#	Pagina
attuale pagina	/open-h2020/projects/224674/index.html

Opendata, web and dolomites

AntiHelix SIGNED

DNA helicases in genome maintenance: from molecular and cellular mechanisms to specific inhibitors as potential drugs

Total Cost €

0

EC-Contrib. €

0

Partnership

0

Views

0

AntiHelix project word cloud

Explore the words cloud of the AntiHelix project. It provides you a very rough idea of what is the project "AntiHelix" about.

transport science competitive tested relationships translation skills biophysical of integrity eukaryotic companies oncology remodel techniques cancer proteins variety scientists anti drugs inhibitors openness structure physiological found antiviral obtain atp archaea insights discovery implicated sectors single energy educate biology full molecule coupled clinical culture rna picture young academic transparency play human cancers reaction laboratories generation market functions mechanism biochemical replication enzymes source viruses protein diseases recombination therapeutic function class dimension job dna genetic secondments discover molecular competence experts commitment chemistry cells date act structural drug repair private cellular reproducibility physics action expertise complementary stage bacteria helicases diverse training instrumentation mechanisms antibiotic accessibility separate revealed motor ubiquitous duplexes

Project "AntiHelix" data sheet

The following table provides information about the project.

Coordinator	CONSIGLIO NAZIONALE DELLE RICERCHE Organization address address: PIAZZALE ALDO MORO 7 city: ROMA postcode: 185 website: www.cnr.it contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.
Coordinator Country	Italy [IT]
Total cost	3˙508˙622 €
EC max contribution	3˙508˙622 € (100%)
Programme	1. H2020-EU.1.3.1. (Fostering new skills by means of excellent initial training of researchers)
Code Call	H2020-MSCA-ITN-2019
Funding Scheme	MSCA-ITN-ETN
Starting year	2019
Duration (year-month-day)	from 2019-10-01 to 2023-09-30

Partnership

Take a look of project's partnership.

#	participants	country	role	EC contrib. [€]
1	CONSIGLIO NAZIONALE DELLE RICERCHE CONSIGLIO NAZIONALE DELLE RICERCHE Organization address address: PIAZZALE ALDO MORO 7 city: ROMA postcode: 185 website: www.cnr.it contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	IT (ROMA)	coordinator	522˙999.00
2	KOBENHAVNS UNIVERSITET KOBENHAVNS UNIVERSITET Organization address address: NORREGADE 10 city: KOBENHAVN postcode: 1165 website: www.ku.dk contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	DK (KOBENHAVN)	participant	595˙044.00
3	ELETTRA - SINCROTRONE TRIESTE SCPA ELETTRA - SINCROTRONE TRIESTE SCPA Organization address address: SS 14 KM 163.5 city: BASOVIZZA TRIESTE postcode: 34149 website: www.elettra.trieste.it contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	IT (BASOVIZZA TRIESTE)	participant	522˙999.00
4	LEAD DISCOVERY CENTER GMBH LEAD DISCOVERY CENTER GMBH Organization address address: OTTO HAHN STRASSE 15 city: DORTMUND postcode: 44227 website: www.lead-disocvery.de contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	DE (DORTMUND)	participant	505˙576.00
5	THE UNIVERSITY OF SHEFFIELD THE UNIVERSITY OF SHEFFIELD Organization address address: FIRTH COURT WESTERN BANK city: SHEFFIELD postcode: S10 2TN website: www.shef.ac.uk contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	UK (SHEFFIELD)	participant	303˙172.00
6	EDELRIS SAS EDELRIS SAS Organization address address: AVENUE LACASSAGNE 115 city: LYON postcode: 69003 website: www.edelris.com contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	FR (LYON)	participant	274˙802.00
7	LUMICKS B.V. LUMICKS B.V. Organization address address: DE BOELELAAN 1081 city: AMSTERDAM postcode: 1081HV website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	NL (AMSTERDAM)	participant	265˙619.00
8	STICHTING VU STICHTING VU Organization address address: DE BOELELAAN 1105 city: AMSTERDAM postcode: 1081 HV website: www.vu.nl contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	NL (AMSTERDAM)	participant	265˙619.00
9	UNIVERSITAETSKLINIKUM ESSEN UNIVERSITAETSKLINIKUM ESSEN Organization address address: HUFELANDSTRASSE 55 city: ESSEN postcode: 45147 website: www.uk-essen.de/frauenklinik/ contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	DE (ESSEN)	participant	252˙788.00

Map

Project objective

Helicases are ubiquitous enzymes, found in viruses, Bacteria, Archaea and eukaryotic cells. They act as motor proteins to separate or remodel DNA or RNA duplexes, using ATP as an energy source. Helicases play a key role in a variety of cellular processes, including DNA replication/repair/recombination, as well as RNA translation and transport. They are emerging as an important class of targets for antiviral, antibiotic and anti-cancer drugs. To date, several genetic and biochemical studies have revealed the molecular and physiological functions of DNA helicases. Moreover, protein three-dimension structural studies coupled with single molecule biophysical approaches have provided insights into structure-function relationships and reaction mechanisms of some key DNA helicases. With a consortium including experts with complementary competence and expertise in Physics, Chemistry, Biology and Clinical Oncology, and a strong commitment of companies involved in drug discovery or in the development of state-of-the-art biophysical instrumentation, we aim to: 1. obtain a detailed picture of the mechanism of action and the physiological role of a number of DNA helicases that are implicated in human diseases; 2. discover specific inhibitors of those enzymes, which can then be tested as novel therapeutic drugs, especially for cancers; 3. address the need for training next generation scientists with complementary approaches and diverse techniques by secondments in different laboratories of the consortium; 4. promote a culture of collaboration between academic and private sectors and provide young scientists with the necessary experience and skills to exploit the full potential of research findings; 5. provide early stage researchers with greater opportunities to access an increasingly competitive job market; 6. promote the values of Open Science and educate young scientists on the importance of a culture of openness, transparency, accessibility, integrity and reproducibility.

Are you the coordinator (or a participant) of this project? Plaese send me more information about the "ANTIHELIX" project.

For instance: the website url (it has not provided by EU-opendata yet), the logo, a more detailed description of the project (in plain text as a rtf file or a word file), some pictures (as picture files, not embedded into any word file), twitter account, linkedin page, etc.

Send me an email (fabio@fabiodisconzi.com) and I put them in your project's page as son as possible.

Thanks. And then put a link of this page into your project's website.

The information about "ANTIHELIX" are provided by the European Opendata Portal: CORDIS opendata.

More projects from the same programme (H2020-EU.1.3.1.)

ARCH (2019)

AGE-RELATED CHANGES IN HEMATOPOIESIS

Read More

CHANGE (2019)

Cultural Heritage Analysis for New GEnerations

Read More

CLIPE (2020)

Creating Lively Interactive Populated Environments

Read More