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mARs SIGNED

mARs: Mobile DNA driven antibiotic resistance spreading: molecular strategies, control and evolution for broad distribution

Total Cost €

0

EC-Contrib. €

0

Partnership

0

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 mARs project word cloud

Explore the words cloud of the mARs project. It provides you a very rough idea of what is the project "mARs" about.

movies    humans    sparse    cells    antibiotic    data    strategies    gene    superbugs    interaction    resistance    drug    draw    environments    molecular    determinants    microbiology    functionally    broad    promotes    last    pathogens    regulation    biochemistry    genetics    quests    clinical    confer    situ    model    era    combining    underlying    view    movement    mechanistic    structural    bacteria    bacterial    communities    genes    spread    insights    mechanisms    intervention    dna    prevalence    evolution    significance    resort    transfer    carriers    promiscuous    reducing    meta    bioinformatic    rare    spreading    chart    machineries    health    dissect    virulent    genomic    structure    drive    occurs    preventive    care    reveal    multidrug    diversity    protein    unclear    resistant    vitro    microbial    transposons    hotspots    gut    biology    disciplines    implications    biochemical    drugs    mobile    ar    bridging    limited    bioinformatics    interplay    gained    annotated    elucidate    natural    functional    integrons   

Project "mARs" data sheet

The following table provides information about the project.

Coordinator
EUROPEAN MOLECULAR BIOLOGY LABORATORY 

Organization address
address: Meyerhofstrasse 1
city: HEIDELBERG
postcode: 69117
website: http://www.embl.de

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Germany [DE]
 Total cost 1˙999˙118 €
 EC max contribution 1˙999˙118 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2019-COG
 Funding Scheme ERC-COG
 Starting year 2021
 Duration (year-month-day) from 2021-01-01   to  2025-12-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    EUROPEAN MOLECULAR BIOLOGY LABORATORY DE (HEIDELBERG) coordinator 1˙999˙118.00

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 Project objective

Antibiotic resistance (AR) is spreading rapidly, leading to the development of highly virulent pathogens and multidrug-resistant ‘superbugs’, a major health concern of our era. Mobile DNA elements, transposons and integrons, effectively drive the spread of AR genes in microbial interaction hotspots, such as bacterial communities in humans and natural environments. Yet, our knowledge of their mechanisms remains very sparse. It is unclear how DNA movement occurs on the molecular level and how it is controlled in cells and communities; biochemical and structural data are rare and our view on their diversity and evolution is limited. Here I propose an integrated approach combining bioinformatics, genetics, microbiology, biochemistry, and structural biology to elucidate the mechanisms and diversity of mobile DNA driven resistance spreading. I want to (a) investigate the molecular mechanisms and regulation of AR gene movement in vitro, in model bacteria and in gut bacterial communities; (b) dissect the structure of the underlying molecular machineries to reveal how protein-DNA interplay promotes gene transfer; and (c) characterize the diversity, evolution and functional success of distinct molecular pathways. Mechanistic work will focus on selected mobile elements that confer resistance to last resort drugs and promiscuous gene carriers with high prevalence in health care. Bioinformatic quests will draw on recent (meta)genomic data to chart the clinical significance of molecular insights in situ. By bridging disciplines, I want to provide functionally annotated molecular movies of gene movement and explain how specific molecular strategies evolved to enable broad dissemination of resistance determinants. The insights gained in this research will provide in-depth knowledge on major AR transfer pathways and will have key implications for the development of novel intervention strategies and preventive measures aimed at reducing dissemination of drug resistance in bacteria.

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The information about "MARS" are provided by the European Opendata Portal: CORDIS opendata.

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