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SUMiDENTITY SIGNED

Deconstructing the role of SUMO on chromatin in cell identity and tissue repair

Total Cost €

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EC-Contrib. €

0

Partnership

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 SUMiDENTITY project word cloud

Explore the words cloud of the SUMiDENTITY project. It provides you a very rough idea of what is the project "SUMiDENTITY" about.

avenues    gene    identities    accompanies    resisting    configurations    escs    druggable    poorly    bound    experimental    muscle    existence    reprogramming    reciprocally    notably    toward    deposits    fibroblasts    interplay    pluripotent    fate    stabilizer    substrates    transition    distinctive    paradigm    underlying    sumoylation    central    desumoylation    deconjugating    determined    sumo    plays    repair    complementary    identity    transcriptional    opening    maintaining    chromosomal    treatment    molecular    regulators    conjugating    uncovered    pathophysiological    integrate    dynamics    effort    explore    equilibrium    paradigmatic    regulatory    mark    corrupted    disease    questions    vision    regulating    barrier    regulated    transitions    subverted    chromatin    locus    biology    enforces    somatic    critical    medicine    principally    maintenance    dynamic    injury    cancer    complexes    specifications    balance    cellular    mechanism    loci    roles    function    functions    rapid    regenerative    determinants    specify    types    transcription    acts    safeguard    pluripotency    totipotent    provides    actively    mechanisms    cell    tissue   

Project "SUMiDENTITY" data sheet

The following table provides information about the project.

Coordinator
INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE 

Organization address
address: RUE DE TOLBIAC 101
city: PARIS
postcode: 75654
website: www.inserm.fr

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country France [FR]
 Total cost 2˙499˙995 €
 EC max contribution 2˙499˙995 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2018-ADG
 Funding Scheme ERC-ADG
 Starting year 2020
 Duration (year-month-day) from 2020-01-01   to  2024-12-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE FR (PARIS) coordinator 2˙499˙995.00

Map

 Project objective

The maintenance of cell identity and how it is subverted in disease are central questions in biology and medicine. The interplay between transcription factor and chromatin configurations plays a key role in maintaining cellular identity, yet how this interplay is regulated is poorly understood. Notably, the existence of possible general mechanisms underlying different cell-state specifications remains to be determined. We have recently uncovered evidence that sumoylation, which deposits a chromatin-associated mark (SUMO) that principally targets transcriptional regulators, acts as a general barrier to cell-fate transitions and enforces two distinctive chromatin types to safeguard somatic and pluripotent cell identities. The central paradigm for the proposed work is that SUMO functions as a general stabilizer of critical chromatin-bound determinants of cell identity and that the equilibrium between conjugating/deconjugating activities provides a general regulatory mechanism for their dynamic targeting to key chromosomal loci, thus actively contributing to cell-fate change. Focusing on reprogramming to pluripotency and transition to totipotent-like states, we propose to: 1) identify relevant locus-specific SUMO substrates/complexes in fibroblasts and ESCs, 2) define the role of SUMO in regulating their function and dynamics and, reciprocally, 3) explore the sumoylation/desumoylation balance that accompanies cell-fate change. A complementary effort seeks 4) to exploit these experimental approaches to study a paradigmatic pathophysiological process involving rapid cell-fate transitions: tissue repair following muscle injury. With a vision toward targeting this druggable pathway for regenerative medicine and cancer treatment, we expect these studies to integrate the gene regulatory roles of SUMO in resisting cell-fate change, thus opening up new avenues to the molecular mechanisms that specify cell identity during development and to how they are corrupted in disease.

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