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cmRNAbone SIGNED

3D Printed-Matrix Assisted Chemically Modified RNAs Bone Regenerative Therapy for Trauma and Osteoporotic Patients

Total Cost €

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EC-Contrib. €

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Partnership

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cmRNAbone project word cloud

Explore the words cloud of the cmRNAbone project. It provides you a very rough idea of what is the project "cmRNAbone" about.

presenting preparing preclinical human loaded lipids bioprinting realized ratio calcium promises injuries vasculogenesis proof traumatic bb therapies fabrication style deciphering regenerative osteoporosis create therapeutic extrusion gmp socio pdgf trial group guiding modified vivo formulated cells mechanisms cmrnas nanocapsules bone until conjunction 3d phosphate nations regulatory sema3a patients fragile enormous chemically synthesized polysaccharide optimizing candidate printer dosage amenable vitro ageing sensory printing experts osteoinductivity loading hyaluronan neurons neurogenesis functional biomaterial release ingrowth cmrnabone overreaching peptides ink printed keeping endothelial 1st solutions due formulations strategies medical laminin economic industrialized clinically auditing life combination consisting effort vegf tools solution patient commercial osteogenesis clinical bmp7 rnas failed fracture intrinsic vectors facilities

Project "cmRNAbone" data sheet

The following table provides information about the project.

Coordinator	AO-FORSCHUNGSINSTITUT DAVOS Organization address address: CLAVADELERSTRASSE 8 city: DAVOS PLATZ postcode: 7270 website: www.aofoundation.org contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.
Coordinator Country	Switzerland [CH]
Total cost	6˙256˙758 €
EC max contribution	6˙256˙758 € (100%)
Programme	1. H2020-EU.3.1.3. (Treating and managing disease)
Code Call	H2020-SC1-2019-Single-Stage-RTD
Funding Scheme	RIA
Starting year	2020
Duration (year-month-day)	from 2020-01-01 to 2023-12-31

Partnership

Take a look of project's partnership.

#	participants	country	role	EC contrib. [€]
1	AO-FORSCHUNGSINSTITUT DAVOS AO-FORSCHUNGSINSTITUT DAVOS Organization address address: CLAVADELERSTRASSE 8 city: DAVOS PLATZ postcode: 7270 website: www.aofoundation.org contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	CH (DAVOS PLATZ)	coordinator	710˙750.00
2	UNIVERSITE DE BORDEAUX UNIVERSITE DE BORDEAUX Organization address address: PLACE PEY BERLAND 35 city: BORDEAUX postcode: 33000 website: www.nouvelle-univ-bordeaux.fr contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	FR (BORDEAUX)	participant	1˙117˙558.00
3	UNIVERSITEIT MAASTRICHT UNIVERSITEIT MAASTRICHT Organization address address: Minderbroedersberg 4-6 city: MAASTRICHT postcode: 6200 MD website: http://www.maastrichtuniversity.nl contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	NL (MAASTRICHT)	participant	999˙748.00
4	UNIVERSITAT BASEL UNIVERSITAT BASEL Organization address address: PETERSPLATZ 1 city: BASEL postcode: 4051 website: www.unibas.ch contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	CH (BASEL)	participant	659˙570.00
5	ETHRIS GMBH ETHRIS GMBH Organization address address: SEMMELWEISSTR. 3 city: PLANEGG postcode: 82152 website: www.ethris.com contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	DE (PLANEGG)	participant	490˙526.00
6	EURICE EUROPEAN RESEARCH AND PROJECT OFFICE GMBH EURICE EUROPEAN RESEARCH AND PROJECT OFFICE GMBH Organization address address: HEINRICH-HERTZ-ALLEE 1 city: ST INGBERT postcode: 66386 website: www.eurice.eu contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	DE (ST INGBERT)	participant	457˙500.00
7	OZ BIOSCIENCES SAS OZ BIOSCIENCES SAS Organization address address: PARC SCIENTIFIQUE ET TECHNOLOGIQUE DE LUMINY CASE 922 BAT CCIMP city: MARSEILLE postcode: 13288 website: www.ozbiosciences.com contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	FR (MARSEILLE)	participant	447˙750.00
8	FUNDACION CIDETEC FUNDACION CIDETEC Organization address address: PASEO MIRAMON 196 PARQUE TECNOLOGICO DE MIRAMON city: SAN SEBASTIAN postcode: 20014 website: www.cidetec.es contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	ES (SAN SEBASTIAN)	participant	443˙500.00
9	KUROS BIOSCIENCES BV KUROS BIOSCIENCES BV Organization address address: PROFESSOR BRONKHORSTLAAN 10 G 48 city: BILTHOVEN postcode: 3723 MB website: www.xpand-biotech.com contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	NL (BILTHOVEN)	participant	435˙138.00
10	FUNDACION IDONIAL FUNDACION IDONIAL Organization address address: AVENIDA JARDIN BOTANICO 1345 PARQUE CIENTIFICO Y TECNOLOGICO ZONA INTRA city: GIJON postcode: 33203 website: www.prodintec.com contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	ES (GIJON)	participant	310˙500.00
11	QBEX GMBH QBEX GMBH Organization address address: ST. VEITER RING 1A city: KLAGENFURT postcode: 9020 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	AT (KLAGENFURT)	participant	184˙216.00

Map

Project objective

Due to life style changes and ageing of our industrialized nations, bone traumatic injuries and osteoporosis induced fragile fracture are an enormous medical and socio-economic challenge. State-of-the-art therapies have failed until now in keeping their promises of reliable bone regenerative solutions. The cmRNAbone project aim to create a novel bone regenerative therapeutic approach based on combination of chemically modified RNAs (cmRNAs)-vectors embedded in a 3D-printed guiding biomaterial ink tailored to patients need. To achieve our goal, sema3a, vegf, pdgf-bb and bmp7 cmRNAs targeting neurogenesis, vasculogenesis and osteogenesis will be synthesized, vectors based on lipids and polysaccharide nanocapsules for the delivery of cmRNAs will be developed. A functional Hyaluronan-Calcium Phosphate biomaterial ink that 1) can be loaded with cmRNAs-vectors and release them, 2) having intrinsic osteoinductivity and presenting laminin-derived peptides for guiding sensory neurons and endothelial cells ingrowth, and 3) being amenable to an extrusion-based 3D-bioprinting process will be formulated in conjunction to a 3D-printer for fabrication of patient specific regenerative solution. In the following step, a large effort will focus on deciphering regenerative mechanisms and optimizing dosage and ratio of cmRNAs, loading of cmRNAs-vectors in the ink, 3D-printing, etc, to demonstrate regenerative capabilities in vitro and in vivo. Selected candidate formulations will be taken to clinically relevant preclinical proof of concepts. Finally, an overreaching effort on preparing a 1st in human trial will be taken, consisting on partners facilities auditing and clinical experts group support, etc, to ensure that GMP-like production for all regenerative tools, and regulatory and commercial strategies are realized.

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The information about "CMRNABONE" are provided by the European Opendata Portal: CORDIS opendata.

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