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NEUREKA SIGNED

A smart, hybrid neural-computo device for drug discovery

Total Cost €

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EC-Contrib. €

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Partnership

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 NEUREKA project word cloud

Explore the words cloud of the NEUREKA project. It provides you a very rough idea of what is the project "NEUREKA" about.

branches    subcellular    economical    complementing    societal    innovative    candidates    simulated    hybrid    closing    physiological    akin    shift    replicate    exacerbating    unprecedented    soma    cell    neuronal    pathology    drug    back    incurable    vitro    replication    neural    contact    neureka    stem    monitor    models    transmission    proof    alzheimer    tree    dendritic    locations    loop    circuits    fed    pathological    neurological    multiple    mediate    faithfully    burden    neurodegeneration    pluripotent    brain    drive    accuracy    exhibiting    assays    computational    dysfunction    compounds    repeated    lack    axonal    disease    synapses    human    cultured    culture    discovery    simulate    functions    molecular    functional    drugs    optimize    networks    excitability    cellular    reproducing    registered    biological    diseases    failures    population    suffers    synaptic    standard    whereby    effect    shortcoming    deficits    network    neurons    nanoelectrodes    levels    paradigm    candidate    emerge    introduces    quantification    ipsc   

Project "NEUREKA" data sheet

The following table provides information about the project.

Coordinator
IDRYMA TECHNOLOGIAS KAI EREVNAS 

Organization address
address: N PLASTIRA STR 100
city: IRAKLEIO
postcode: 70013
website: www.forth.gr

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Greece [EL]
 Total cost 2˙776˙705 €
 EC max contribution 2˙776˙704 € (100%)
 Programme 1. H2020-EU.1.2.1. (FET Open)
 Code Call H2020-FETOPEN-2018-2019-2020-01
 Funding Scheme RIA
 Starting year 2019
 Duration (year-month-day) from 2019-12-01   to  2023-11-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    IDRYMA TECHNOLOGIAS KAI EREVNAS EL (IRAKLEIO) coordinator 753˙250.00
2    CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS FR (PARIS) participant 756˙452.00
3    MAXWELL BIOSYSTEMS AG CH (ZURICH) participant 466˙562.00
4    UNIVERSITA DEGLI STUDI DI PADOVA IT (PADOVA) participant 465˙440.00
5    UNIVERSITA' DEGLI STUDI DI MILANO-BICOCCA IT (MILANO) participant 335˙000.00

Map

 Project objective

NEUREKA will bring a paradigm shift in drug discovery for neurological diseases, a sector that suffers multiple, repeated failures exacerbating the economical and societal burden of these incurable diseases. It will do so by addressing a crucial shortcoming: the lack of in vitro systems faithfully reproducing brain pathology that enable the functional assessment of candidate compounds at multiple levels: from synapses to neuronal circuits. NEUREKA introduces an innovative, hybrid technology, whereby detailed, computational neuronal networks simulate dysfunction and drive cultured neurons to replicate in-brain disease conditions. Nanoelectrodes mediate the transmission between simulated and biological neurons. Akin to real synapses, nanoelectrodes contact cultured neurons at subcellular locations across the dendritic tree, soma and axonal branches, allowing to control and monitor neural activity with unprecedented accuracy. Biological neuronal responses registered by nanoelectrodes are fed back to simulated neurons, closing the loop and enabling control of activity states across the hybrid population. Complementing molecular deficits already present in culture models of a disease, computational models enable replication of both molecular and physiological deficits of neurodegeneration in vitro. Cultured neurons are driven towards pathological excitability states where deficits emerge, so as to optimize quantification of the impact of drugs, going well beyond standard cellular assays. A proof-of-concept will be provided for Alzheimer’s disease, using human induced pluripotent stem cell (iPSC)-derived neurons exhibiting the pathology. NEUREKA will be used to demonstrate the effect of drug candidates across synaptic, neuronal and network functions.

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The information about "NEUREKA" are provided by the European Opendata Portal: CORDIS opendata.

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