ArtHep SIGNED
Hepatocytes-Like Microreactors for Liver Tissue Engineering
Total Cost €
0EC-Contrib. €
0Partnership
0Views
0ArtHep project word cloud
Explore the words cloud of the ArtHep project. It provides you a very rough idea of what is the project "ArtHep" about.
Project "ArtHep" data sheet
The following table provides information about the project.
| Coordinator |
AARHUS UNIVERSITET
Organization address contact info |
| Coordinator Country | Denmark [DK] |
| Total cost | 1˙992˙289 € |
| EC max contribution | 1˙992˙289 € (100%) |
| Programme |
1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC)) |
| Code Call | ERC-2018-COG |
| Funding Scheme | ERC-COG |
| Starting year | 2019 |
| Duration (year-month-day) | from 2019-05-01 to 2024-04-30 |
Partnership
Take a look of project's partnership.
| # | ||||
|---|---|---|---|---|
| 1 | AARHUS UNIVERSITET | DK (AARHUS C) | coordinator | 1˙992˙289.00 |
Map
Project objective
The global epidemics of obesity and diabetes type 2 lead to higher abundancy of medical conditions like non-alcoholic fatty liver disease causing an increase in liver failure and demand for liver transplants. The shortage of donor organs and the insufficient success in tissue engineering to ex vivo grow complex organs like the liver is a global medical challenge.
ArtHep targets the assembly of hepatic-like tissue, consisting of biological and synthetic entities, mimicking the core structure elements and key functions of the liver. ArtHep comprises an entirely new concept in liver regeneration with multi-angled core impact: i) cell mimics are expected to reduce the pressure to obtain donor cells, ii) the integrated biocatalytic subunits are destined to take over tasks of the damaged liver slowing down the progress of liver damage, and iii) the matching micro-environment in the bioprinted tissue is anticipated to facilitate the connection between the transplant and the liver.
Success criteria of ArtHep include engineering enzyme-mimics, which can perform core biocatalytic conversions similar to the liver, the assembly of biocatalytic active subunits and their encapsulation in cell-like carriers (microreactors), which have mechanical properties that match the liver tissue and that have a camouflaging coating to mimic the surface cues of liver tissue-relevant cells. Finally, matured bioprinted liver-lobules consisting of microreactors and live cells need to connect to liver tissue when transplanted into rats.
I am convinced that the ground-breaking research in ArtHep will contribute to the excellence of science in Europe while providing the game-changing foundation to counteract the ever increasing donor liver shortage. Further, consolidating my scientific efforts and moving them forward into unexplored dimensions in biomimicry for medical purposes, is a unique opportunity to advance my career.
Are you the coordinator (or a participant) of this project? Plaese send me more information about the "ARTHEP" project.
For instance: the website url (it has not provided by EU-opendata yet), the logo, a more detailed description of the project (in plain text as a rtf file or a word file), some pictures (as picture files, not embedded into any word file), twitter account, linkedin page, etc.
Send me an email (fabio@fabiodisconzi.com) and I put them in your project's page as son as possible.
Thanks. And then put a link of this page into your project's website.
The information about "ARTHEP" are provided by the European Opendata Portal: CORDIS opendata.
More projects from the same programme (H2020-EU.1.1.)
ORGANITRA (2019)
Transport of phosphorylated compounds across lipid bilayers by supramolecular receptors
Read More