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PD-MitoQUANT SIGNED

PD-MitoQUANT – A quantitative approach towards the characterisation of mitochondrial dysfunction in Parkinson's disease

Total Cost €

EC-Contrib. €

Partnership

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PD-MitoQUANT project word cloud

Explore the words cloud of the PD-MitoQUANT project. It provides you a very rough idea of what is the project "PD-MitoQUANT" about.

proteotoxicity disciplinary function provision er progress genexplain cnr continuing neuron expertise innovative neurons pd dzne sustainable validate investigations clinical ucb biochemistry thorough dysfunction ucl teva assembled animal quantitative di puk signaling systematic disease structural silico lacking biomarkers broccoli syn hunot computationally effect alpha rumc vivo upr proteostasis tissue mimetas icm melki panel sme rcsi excellence efpia progressed human abramov implicated prehn teams ageing biology perform platform ipsc characterisation initiate parkinson lundbeck models description expert biobank corti relation toxicity academic unprecedented monte stress mitoquant mitochondrial koopmann culture leverages cnrs primary therapeutic vitro representing

Project "PD-MitoQUANT" data sheet

The following table provides information about the project.

Coordinator	ROYAL COLLEGE OF SURGEONS IN IRELAND Organization address address: Saint Stephen's Green 123 city: DUBLIN postcode: 2 website: www.rcsi.ie contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.
Coordinator Country	Ireland [IE]
Total cost	6˙882˙315 €
EC max contribution	4˙497˙935 € (65%)
Programme	1. H2020-EU.3.1.7. (Innovative Medicines Initiative 2 (IMI2))
Code Call	H2020-JTI-IMI2-2017-13-two-stage
Funding Scheme	IMI2-RIA
Starting year	2019
Duration (year-month-day)	from 2019-02-01 to 2022-01-31

Partnership

Take a look of project's partnership.

#	participants	country	role	EC contrib. [€]
1	ROYAL COLLEGE OF SURGEONS IN IRELAND ROYAL COLLEGE OF SURGEONS IN IRELAND Organization address address: Saint Stephen's Green 123 city: DUBLIN postcode: 2 website: www.rcsi.ie contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	IE (DUBLIN)	coordinator	1˙095˙123.00
2	INSTITUT DU CERVEAU ET DE LA MOELLE EPINIERE INSTITUT DU CERVEAU ET DE LA MOELLE EPINIERE Organization address address: BOULEVARD DE L'HOPITAL 47 city: PARIS postcode: 75013 website: http://icm-institute.org/ contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	FR (PARIS)	participant	855˙375.00
3	CONSIGLIO NAZIONALE DELLE RICERCHE CONSIGLIO NAZIONALE DELLE RICERCHE Organization address address: PIAZZALE ALDO MORO 7 city: ROMA postcode: 185 website: www.cnr.it contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	IT (ROMA)	participant	544˙635.00
4	DEUTSCHES ZENTRUM FUR NEURODEGENERATIVE ERKRANKUNGEN EV DEUTSCHES ZENTRUM FUR NEURODEGENERATIVE ERKRANKUNGEN EV Organization address address: SIGMUND FREUD STRASSE 27 city: BONN postcode: 53127 website: www.dzne.de contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	DE (BONN)	participant	541˙118.00
5	STICHTING KATHOLIEKE UNIVERSITEIT STICHTING KATHOLIEKE UNIVERSITEIT Organization address address: GEERT GROOTEPLEIN NOORD 9 city: NIJMEGEN postcode: 6525 EZ website: www.radboudumc.nl contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	NL (NIJMEGEN)	participant	403˙885.00
6	UNIVERSITY COLLEGE LONDON UNIVERSITY COLLEGE LONDON Organization address address: GOWER STREET city: LONDON postcode: WC1E 6BT website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	UK (LONDON)	participant	360˙587.00
7	MIMETAS BV MIMETAS BV Organization address address: JH Oortweg 19 city: Leiden postcode: 2333CH website: www.mimetas.com contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	NL (Leiden)	participant	250˙835.00
8	CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS Organization address address: RUE MICHEL ANGE 3 city: PARIS postcode: 75794 website: www.cnrs.fr contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	FR (PARIS)	participant	160˙000.00
9	GENEXPLAIN GMBH GENEXPLAIN GMBH Organization address address: AM EXER 19 B city: WOLFENBUTTEL postcode: 38302 website: www.genexplain.com contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	DE (WOLFENBUTTEL)	participant	148˙875.00
10	PINTAIL LTD PINTAIL LTD Organization address address: SPRINGHILL AVENUE 77 city: Blackrock postcode: A94 K542 website: www.pintail.eu contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	IE (Blackrock)	participant	137˙500.00
11	H. LUNDBECK AS H. LUNDBECK AS Organization address address: OTTILIAVEJ 7-9 city: VALBY postcode: 2500 website: www.lundbeck.com contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	DK (VALBY)	participant	0.00
12	PARKINSON'S DISEASE SOCIETY OF THEUNITED KINGDOM LBG PARKINSON'S DISEASE SOCIETY OF THEUNITED KINGDOM LBG Organization address address: VAUXHALL BRIDGE RAOD 215 city: LONDON postcode: SW1V 1EJ website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	UK (LONDON)	participant	0.00
13	TEVA PHARMACEUTICAL INDUSTRIES LIMITED TEVA PHARMACEUTICAL INDUSTRIES LIMITED Organization address address: 5 BASEL ST city: PETACH TIVKA postcode: 49131 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	IL (PETACH TIVKA)	participant	0.00
14	UCB BIOPHARMA SRL UCB BIOPHARMA SRL Organization address address: ALLEE DE LA RECHERCHE 60 city: BRUXELLES postcode: 1070 website: www.ucb.com contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	BE (BRUXELLES)	participant	0.00

Map

Project objective

Mitochondrial dysfunction is implicated in Parkinson’s Disease (PD), but detailed understanding of the cause and effect in αSyn toxicity is lacking. Through provision of quantitative and systematic characterisation of mitochondrial dysfunction, PD-MitoQUANT will provide unprecedented understanding of the role of mitochondrial dysfunction in PD, identify and validate novel disease biomarkers, and propose innovative therapeutic targets that can be further progressed by the EFPIA partners. The consortium leverages multi-disciplinary expertise in the fields of αSyn biochemistry, iPSC-derived PD models, mitochondrial function and structural analysis, proteotoxicity, ER stress and UPR signaling, systems biology of mitochondrial function, and in vivo animal models. A key focus will be quantitative description and integrated analysis of mitochondrial function and its relation to proteotoxicity; representing a key panel of consortium partners Prehn [RCSI], Abramov [UCL], Corti [ICM] and Koopmann [RUMC] who also have assembled long–standing expertise in primary neuron culture, iPSC-derived neurons, PD in vivo models, proteostasis and ageing studies. These investigations will be supported by expert teams in iPSC-derived in vitro PD models and in vivo PD models from the academic partners (Hunot [ICM], Melki [CNRS], Di Monte [DZNE], Broccoli [CNR], SME [Mimetas] and EFPIA partners [Teva], [Lundbeck] and [UCB]. Through integrated in vitro, in silico and in vivo approaches, and supported computationally by SME [GENEXPLAIN], PD-MitoQUANT will perform thorough and unprecedented investigations of mitochondrial dysfunction. Finally, the consortium will initiate a European research platform of excellence investigating mitochondrial dysfunction in PD continuing beyond the project, further supported by [PUK]’s PD human tissue biobank. This will provide long-term and sustainable progress in the understanding of mitochondrial dysfunction in PD and towards clinical application.

Publications

List of publications.
year	authors and title	journal	last update
2020	Josquin Courte, Luc Bousset, Ysander Von Boxberg, Catherine Villard, Ronald Melki, Jean-Michel Peyrin The expression level of alpha-synuclein in different neuronal populations is the primary determinant of its prion-like seeding published pages: , ISSN: 2045-2322, DOI: 10.1038/s41598-020-61757-x	Scientific Reports 10/1	2020-04-01
2020	Amulya Nidhi Shrivastava, Luc Bousset, Marianne Renner, Virginie Redeker, Jimmy Savistchenko, Antoine Triller, Ronald Melki Differential Membrane Binding and Seeding of Distinct Î±-Synuclein Fibrillar Polymorphs published pages: , ISSN: 0006-3495, DOI: 10.1016/j.bpj.2020.01.022	Biophysical Journal 27 January 2020	2020-03-23
2019	Nolwen L. Rey, Luc Bousset, Sonia George, Zachary Madaj, Lindsay Meyerdirk, Emily Schulz, Jennifer A. Steiner, Ronald Melki, Patrik Brundin Î±-Synuclein conformational strains spread, seed and target neuronal cells differentially after injection into the olfactory bulb published pages: 1-18, ISSN: 2051-5960, DOI: 10.1186/s40478-019-0859-3	Acta Neuropathologica Communications 7/1	2020-03-19
2019	M. Jacoupy, E. Hamon-Keromen, A. Ordureau, Z. Erpapazoglou, F. Coge, J.-C. Corvol, O. Nosjean, C. Mannoury la Cour, M. J. Millan, J. A. Boutin, J. W. Harper, A. Brice, D. Guedin, C. A. Gautier, O. Corti The PINK1 kinase-driven ubiquitin ligase Parkin promotes mitochondrial protein import through the presequence pathway in living cells published pages: 1-15, ISSN: 2045-2322, DOI: 10.1038/s41598-019-47352-9	Scientific Reports 9/1	2020-03-19
2019	Parvez Alam, Luc Bousset, Ronald Melki, Daniel E. Otzen Î±â€synuclein oligomers and fibrils: a spectrum of species, a spectrum of toxicities published pages: , ISSN: 0022-3042, DOI: 10.1111/jnc.14808	Journal of Neurochemistry	2020-03-19

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