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ReCoDE SIGNED

Reshaping cortical circuits to decrease binge eating

Total Cost €

0

EC-Contrib. €

0

Partnership

0

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 ReCoDE project word cloud

Explore the words cloud of the ReCoDE project. It provides you a very rough idea of what is the project "ReCoDE" about.

diseases    strategy    circuits    pathology    synapses    limit    therapeutic    protocols    optogenetics    disruptions    unclear    restored    cutting    obesity    ravenous    vivo    food    hindered    network    prefrontal    functionally    unravel    predict    maintains    concurrent    lateral    society    edge    engage    normalizing    patients    critical    functional    urgently    lha    orchestrating    pfc    region    dysfunction    prominently    reorganization    humans    plasticity    hypothalamus    rebalances    tracing    pathologies    neurobiology    function    unknown    mouse    recordings    engenders    electrophysiology    treatments    neural    cortical    output    successful    photometric    stress    intake    normalized    hypotheses    feeding    regulation    link    calcium    sites    limits    optogenetic    cortex    cope    binge    models    moving    mice    innervates    rodents    combining    multiple    gap    altered    combine    eating    circuit    threefold    alters    brain    gain    little    disorders    fiber    circuitry   

Project "ReCoDE" data sheet

The following table provides information about the project.

Coordinator
UNIVERSITAIR MEDISCH CENTRUM UTRECHT 

Organization address
address: HEIDELBERGLAAN 100
city: UTRECHT
postcode: 3584 CX
website: www.umcutrecht.nl

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Netherlands [NL]
 Total cost 1˙499˙966 €
 EC max contribution 1˙499˙966 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2018-STG
 Funding Scheme ERC-STG
 Starting year 2019
 Duration (year-month-day) from 2019-07-01   to  2024-06-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNIVERSITAIR MEDISCH CENTRUM UTRECHT NL (UTRECHT) coordinator 1˙499˙966.00

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 Project objective

Obesity and eating disorders are critical problems in society. Many patients with these brain diseases cope with stress by ravenous food intake (binge eating), which engenders new stress and maintains the pathology. Evidence-based treatments for this are urgently needed, but their implementation is hindered by a knowledge gap on: (i) which stress-driven neural disruptions cause binge eating, and (ii) whether these neural circuit changes can be normalized for therapeutic gain. Studies in humans and rodents link binge eating to dysfunction of the prefrontal cortex (PFC), a brain region orchestrating the stress response. However, it is unknown how effects of stress on PFC output cause binge eating. The PFC prominently innervates the lateral hypothalamus (LHA), a region with a crucial role in managing food intake, yet little is known about the function of PFC regulation of the LHA. I predict that stress-induced binge eating requires a functional reorganization of prefrontal cortical control over lateral hypothalamus feeding circuits, and that this control can be restored to limit binge eating.

I propose a cutting-edge threefold strategy to address these hypotheses in mouse models: 1. I will unravel the make-up of PFC-LHA circuitry, combining electrophysiology, optogenetics and neural tracing. I will assess how stress functionally alters this complex network.

2. I will determine the concurrent activity at multiple sites within PFC-LHA circuitry as mice engage in stress-driven binge eating, using fiber photometric calcium recordings.

3. I will assess if normalizing stress-altered PFC-LHA synapses rebalances this circuitry in vivo and limits binge eating. For this I will combine optogenetic plasticity protocols, with fiber photometric measurements in freely moving mice.

Overall, this challenging project aims to unravel the unclear neurobiology of stress-induced binge eating. If successful, this would provide a key advance in understanding binge eating pathologies.

Are you the coordinator (or a participant) of this project? Plaese send me more information about the "RECODE" project.

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The information about "RECODE" are provided by the European Opendata Portal: CORDIS opendata.

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