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SMARTBOX SIGNED

Selective Modifications of ARomatics through Biocatalytic Oxidations

Total Cost €

EC-Contrib. €

Partnership

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SMARTBOX project word cloud

Explore the words cloud of the SMARTBOX project. It provides you a very rough idea of what is the project "SMARTBOX" about.

lignin oxidative improves complete enzyme industries fractionation similarity computational experimental implementing environmental combination polycarbonates adopting intervention biorefineries economic human conversion rcf building time significantly algorithms automatically oxidation yields variants hmf bio platform learning catalytic minimal fold block aromatics caused biocatalysis theoretical blocks mainly engineering innovations intermediates biomass vanillin carbon predictability sustainability near train selectively breakthrough machine enzymes evolution screen fdca reductive structural chemical footprint smartbox directed yielding smart monomers ing biobased decrease relying screening although sota

Project "SMARTBOX" data sheet

The following table provides information about the project.

Coordinator	BIO BASE EUROPE PILOT PLANT VZW Organization address address: RODENHUIZEKAAI 1 city: DESTELDONK GENT postcode: 9042 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.
Coordinator Country	Belgium [BE]
Total cost	4˙511˙562 €
EC max contribution	3˙924˙163 € (87%)
Programme	1. H2020-EU.2.1.4. (INDUSTRIAL LEADERSHIP - Leadership in enabling and industrial technologies – Biotechnology) 2. H2020-EU.3.2. (SOCIETAL CHALLENGES - Food security, sustainable agriculture and forestry, marine, maritime and inland water research, and the bioeconomy)
Code Call	H2020-BBI-JTI-2018
Funding Scheme	BBI-RIA
Starting year	2019
Duration (year-month-day)	from 2019-05-01 to 2023-04-30

Partnership

Take a look of project's partnership.

#	participants	country	role	EC contrib. [€]
1	BIO BASE EUROPE PILOT PLANT VZW BIO BASE EUROPE PILOT PLANT VZW Organization address address: RODENHUIZEKAAI 1 city: DESTELDONK GENT postcode: 9042 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	BE (DESTELDONK GENT)	coordinator	885˙375.00
2	KATHOLIEKE UNIVERSITEIT LEUVEN KATHOLIEKE UNIVERSITEIT LEUVEN Organization address address: OUDE MARKT 13 city: LEUVEN postcode: 3000 website: www.kuleuven.be contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	BE (LEUVEN)	participant	807˙750.00
3	RIJKSUNIVERSITEIT GRONINGEN RIJKSUNIVERSITEIT GRONINGEN Organization address address: Broerstraat 5 city: GRONINGEN postcode: 9712CP website: www.rug.nl contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	NL (GRONINGEN)	participant	418˙867.00
4	AVA BIOCHEM BSL AG AVA BIOCHEM BSL AG Organization address address: ROTHAUSSTRASSE 61 city: MUTTENZ postcode: 4132 website: www.ava-biochem.com contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	CH (MUTTENZ)	participant	391˙875.00
5	UNIVERSIDADE NOVA DE LISBOA UNIVERSIDADE NOVA DE LISBOA Organization address address: CAMPUS DE CAMPOLIDE city: LISBOA postcode: 1099 085 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	PT (LISBOA)	participant	325˙521.00
6	QUANTIS QUANTIS Organization address address: PARC SCIENTIFIQUE EPFL PSE D city: ECUBLENS VD postcode: 1024 website: www.quantis-intl.com contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	CH (ECUBLENS VD)	participant	322˙500.00
7	UNIVERSITA DEGLI STUDI DI PAVIA UNIVERSITA DEGLI STUDI DI PAVIA Organization address address: STRADA NUOVA 65 city: PAVIA postcode: 27100 website: www.unipv.it contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	IT (PAVIA)	participant	303˙750.00
8	B4PLASTICS B4PLASTICS Organization address address: PAUL LAMBERTLAAN 88 city: MAASMECHELEN postcode: 3630 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	BE (MAASMECHELEN)	participant	262˙400.00
9	ZYMVOL BIOMODELING SL ZYMVOL BIOMODELING SL Organization address address: PASEO DE RONDA 78 1 1 city: LLEIDA postcode: 25006 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	ES (LLEIDA)	participant	206˙125.00
10	BORREGAARD AS BORREGAARD AS Organization address address: HJALMAR WESSELS VEI 6 city: SARPSBORG postcode: 1721 website: www.borregaard.com contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	NO (SARPSBORG)	participant	0.00
11	COVESTRO DEUTSCHLAND AG COVESTRO DEUTSCHLAND AG Organization address address: KAISER WILHELM ALLEE 60 city: LEVERKUSEN postcode: 51373 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	DE (LEVERKUSEN)	participant	0.00

Map

Project objective

Although they have the potential to improve the economic and environmental sustainability of biorefineries, oxidative enzymes have not experienced a complete breakthrough yet in the biobased industries. This is mainly caused by the high cost and long time associated with traditional enzyme engineering methods such as directed evolution. SMARTBOX will develop an advanced computational engineering platform specifically for oxidative enzymes, which can automatically screen for improved enzyme variants with minimal human intervention. This is achieved by implementing several innovations into current computational screening methods, most importantly machine learning, which allows to train the algorithms with experimental results. As this significantly improves computational predictability, the time and costs associated with oxidative enzyme engineering will be reduced 10-fold compared to state-of-the-art (SOTA) directed evolution methods.

Relying on the advanced engineering platform, SMARTBOX will develop the one-enzyme conversion of HMF into FDCA and intermediates, and the one-enzyme conversion of lignin monomers into a potential biobased building block for polycarbonates and vanillin. By adopting a 1-enzyme FDCA production process, the associated production costs and carbon footprint are expected to decrease significantly compared to SOTA chemical oxidation methods. The unique feature of SMARTBOX is that reductive catalytic fractionation (RCF) will be used to selectively produce specific lignin monomers from biomass in near theoretical yields. The structural similarity of the resulting monomers with the SMARTBOX building blocks allows the development of high-yielding processes with only one enzyme. Due to the smart combination between oxidative biocatalysis and RCF, the production of bio-aromatics will proceed with higher yields than the state of the art.

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The information about "SMARTBOX" are provided by the European Opendata Portal: CORDIS opendata.