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NEUcrest SIGNED

Training European Experts in Multiscale Studies of Neural Crest Development and Disorders: from Patient to Model Systems and Back again.

Total Cost €

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EC-Contrib. €

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Partnership

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 NEUcrest project word cloud

Explore the words cloud of the NEUcrest project. It provides you a very rough idea of what is the project "NEUcrest" about.

interdisciplinary    difficult    initiation    multidisciplinary    regulation    networking    derivatives    drug    melanoma    biological    neurocristopathy    computational    healthcare    strategies    neural    strategy    of    industry    genetic    understand    phenotyping    training    pleiotropic    embryonic    tumour    heart    neucrest    phenotypes    nc    animal    vivo    academia    networks    therapeutics    functional    genetics    reactivate    integrative    gene    broad    create    screening    synergistic    unified    translational    fundamentals    models    candidate    disease    neuroblastoma    events    optimise    tissue    discovery    public    neurocristopathies    improvements    cleftvpalate    esrs    cancers    clinicians    crest    interface    adrenals    genes    cellular    programs    diverse    molecular    mutations    caused    lineage    network    model    causative    human    gut    health    pharma    scientific    provides    framework    innovative    creative    clinical    patients    birth    scientists    back    environmental    syndromes    diseases    group    clinic    defects    takes   

Project "NEUcrest" data sheet

The following table provides information about the project.

Coordinator
INSTITUT CURIE 

Organization address
address: rue d'Ulm 26
city: PARIS
postcode: 75231
website: www.curie.fr

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country France [FR]
 Total cost 4˙156˙404 €
 EC max contribution 4˙156˙404 € (100%)
 Programme 1. H2020-EU.1.3.1. (Fostering new skills by means of excellent initial training of researchers)
 Code Call H2020-MSCA-ITN-2019
 Funding Scheme MSCA-ITN-ETN
 Starting year 2019
 Duration (year-month-day) from 2019-11-01   to  2023-10-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    INSTITUT CURIE FR (PARIS) coordinator 549˙604.00
2    UNIVERSITY OF EAST ANGLIA UK (NORWICH) participant 606˙345.00
3    NATIONAL UNIVERSITY OF IRELAND GALWAY IE (Galway) participant 549˙368.00
4    UNIVERSIDAD MIGUEL HERNANDEZ DE ELCHE ES (ELCHE) participant 501˙809.00
5    KING'S COLLEGE LONDON UK (LONDON) participant 303˙172.00
6    STEMCELL TECHNOLOGIES UK LTD UK (CAMBRIDGE) participant 303˙172.00
7    AZELEAD FR (MONTPELLIER) participant 274˙802.00
8    IMAGINE INSTITUT DES MALADIES GENETIQUES NECKER ENFANTS MALADES FONDATION FR (PARIS 15) participant 274˙802.00
9    ERASMUS UNIVERSITAIR MEDISCH CENTRUM ROTTERDAM NL (ROTTERDAM) participant 265˙619.00
10    MEDIZINISCHE UNIVERSITAET WIEN AT (WIEN) participant 264˙207.00
11    TEL AVIV UNIVERSITY IL (TEL AVIV) participant 263˙500.00

Map

 Project objective

Neurocristopathies caused by defects in the neural crest (NC) encompass a broad group of diseases from birth defects (cleftvpalate) to complex syndromes affecting systems such as heart, gut and adrenals. Because NC derivatives are diverse, mutations affecting this lineage can lead to pleiotropic phenotypes making it difficult to understand the causative events. Furthermore, NC-derived cancers, (e.g. melanoma and neuroblastoma) reactivate embryonic programs during tumour initiation. Our aim is to create a unique interdisciplinary network of scientists and clinicians partners from academia, healthcare, industry and the public sector with experience in gene discovery, genetics, functional studies and in vivo phenotyping aimed at training creative and innovative ESRs to study the overall genetic, molecular and environmental regulation of NC tissue in human health. To study each of complex aspects of NC and tumour formation, NEUcrest provides a synergistic framework for comprehensive analysis of candidate genes and biological processes, from patients to model systems to pharma and back to the clinic. With the aim to develop a unified strategy to identify new genetic and environmental factors that contribute to disease and to develop new drug targets for therapeutics, ESRs will address following scientific challenges: undertake novel gene discovery approaches; establish cellular/animal models of disease; establish integrative strategies for understanding neurocristopathies; optimise computational modelling of NC gene networks; establish translational strategies for drug screening in NC-related diseases; improve clinical management strategies of NC-disease and interface with patients and the public. Our training program takes into account training through research as well as multidisciplinary partnerships and networking opportunities. All together, this will improve our understanding of the fundamentals of neurocristopathy and contribute to improvements in healthcare.

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The information about "NEUCREST" are provided by the European Opendata Portal: CORDIS opendata.

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