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cmRNAbone SIGNED

3D Printed-Matrix Assisted Chemically Modified RNAs Bone Regenerative Therapy for Trauma and Osteoporotic Patients

Total Cost €

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EC-Contrib. €

0

Partnership

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 cmRNAbone project word cloud

Explore the words cloud of the cmRNAbone project. It provides you a very rough idea of what is the project "cmRNAbone" about.

group    effort    fracture    neurons    1st    conjunction    candidate    patients    presenting    vitro    intrinsic    promises    bioprinting    economic    strategies    nanocapsules    regulatory    release    formulations    phosphate    hyaluronan    laminin    create    facilities    cmrnas    preclinical    ingrowth    dosage    life    sensory    solutions    printing    3d    clinical    calcium    due    commercial    lipids    style    printer    tools    formulated    injuries    biomaterial    printed    overreaching    regenerative    medical    therapies    bb    peptides    synthesized    bmp7    fabrication    experts    guiding    enormous    trial    combination    osteoinductivity    optimizing    auditing    neurogenesis    rnas    vivo    preparing    solution    osteoporosis    ageing    realized    cmrnabone    chemically    endothelial    extrusion    modified    loaded    ratio    functional    gmp    traumatic    keeping    human    vasculogenesis    vegf    proof    deciphering    amenable    consisting    socio    bone    nations    patient    clinically    pdgf    industrialized    ink    cells    osteogenesis    mechanisms    until    polysaccharide    loading    vectors    fragile    failed    sema3a    therapeutic   

Project "cmRNAbone" data sheet

The following table provides information about the project.

Coordinator
AO-FORSCHUNGSINSTITUT DAVOS 

Organization address
address: CLAVADELERSTRASSE 8
city: DAVOS PLATZ
postcode: 7270
website: www.aofoundation.org

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Switzerland [CH]
 Total cost 6˙256˙758 €
 EC max contribution 6˙256˙758 € (100%)
 Programme 1. H2020-EU.3.1.3. (Treating and managing disease)
 Code Call H2020-SC1-2019-Single-Stage-RTD
 Funding Scheme RIA
 Starting year 2020
 Duration (year-month-day) from 2020-01-01   to  2023-12-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    AO-FORSCHUNGSINSTITUT DAVOS CH (DAVOS PLATZ) coordinator 710˙750.00
2    UNIVERSITE DE BORDEAUX FR (BORDEAUX) participant 1˙117˙558.00
3    UNIVERSITEIT MAASTRICHT NL (MAASTRICHT) participant 999˙748.00
4    UNIVERSITAT BASEL CH (BASEL) participant 659˙570.00
5    ETHRIS GMBH DE (PLANEGG) participant 490˙526.00
6    EURICE EUROPEAN RESEARCH AND PROJECT OFFICE GMBH DE (ST INGBERT) participant 457˙500.00
7    OZ BIOSCIENCES SAS FR (MARSEILLE) participant 447˙750.00
8    FUNDACION CIDETEC ES (SAN SEBASTIAN) participant 443˙500.00
9    KUROS BIOSCIENCES BV NL (BILTHOVEN) participant 435˙138.00
10    FUNDACION IDONIAL ES (GIJON) participant 310˙500.00
11    QBEX GMBH AT (KLAGENFURT) participant 184˙216.00

Map

 Project objective

Due to life style changes and ageing of our industrialized nations, bone traumatic injuries and osteoporosis induced fragile fracture are an enormous medical and socio-economic challenge. State-of-the-art therapies have failed until now in keeping their promises of reliable bone regenerative solutions. The cmRNAbone project aim to create a novel bone regenerative therapeutic approach based on combination of chemically modified RNAs (cmRNAs)-vectors embedded in a 3D-printed guiding biomaterial ink tailored to patients need. To achieve our goal, sema3a, vegf, pdgf-bb and bmp7 cmRNAs targeting neurogenesis, vasculogenesis and osteogenesis will be synthesized, vectors based on lipids and polysaccharide nanocapsules for the delivery of cmRNAs will be developed. A functional Hyaluronan-Calcium Phosphate biomaterial ink that 1) can be loaded with cmRNAs-vectors and release them, 2) having intrinsic osteoinductivity and presenting laminin-derived peptides for guiding sensory neurons and endothelial cells ingrowth, and 3) being amenable to an extrusion-based 3D-bioprinting process will be formulated in conjunction to a 3D-printer for fabrication of patient specific regenerative solution. In the following step, a large effort will focus on deciphering regenerative mechanisms and optimizing dosage and ratio of cmRNAs, loading of cmRNAs-vectors in the ink, 3D-printing, etc, to demonstrate regenerative capabilities in vitro and in vivo. Selected candidate formulations will be taken to clinically relevant preclinical proof of concepts. Finally, an overreaching effort on preparing a 1st in human trial will be taken, consisting on partners facilities auditing and clinical experts group support, etc, to ensure that GMP-like production for all regenerative tools, and regulatory and commercial strategies are realized.

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The information about "CMRNABONE" are provided by the European Opendata Portal: CORDIS opendata.

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