection methodical functional antigen antibody time specificity host funcmab

Project "FuncMAB" data sheet

The following table provides information about the project.

Coordinator	EIDGENOESSISCHE TECHNISCHE HOCHSCHULE ZUERICH Organization address address: Raemistrasse 101 city: ZUERICH postcode: 8092 website: https://www.ethz.ch/de.html contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.
Coordinator Country	Switzerland [CH]
Total cost	1˙500˙000 €
EC max contribution	1˙500˙000 € (100%)
Programme	1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
Code Call	ERC-2018-STG
Funding Scheme	ERC-STG
Starting year	2019
Duration (year-month-day)	from 2019-02-01 to 2024-01-31

Partnership

Take a look of project's partnership.

#	participants	country	role	EC contrib. [€]
1	EIDGENOESSISCHE TECHNISCHE HOCHSCHULE ZUERICH EIDGENOESSISCHE TECHNISCHE HOCHSCHULE ZUERICH Organization address address: Raemistrasse 101 city: ZUERICH postcode: 8092 website: https://www.ethz.ch/de.html contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	CH (ZUERICH)	coordinator	1˙223˙000.00
2	ECOLE SUPERIEURE DE PHYSIQUE ET DECHIMIE INDUSTRIELLES DE LA VILLE DEPARIS ECOLE SUPERIEURE DE PHYSIQUE ET DECHIMIE INDUSTRIELLES DE LA VILLE DEPARIS Organization address address: RUE VAUQUELIN 10 city: PARIS postcode: 75231 website: www.espci-paristech.fr contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	FR (PARIS)	participant	277˙000.00

Map

Project objective

Antibodies play an important role ensuring successful protection after vaccination. Upon injection, antigen-binding antibodies are generated to prime the host’s immune system for future encounters with the threat. These responses are highly heterogeneous, with each cell contributing with a single antibody variant to the complexity. Each antibody variant furthermore can recognize a different antigen/epitope with varying specificity and affinity. The immunological function induced is related to those parameters.

Depending on the nature of the threat, required protective functional antibodies vary. Therefore, also each vaccination against those threads needs to trigger a specific functional antibody repertoire. Presently, induced functional antibody repertoires have not yet been studied sufficiently, mostly due to the lack of technologies that enable analysing these repertoires with high enough throughput and resolution. Consequently, the mechanisms behind the evolution of these functional repertoires, and the influence of vaccination on these repertoires remain poorly understood.

An innovative technology combined with a methodical approach to vaccinations will enable the FuncMab research team to generate data sets needed for the understanding of immunological processes that result in different functional antibody repertoires. Herein, antibodies are analysed on the individual cell level in high-throughput using specific bioassays that target various antibody functions and their biophysical parameters, generating high-resolution data. These functional repertoires are followed over time and evolutionary changes can be linked to introduced vaccine variations, allowing a quantitative approach to study the changes within the repertoires. These in-depth data sets will not only allow understanding interactions between vaccine components and their generated immune responses, but also propels this project to the forefront of creating a new generation of successful vaccines

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The information about "FUNCMAB" are provided by the European Opendata Portal: CORDIS opendata.