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CVD_CysSSSCys
Investigating the Therapeutic Potential of Persulfides: Implications of their Roles in Cardiovascular Disease
Total Cost €
0EC-Contrib. €
0Partnership
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0CVD_CysSSSCys project word cloud
Explore the words cloud of the CVD_CysSSSCys project. It provides you a very rough idea of what is the project "CVD_CysSSSCys" about.
prevent
symptoms
search
discovered
cardiovascular
worldwide
ssh
though
stability
treat
human
altogether
display
first
difficult
hypothesize
releases
electrophiles
despite
irrelevant
tissue
trisulfide
epidemic
donor
mechanisms
critical
cysteine
donors
prevention
treatment
models
displaying
global
stable
molecule
animal
persulfides
compounds
ideal
mostly
potentially
serves
biologically
lack
cys
fatal
devastating
reliant
disease
cellular
cvd
sss
nature
lastly
diseases
prove
variety
cure
efforts
therapeutic
afford
discovery
etiology
examine
aiding
species
cells
unfortunately
potent
markers
sulfur
too
reactive
therapeutics
scavengers
intracellular
persulfide
healthcare
oxidants
Project "CVD_CysSSSCys" data sheet
The following table provides information about the project.
| Coordinator |
QUEEN MARY UNIVERSITY OF LONDON
Organization address contact info |
| Coordinator Country | United Kingdom [UK] |
| Total cost | 224˙933 € |
| EC max contribution | 224˙933 € (100%) |
| Programme |
1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility) |
| Code Call | H2020-MSCA-IF-2018 |
| Funding Scheme | MSCA-IF-EF-ST |
| Starting year | 2019 |
| Duration (year-month-day) | from 2019-04-01 to 2021-03-31 |
Partnership
Take a look of project's partnership.
| # | ||||
|---|---|---|---|---|
| 1 | QUEEN MARY UNIVERSITY OF LONDON | UK (LONDON) | coordinator | 224˙933.00 |
Map
Project objective
Cardiovascular disease (CVD) is the number one most fatal disease worldwide and despite many efforts, there is still no current treatment. Thus, the discovery of novel therapeutics to treat CVD is critical. Persulfides are biologically-relevant sulfur species that display much therapeutic potential in a variety of human disease, including CVD. Importantly, persulfides are potent scavengers of many disease-associated oxidants and electrophiles, making persulfides potentially relevant in the etiology of such diseases. Unfortunately, the reactive nature of persulfides makes their study difficult and reliant on the use of donor compounds. As a result, various persulfide donors have been developed, though these too often lack stability and are mostly biologically-irrelevant. Therefore, to address these issues, I discovered a novel persulfide donor, cysteine trisulfide (Cys-SSS-Cys). Cys-SSS-Cys is a stable biologically relevant molecule that upon reduction, releases cysteine persulfide (Cys-SSH), which is also a biologically relevant species. Thus, I hypothesize Cys-SSS-Cys is an ideal persulfide donor to study the therapeutic properties of persulfides, and that Cys-SSS-Cys will prove to be a novel therapeutic for the prevention and/or treatment of CVD. To assess this, I will examine effects of Cys-SSS-Cys on cellular, tissue and whole animal models displaying symptoms of CVD. First, I will identify mechanisms for cellular uptake and intracellular reduction of Cys-SSS-Cys to afford Cys-SSH. Next, I will measure the ability for Cys-SSS-Cys to prevent/treat markers associated with CVD in cells and tissue. Lastly, I will evaluate whether Cys-SSS-Cys serves as a therapeutic for CVD in whole animal models. Altogether, this research aims to identify Cys-SSS-Cys as a novel therapeutic to treat CVD; aiding in the advancement of global healthcare and the search for a cure to a devastating worldwide epidemic.
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