Explore the words cloud of the MtbTransReg project. It provides you a very rough idea of what is the project "MtbTransReg" about.
The following table provides information about the project.
Coordinator |
LONDON SCHOOL OF HYGIENE AND TROPICAL MEDICINE ROYAL CHARTER
Organization address contact info |
Coordinator Country | United Kingdom [UK] |
Project website | https://blogs.lshtm.ac.uk/corteslab/research-2/ |
Total cost | 1˙495˙625 € |
EC max contribution | 1˙495˙625 € (100%) |
Programme |
1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC)) |
Code Call | ERC-2014-STG |
Funding Scheme | ERC-STG |
Starting year | 2015 |
Duration (year-month-day) | from 2015-06-01 to 2021-05-31 |
Take a look of project's partnership.
# | ||||
---|---|---|---|---|
1 | LONDON SCHOOL OF HYGIENE AND TROPICAL MEDICINE ROYAL CHARTER | UK (LONDON) | coordinator | 1˙495˙625.00 |
Mycobacterium tuberculosis causes human tuberculosis but can also persist for decades as an asymptomatic latent infection. The mechanisms underlying persistence are poorly understood, and the emergence of drug-resistant tuberculosis makes the development of effective new treatments an urgent challenge. Understanding the ability of M. tuberculosis to switch between replicating and non-replicating states during infection and disease is central to the search for improved treatments. The number of copies of a protein produced by a cell is generally viewed as being determined by the number of mRNA transcripts, but recent findings suggest that ‘specialised ribosomes’ can modify proteome profiles by preferential translation of particular mRNA subsets, particularly in response to stress. mRNA molecules contain specific signals that optimise their interaction with ribosomes; known as leader sequences, these include the Shine-Dalgarno (SD) sequence required for canonical translation initiation in bacteria. I recently demonstrated that M. tuberculosis expresses an unexpected number of leaderless mRNA transcripts that lack the SD sequence. In Escherichia coli, only a few leaderless transcripts have been described and they are selectively translated by specialised ribosomes. I propose to test the hypothesis that differential translation of mRNA subsets contributes to M. tuberculosis persistence and drug susceptibility. I will investigate the importance of selective translation of leaderless and SD mRNAs in the context of adaptation to stress and drug resistance in M. tuberculosis, using cutting-edge experimental techniques combined with bioinformatic analyses. The proposed project addresses the fundamental systems biology challenge of establishing quantitative correlations between transcriptome and proteome data, and beyond contributing to the rational design of novel treatments to cure tuberculosis, could help to re-shape classical paradigms of bacterial gene regulation.
year | authors and title | journal | last update |
---|---|---|---|
2019 |
Dimitrios Evangelopoulos, Gareth A. Prosser, Angela Rodgers, Belinda M. Dagg, Bhagwati Khatri, Mei Mei Ho, Maximiliano G. Gutierrez, Teresa Cortes, Luiz Pedro S. de Carvalho Comparative fitness analysis of D-cycloserine resistant mutants reveals both fitness-neutral and high-fitness cost genotypes published pages: , ISSN: 2041-1723, DOI: 10.1038/s41467-019-12074-z |
Nature Communications 10/1 | 2020-02-04 |
2019 |
Ãlvaro Chiner-Oms, Michael Berney, Christine Boinett, Fernando González-Candelas, Douglas B. Young, Sebastien Gagneux, William R. Jacobs, Julian Parkhill, Teresa Cortes, Iñaki Comas Genome-wide mutational biases fuel transcriptional diversity in the Mycobacterium tuberculosis complex published pages: , ISSN: 2041-1723, DOI: 10.1038/s41467-019-11948-6 |
Nature Communications 10/1 | 2020-01-24 |
2018 |
Elizabeth B Sawyer, Anna D Grabowska, Teresa Cortes Translational regulation in mycobacteria and its implications for pathogenicity published pages: 6950-6961, ISSN: 0305-1048, DOI: 10.1093/nar/gky574 |
Nucleic Acids Research 46/14 | 2020-01-24 |
2017 |
Teresa Cortes, Olga T. Schubert, Amir Banaei-Esfahani, Ben C. Collins, Ruedi Aebersold, Douglas B. Young Delayed effects of transcriptional responses in Mycobacterium tuberculosis exposed to nitric oxide suggest other mechanisms involved in survival published pages: , ISSN: 2045-2322, DOI: 10.1038/s41598-017-08306-1 |
Scientific Reports 7/1 | 2020-01-24 |
Are you the coordinator (or a participant) of this project? Plaese send me more information about the "MTBTRANSREG" project.
For instance: the website url (it has not provided by EU-opendata yet), the logo, a more detailed description of the project (in plain text as a rtf file or a word file), some pictures (as picture files, not embedded into any word file), twitter account, linkedin page, etc.
Send me an email (fabio@fabiodisconzi.com) and I put them in your project's page as son as possible.
Thanks. And then put a link of this page into your project's website.
The information about "MTBTRANSREG" are provided by the European Opendata Portal: CORDIS opendata.
High-throughput single-cell phenotypic analysis of functional antibody repertoires
Read MoreWhy is the world green: testing top-down control of plant-herbivore food webs by experiments with birds, bats and ants
Read MoreUnderstanding and leveraging ‘moments of change’ for pro-environmental behaviour shifts
Read More