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FIDELIO SIGNED

Training network for research into bone Fragility In Diabetes in Europe – towards a personaLised medIcine apprOach

Total Cost €

0

EC-Contrib. €

0

Partnership

0

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 FIDELIO project word cloud

Explore the words cloud of the FIDELIO project. It provides you a very rough idea of what is the project "FIDELIO" about.

geneticists    transferable    mortality    techniques    edge    density    artificial    altered    engineers    training    burden    secondments    biologists    bone    fold    joint    area    subsequent    emerged    anabolic    trained    risk    webinars    companies    patient    succeed    normal    derive    morbidity    interdisciplinary    epidemiologists    cohorts    residential    mellitus    form    genetic    disease    technologies    suggests    stratification    imaging    diabetic    clinicians    fragility    hormones    courses    intelligence    fractures    preclinical    worldwide    skills    supporting    environment    stage    databases    interventions    healthcare    professional    imposes    experts    diabetes    date    employ    epidemic    fracture    cutting    biological    fidelio    aging    markers    broad    individual    develops    entrepreneurs    esrs    offers    models    vitro    collaborative    relative    quality    mineral    mechanisms    largely    bmd    mostly    multidisciplinary    unravelling    despite    unknown    individualized    lack    entrepreneurial    treatment    predictive    society    osteoporosis   

Project "FIDELIO" data sheet

The following table provides information about the project.

Coordinator
TECHNISCHE UNIVERSITAET DRESDEN 

Organization address
address: HELMHOLTZSTRASSE 10
city: DRESDEN
postcode: 1069
website: http://www.tu-dresden.de/

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Germany [DE]
 Total cost 3˙810˙146 €
 EC max contribution 3˙810˙146 € (100%)
 Programme 1. H2020-EU.1.3.1. (Fostering new skills by means of excellent initial training of researchers)
 Code Call H2020-MSCA-ITN-2019
 Funding Scheme MSCA-ITN-ETN
 Starting year 2019
 Duration (year-month-day) from 2019-10-01   to  2023-09-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    TECHNISCHE UNIVERSITAET DRESDEN DE (DRESDEN) coordinator 505˙576.00
2    SYDDANSK UNIVERSITET DK (ODENSE M) participant 595˙044.00
3    EIDGENOESSISCHE TECHNISCHE HOCHSCHULE ZUERICH CH (ZUERICH) participant 562˙553.00
4    ERASMUS UNIVERSITAIR MEDISCH CENTRUM ROTTERDAM NL (ROTTERDAM) participant 531˙239.00
5    UNIVERSITAETSKLINIKUM HAMBURG-EPPENDORF DE (HAMBURG) participant 505˙576.00
6    THE UNIVERSITY OF SHEFFIELD UK (SHEFFIELD) participant 303˙172.00
7    UNIVERSITE DE GENEVE CH (GENEVE) participant 281˙276.00
8    TAMIRNA GMBH AT (WIEN) participant 264˙207.00
9    UNIVERSITA CAMPUS BIO MEDICO DI ROMA IT (ROMA) participant 261˙499.00

Map

 Project objective

Diabetes mellitus has emerged as a novel risk factor for fragility fractures. While in type 1 diabetes the 3-fold overall relative risk for fractures may mostly derive from low bone mineral density (BMD) likely due to the lack of the bone-anabolic hormones, in type 2 diabetes, the fracture risk is increased about 2-fold, despite a normal or even higher BMD. This suggests that bone fragility in each form of diabetes develops by distinct mechanisms that to date remain largely unknown and may require an individualized approach for effective treatment. As the diabetes epidemic is increasing worldwide with aging, and the fractures that are associated with diabetes cause an increase in morbidity, mortality, and healthcare costs, diabetes-induced osteoporosis imposes a significant burden on our society and our healthcare system.

FIDELIO offers a comprehensive, multidisciplinary training program for Early Stage Researchers (ESRs) in this emerging field, unravelling i) the biological mechanisms that contribute to altered bone quality parameters with subsequent bone fragility in diabetes, ii) identify predictive markers for patient stratification and individualized interventions, and iii) develop novel imaging techniques to determine bone quality aspects. The research will employ well-defined patient cohorts, preclinical models of diabetic bone disease, in vitro studies, genetic databases, artificial intelligence, and cutting-edge imaging technologies in a highly collaborative and interdisciplinary environment. ESRs will be trained through individual research projects, secondments, residential courses, and webinars provided by a broad range of experts, including bone biologists, clinicians, epidemiologists, geneticists, engineers and entrepreneurs, as well as companies supporting this important area of research. The joint training programme will also develop transferable and entrepreneurial skills to help the ESRs succeed in their choice of professional future.

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