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ALCO-ADO SIGNED

Unveiling the alcohol-dependent alterations in local dendritic translation of mRNAs in the prefrontal cortex during adolescence

Total Cost €

0

EC-Contrib. €

0

Partnership

0

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 ALCO-ADO project word cloud

Explore the words cloud of the ALCO-ADO project. It provides you a very rough idea of what is the project "ALCO-ADO" about.

modifies    alcohol    addiction    executive    shown    biochemistry    maladaptive    altered    mice    during    immaturity    excessive    frontal    undergoes    synaptic    involvement    usurps    mainly    molecular    psychological    glutamatergic    males    proteins    functions    pfc    composition    imaging    vulnerability    adolescence    intense    adolescents    brain    mesocorticolimbic    deleterious    interneurons    heightened    behaviors    regions    tests    differences    gabaergic    mechanisms    connections    dependent    defective    function    poorly    defects    multidisciplinary    lasting    neuronal    drugs    learning    sites    eif2    precise    form    prefrontal    memory    plasticity    alpha    alterations    impairs    strength    translatome    modulating    male    female    differential    modulates    impulsivity    adolescent    uncover    neurons    consumption    drug    regulators    analyze    females    mtorc1    translation    profoundly    cortex    local    maturation    sensibility    implicated    combining    underlying    mrnas    modifications    neurocognitive    populations    behavioral    electrophysiology   

Project "ALCO-ADO" data sheet

The following table provides information about the project.

Coordinator		 UNIVERSITE DE LIEGE 

Organization address
address: PLACE DU 20 AOUT 7
city: LIEGE
postcode: 4000
website: www.ulg.ac.be

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.
 Coordinator Country Belgium [BE]
 Total cost 178˙320 €
 EC max contribution 178˙320 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2018
 Funding Scheme MSCA-IF-EF-RI
 Starting year 2019
 Duration (year-month-day) from 2019-04-01   to  2021-03-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNIVERSITE DE LIEGE BE (LIEGE) coordinator 178˙320.00

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 Project objective

During adolescence, the brain undergoes intense maturation, particularly in the frontal areas. The prefrontal cortex (PFC) is implicated in executive functions, and its immaturity in adolescents is associated with increased impulsivity and heightened vulnerability to deleterious effects of drugs. Alcohol is the most consumed drug among adolescents, and its excessive consumption profoundly impairs PFC function, leading to long-lasting defective behaviors, psychological problems and neurocognitive defects. However, the precise mechanisms underlying alcohol-induced alterations in PFC maturation remain poorly understood. Alcohol addiction is considered being a maladaptive form of learning and memory, as alcohol usurps the molecular mechanisms underlying those processes, such as long-lasting synaptic plasticity. Long-lasting changes in the strength of synaptic connections mainly depend on the local translation of mRNAs at synaptic sites. It has been shown that alcohol modifies synaptic proteins composition by modulating the activity of key translation regulators, such as mTORC1 and eIF2α, in brain regions associated with the mesocorticolimbic pathway. Here, we propose to analyze the alcohol-dependent modifications of the synaptic translatome of specific neuronal populations (glutamatergic neurons and GABAergic interneurons) in the PFC of adolescent male and female mice, by using a multidisciplinary approach combining biochemistry, imaging, electrophysiology and behavioral tests. This project aims to uncover how alcohol modulates local translation of synaptic proteins in the PFC during adolescence, to identify the targeted synaptic mRNAs and analyze their involvement in altered synaptic plasticity underlying alcohol-dependent defective behaviors. In addition, this project aims at identifying the differential sensibility to alcohol’s effects between males and females as well as the differences in behavioral consequences.

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