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LIGHT4LUNGS SIGNED

Inhalable Aerosol Light Source for Controlling Drug-Resistant Bacterial Lung Infections

Total Cost €

0

EC-Contrib. €

0

Partnership

0

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 LIGHT4LUNGS project word cloud

Explore the words cloud of the LIGHT4LUNGS project. It provides you a very rough idea of what is the project "LIGHT4LUNGS" about.

inhalable    science    lack    materials    profile    acquired    scheme    photosensitiser    extended    toxicity    excite    tethers    invasive    luminescence    combined    mortality    infections    internal    tests    bacterial    bacteria    scientific    resistance    antibiotics    paradigms    photosensitising    host    departs    source    reactive    breathable    photosensitisers    oxygen    healthcare    nanomedicine    lightning    eliminating    physical    aerosol    respiratory    treatment    models    photodynamic    self    species    advantage    lung    cystic    expertise    itself    multidrug    pathogenic    nanotechnology    porphyrins    fibrosis    iron    patients    externally    whereby    drug    avoiding    photonics    morbidity    chronic    sources    effect    clinically    added    light4lungs    irrespective    lungs    action    efficacy    combines    diseases    therapeutic    activation    tract    eliminated    endogenous    safe    particles    local    organs    persistent    encompasses    free    recalcitrant    antimicrobial    cytotoxic    elicit    definition    tissue    replaced    medicine    light    hospital   

Project "LIGHT4LUNGS" data sheet

The following table provides information about the project.

Coordinator
INSTITUT QUIMIC DE SARRIA 

Organization address
address: CALLE VIA AUGUSTA 384-394
city: Barcelona
postcode: 8017
website: www.iqs.edu

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Spain [ES]
 Total cost 3˙493˙625 €
 EC max contribution 3˙493˙625 € (100%)
 Programme 1. H2020-EU.1.2.1. (FET Open)
 Code Call H2020-FETOPEN-2018-2019-2020-01
 Funding Scheme RIA
 Starting year 2019
 Duration (year-month-day) from 2019-12-01   to  2023-11-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    INSTITUT QUIMIC DE SARRIA ES (Barcelona) coordinator 714˙375.00
2    UNIVERSITA DEGLI STUDI DI FIRENZE IT (Florence) participant 593˙125.00
3    THE UNIVERSITY OF LIVERPOOL UK (LIVERPOOL) participant 532˙500.00
4    UNIVERSITA DEGLI STUDI DI PADOVA IT (PADOVA) participant 410˙000.00
5    FUNDACIO PRIVADA INSTITUT CATALA D'INVESTIGACIO QUIMICA ES (TARRAGONA) participant 372˙500.00
6    CARDIFF SCINTIGRAPHICS LIMITED UK (CARDIFF) participant 336˙875.00
7    SORBONNE UNIVERSITE FR (PARIS) participant 294˙250.00
8    WEDO PROJECT INTELLIGENCE MADE EASY SL ES (BARCELONA) participant 240˙000.00

Map

 Project objective

Light4lungs addresses the problem of antimicrobial resistance in the treatment of chronic lung infections, which are the leading cause of morbidity and mortality in patients with diseases such as cystic fibrosis and hospital-acquired lung infections. The goal is to develop a novel therapeutic scheme for the treatment of the infections, whereby antibiotics will be replaced by inhalable light sources that will excite bacterial endogenous photosensitisers (e.g., iron-free porphyrins), eliminating the pathogenic bacteria by the photodynamic effect (local production of cytotoxic reactive oxygen species by the combined action of light, a photosensitiser and oxygen) irrespective of its multidrug resistance profile. The treatment will be safe for the host tissue because of its lack of self-photosensitising ability. Light4Lungs departs from current paradigms: (1) bacterial infections will be treated without antibiotics, which will be replaced by breathable light sources; (2) bacteria will be eliminated without any externally-added drug, taking advantage of endogenous photosensitisers; (3) a breathable light source will be used to elicit the therapeutic action, avoiding the use of invasive physical tethers to deliver light to the lungs. The project encompasses the development of particles with persistent luminescence, the aerosol technology for activation and delivery to the lungs, and the definition of the treatment parameters through toxicity and efficacy tests in clinically relevant models of respiratory infections. The project combines several different scientific expertise from photonics to medicine. The results will be useful for patients with recalcitrant respiratory tract bacterial infections and will eventually be extended to other diseases in the lungs and in other internal organs. The impact reaches beyond antimicrobial resistance itself and will affect many other fields such as healthcare, nanomedicine, materials science and nanotechnology and lightning

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The information about "LIGHT4LUNGS" are provided by the European Opendata Portal: CORDIS opendata.

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