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LIGHT4LUNGS SIGNED

Inhalable Aerosol Light Source for Controlling Drug-Resistant Bacterial Lung Infections

Total Cost €

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EC-Contrib. €

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Partnership

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LIGHT4LUNGS project word cloud

Explore the words cloud of the LIGHT4LUNGS project. It provides you a very rough idea of what is the project "LIGHT4LUNGS" about.

clinically departs light cytotoxic scientific advantage efficacy reactive antibiotics lung fibrosis bacterial invasive combined local photosensitiser inhalable luminescence morbidity multidrug models sources whereby recalcitrant photodynamic added free replaced tissue elicit self persistent externally respiratory profile eliminating particles tract eliminated tethers itself extended source scheme light4lungs chronic endogenous treatment pathogenic resistance patients physical lightning cystic breathable infections organs hospital diseases aerosol medicine lungs combines therapeutic mortality host irrespective tests healthcare science species materials effect photosensitisers activation nanotechnology expertise definition drug internal paradigms photosensitising acquired avoiding excite toxicity action lack porphyrins antimicrobial encompasses oxygen photonics safe bacteria nanomedicine iron

Project "LIGHT4LUNGS" data sheet

The following table provides information about the project.

Coordinator	INSTITUT QUIMIC DE SARRIA Organization address address: CALLE VIA AUGUSTA 384-394 city: Barcelona postcode: 8017 website: www.iqs.edu contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.
Coordinator Country	Spain [ES]
Total cost	3˙493˙625 €
EC max contribution	3˙493˙625 € (100%)
Programme	1. H2020-EU.1.2.1. (FET Open)
Code Call	H2020-FETOPEN-2018-2019-2020-01
Funding Scheme	RIA
Starting year	2019
Duration (year-month-day)	from 2019-12-01 to 2023-11-30

Partnership

Take a look of project's partnership.

#	participants	country	role	EC contrib. [€]
1	INSTITUT QUIMIC DE SARRIA INSTITUT QUIMIC DE SARRIA Organization address address: CALLE VIA AUGUSTA 384-394 city: Barcelona postcode: 8017 website: www.iqs.edu contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	ES (Barcelona)	coordinator	714˙375.00
2	UNIVERSITA DEGLI STUDI DI FIRENZE UNIVERSITA DEGLI STUDI DI FIRENZE Organization address address: Piazza San Marco 4 city: Florence postcode: 50121 website: http://www.unifi.it contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	IT (Florence)	participant	593˙125.00
3	THE UNIVERSITY OF LIVERPOOL THE UNIVERSITY OF LIVERPOOL Organization address address: BROWNLOW HILL 765 FOUNDATION BUILDING city: LIVERPOOL postcode: L69 7ZX website: www.liverpool.ac.uk contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	UK (LIVERPOOL)	participant	532˙500.00
4	UNIVERSITA DEGLI STUDI DI PADOVA UNIVERSITA DEGLI STUDI DI PADOVA Organization address address: VIA 8 FEBBRAIO 2 city: PADOVA postcode: 35122 website: www.unipd.it contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	IT (PADOVA)	participant	410˙000.00
5	FUNDACIO PRIVADA INSTITUT CATALA D'INVESTIGACIO QUIMICA FUNDACIO PRIVADA INSTITUT CATALA D'INVESTIGACIO QUIMICA Organization address address: AVENIDA PAISSOS CATALANS 16 city: TARRAGONA postcode: 43007 website: www.iciq.es contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	ES (TARRAGONA)	participant	372˙500.00
6	CARDIFF SCINTIGRAPHICS LIMITED CARDIFF SCINTIGRAPHICS LIMITED Organization address address: CARDIFF MEDICENTRE, HEATH PARK city: CARDIFF postcode: CF14 4UJ website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	UK (CARDIFF)	participant	336˙875.00
7	SORBONNE UNIVERSITE SORBONNE UNIVERSITE Organization address address: 21 RUE DE L'ECOLE DE MEDECINE city: PARIS postcode: 75006 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	FR (PARIS)	participant	294˙250.00
8	WEDO PROJECT INTELLIGENCE MADE EASY SL WEDO PROJECT INTELLIGENCE MADE EASY SL Organization address address: CALLE ROSSELLO 248, PLANTA 5, PUERTA 2 city: BARCELONA postcode: 8008 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	ES (BARCELONA)	participant	240˙000.00

Map

Project objective

Light4lungs addresses the problem of antimicrobial resistance in the treatment of chronic lung infections, which are the leading cause of morbidity and mortality in patients with diseases such as cystic fibrosis and hospital-acquired lung infections. The goal is to develop a novel therapeutic scheme for the treatment of the infections, whereby antibiotics will be replaced by inhalable light sources that will excite bacterial endogenous photosensitisers (e.g., iron-free porphyrins), eliminating the pathogenic bacteria by the photodynamic effect (local production of cytotoxic reactive oxygen species by the combined action of light, a photosensitiser and oxygen) irrespective of its multidrug resistance profile. The treatment will be safe for the host tissue because of its lack of self-photosensitising ability. Light4Lungs departs from current paradigms: (1) bacterial infections will be treated without antibiotics, which will be replaced by breathable light sources; (2) bacteria will be eliminated without any externally-added drug, taking advantage of endogenous photosensitisers; (3) a breathable light source will be used to elicit the therapeutic action, avoiding the use of invasive physical tethers to deliver light to the lungs. The project encompasses the development of particles with persistent luminescence, the aerosol technology for activation and delivery to the lungs, and the definition of the treatment parameters through toxicity and efficacy tests in clinically relevant models of respiratory infections. The project combines several different scientific expertise from photonics to medicine. The results will be useful for patients with recalcitrant respiratory tract bacterial infections and will eventually be extended to other diseases in the lungs and in other internal organs. The impact reaches beyond antimicrobial resistance itself and will affect many other fields such as healthcare, nanomedicine, materials science and nanotechnology and lightning

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The information about "LIGHT4LUNGS" are provided by the European Opendata Portal: CORDIS opendata.

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