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EpimiRTherapy SIGNED

Using human tissue to translate microRNA-based therapies for epilepsy

Total Cost €

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EC-Contrib. €

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Partnership

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 EpimiRTherapy project word cloud

Explore the words cloud of the EpimiRTherapy project. It provides you a very rough idea of what is the project "EpimiRTherapy" about.

elucidate    modifying    micrornas    tissue    slices    gap    meet    secondment    single    antisense    treat    resolution    host    regulate    anti    serve    neuron    training    limited    urgent    brain    disease    humans    interdisciplinary    protein    techniques    complemented    molecules    seizure    ant    acquired    molecular    professional    network    never    unmet    clinical    cell    independence    rcsi    maturity    rnas    electrophysiology    position    resected    antagomirs    whilst    core    first    treatment    lobectomies    transfer    microrna    cutting    surgically    edge    fills    fellowship    time    biophysical    certain    launchpad    treatments    coding    transcriptional    knockdown    landscapes    translational    myself    reaching    collaborators    134    levels    icl    antagomir    imaging    expertise    combination    human    temporal    epimirtherapy    neurological    therapy    rodents    lab    intersectoral    mechanism    tested    epilepsy    collaborations   

Project "EpimiRTherapy" data sheet

The following table provides information about the project.

Coordinator
ROYAL COLLEGE OF SURGEONS IN IRELAND 

Organization address
address: Saint Stephen's Green 123
city: DUBLIN
postcode: 2
website: www.rcsi.ie

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Ireland [IE]
 Total cost 184˙590 €
 EC max contribution 184˙590 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2018
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2019
 Duration (year-month-day) from 2019-12-01   to  2021-11-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    ROYAL COLLEGE OF SURGEONS IN IRELAND IE (DUBLIN) coordinator 184˙590.00

Map

 Project objective

The overall research aim of EpimiRTherapy is to elucidate the mechanism of a novel disease-modifying therapy for epilepsy at single cell resolution in the human brain. MicroRNAs are short non-coding RNAs which regulate protein levels in the brain. Certain microRNAs are strongly associated with epilepsy and their knockdown, using antisense molecules called ‘antagomirs’, has anti-seizure effects in rodents. Antagomir targeting microRNA-134 (ant-134) is a particularly promising disease-modifying treatment for epilepsy, which could meet an urgent clinical need. However, antagomirs to treat neurological disease have never been tested in humans due to limited translational evidence. EpimiRTherapy, for the first time, fills this gap: I will use state-of-the-art techniques to produce human brain slices from tissue surgically resected during temporal lobectomies for epilepsy. I will use a combination of molecular techniques (acquired at the host lab in RCSI and through secondment to ICL) and electrophysiology, my core expertise, to determine the impact of ant-134 on the biophysical and transcriptional landscapes of human tissue and a network and single neuron level. This will be complemented with cutting edge systems modelling and imaging techniques acquired through collaborations. This fellowship, through advanced interdisciplinary and intersectoral training, will serve as a launchpad for reaching a position of professional independence and maturity, whilst at the same time facilitating a transfer of knowledge between myself, the host and the collaborators, by bringing cutting edge electrophysiology and human tissue processing techniques to RCSI and addressing an urgent and unmet clinical need for novel epilepsy treatments.

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The information about "EPIMIRTHERAPY" are provided by the European Opendata Portal: CORDIS opendata.

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