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ESCALON SIGNED

European-Latin American network for the assessment of biomarkers to predict and diagnose hepatobiliary malignancies and characterization of risk factors for cancer development

Total Cost €

EC-Contrib. €

Partnership

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ESCALON project word cloud

Explore the words cloud of the ESCALON project. It provides you a very rough idea of what is the project "ESCALON" about.

detection cancer therapies manner leads geographical gallbladder screen south dramatically death mortality diagnosis regions difficult markers poor stages tools hepatobiliary tissue tumor lack serum extracellular burden overcome america largely complexity limited amplified therapy latin modifiable utility barriers diagnose malignancies uniquely cholangiocarcinoma imaging curative biomarkers visible easily hepatocellular prevention screening carcinoma minimal representing region women option excessive young diagnosed rare predict worldwide understudied tumors vesicles globally validate individuals cca accessibility aggressive accessible immune chile risk infectious hcc survival genetic resource reduce gbc

Project "ESCALON" data sheet

The following table provides information about the project.

Coordinator	ERASMUS UNIVERSITAIR MEDISCH CENTRUM ROTTERDAM Organization address address: DR MOLEWATERPLEIN 40 city: ROTTERDAM postcode: 3015 GD website: www.erasmusmc.nl contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.
Coordinator Country	Netherlands [NL]
Total cost	3˙503˙475 €
EC max contribution	3˙283˙475 € (94%)
Programme	1. H2020-EU.3.1.3. (Treating and managing disease)
Code Call	H2020-SC1-2018-Single-Stage-RTD
Funding Scheme	RIA
Starting year	2019
Duration (year-month-day)	from 2019-01-01 to 2022-12-31

Partnership

Take a look of project's partnership.

#	participants	country	role	EC contrib. [€]
1	ERASMUS UNIVERSITAIR MEDISCH CENTRUM ROTTERDAM ERASMUS UNIVERSITAIR MEDISCH CENTRUM ROTTERDAM Organization address address: DR MOLEWATERPLEIN 40 city: ROTTERDAM postcode: 3015 GD website: www.erasmusmc.nl contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	NL (ROTTERDAM)	coordinator	1˙386˙725.00
2	ASOCIACION INSTITUTO BIODONOSTIA ASOCIACION INSTITUTO BIODONOSTIA Organization address address: Paseo Dr. Beguiristain s/n city: DONOSTIA-SAN SEBASTIAN postcode: 20014 website: www.biodonostia.org contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	ES (DONOSTIA-SAN SEBASTIAN)	participant	550˙000.00
3	PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE Organization address address: AVENIDA LIBERTADOR BERNARDO O'HIGGINS 340 city: SANTIAGO postcode: 8331150 website: www.uc.cl contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	CL (SANTIAGO)	participant	430˙000.00
4	HOSPIAL PRIVADO CENTRO MEDICO DE CORDOBA SA HOSPIAL PRIVADO CENTRO MEDICO DE CORDOBA SA Organization address address: AVENIDA NACIONES UNIDAS 346 city: CORDOBA postcode: 5016 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	AR (CORDOBA)	participant	301˙250.00
5	UNIVERSIDAD SAN FRANCISCO DE QUITO UNIVERSIDAD SAN FRANCISCO DE QUITO Organization address address: CALLE DIEGO DE ROBLES S N Y PAMPITE ESQ city: QUITO postcode: 1712145 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	EC (QUITO)	participant	172˙750.00
6	MEDIZINISCHE HOCHSCHULE HANNOVER MEDIZINISCHE HOCHSCHULE HANNOVER Organization address address: Carl-Neuberg-Strasse 1 city: HANNOVER postcode: 30625 website: www.mh-hannover.de contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	DE (HANNOVER)	participant	145˙000.00
7	CENTRO DE ENFERMEDADES HEPATICAS Y DIGESTIVAS SAS CENTRO DE ENFERMEDADES HEPATICAS Y DIGESTIVAS SAS Organization address address: CALLE 127 NO 19 A 28 city: BOGOTA postcode: 110121 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	CO (BOGOTA)	participant	117˙750.00
8	SENSU HOLDING BV SENSU HOLDING BV Organization address address: EMMAPLEIN 1 city: GRONINGEN postcode: 9711 AP website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	NL (GRONINGEN)	participant	95˙000.00
9	THE UNIVERSITY OF MANCHESTER THE UNIVERSITY OF MANCHESTER Organization address address: OXFORD ROAD city: MANCHESTER postcode: M13 9PL website: www.manchester.ac.uk contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	UK (MANCHESTER)	participant	85˙000.00
10	FUNDACAO UNIVERSIDADE FEDERAL DE CIENCIAS DA SAUDE DE PORTO ALEGRE FUNDACAO UNIVERSIDADE FEDERAL DE CIENCIAS DA SAUDE DE PORTO ALEGRE Organization address address: RUA SARMENTO LEITE 245 city: PORTO ALEGRE postcode: 90050 170 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	BR (PORTO ALEGRE)	participant	0.00
11	THE GOVERNING COUNCIL OF THE UNIVERSITY OF TORONTO THE GOVERNING COUNCIL OF THE UNIVERSITY OF TORONTO Organization address address: KINGS COLLEGE CIRCLE 27 city: TORONTO postcode: M5S 1A1 website: http://www.utoronto.ca/ contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	CA (TORONTO)	participant	0.00

Map

Project objective

Hepatobiliary malignancies represent a major cause of mortality globally and are uniquely aggressive in Latin America. The most common tumors are: hepatocellular carcinoma (HCC) affecting young individuals in Latin America and being the second most common cause of cancer-related death worldwide; cholangiocarcinoma (CCA) with minimal survival upon diagnosis and largely understudied in the region; gallbladder cancer (GBC) being a rare tumor worldwide but representing the second most common cause of cancer-related death in women in Chile. Key factors related to the excessive mortality of these tumors are the lack of reliable screening methods and the complexity of diagnosis, which requires advanced imaging technology and difficult-to-access tissue. These barriers are amplified by poor accessibility present in resource-limited regions, all of which leads to tumors being diagnosed at advanced stages in which curative therapy is not an option. To overcome these barriers, we propose to: A) validate immune-related markers in serum to predict HCC in South America and evaluate factors associated to early HCC development; B) define the utility of extracellular vesicles in serum as biomarkers for diagnosis of CCA and determine genetic and infectious factors that increase risk for this cancer; and C) identify biomarkers for GBC detection and evaluate novel immune factors that affect the geographical impact of this tumor. This project advances the field by focusing on a unique approach to screen and diagnose tumors based on serum detection of biomarkers before a tumor is visible on imaging, allowing for early tumor detection in a cost effective manner that will lead to implementation of curative therapies. In addition, this project addresses modifiable risk factors for hepatobiliary tumors that could be targeted for prevention. This project will result in novel tools that are easily accessible and will dramatically reduce the burden of cancer-related mortality in Latin America.

Publications

List of publications.
year	authors and title	journal	last update
2019	Jesus M. Banales, Mercedes IÃ±arrairaegui, Ander Arbelaiz, Piotr Milkiewicz, Jordi MuntanÃ©, Luis MuÃ±oz-Bellvis, Adelaida La Casta, Luis M. Gonzalez, Enara Arretxe, Cristina Alonso, Ibon MartÃnez-Arranz, Ainhoa Lapitz, Alvaro Santos-Laso, Matias A. Avila, Maria L. MartÃnez-Chantar, Luis Bujanda, Jose J.G. Marin, Bruno Sangro, Rocio I.R. Macias Serum Metabolites as Diagnostic Biomarkers for Cholangiocarcinoma, Hepatocellular Carcinoma, and Primary Sclerosing Cholangitis published pages: 547-562, ISSN: 0270-9139, DOI: 10.1002/hep.30319	Hepatology 70/2	2020-04-21
2019	Jose D Debes, Andre Boonstra, Domingo Balderramo, Angelo Z Mattos, Marco Arrese, Juan C. Roa, Juan W. Valle, Jesus M. Banales, Enrique Carrera, Pablo A. Romagnoli, Jhon E. Prieto, Bettina E. Hansen, Arndt Vogel, Angela Lamarca Hepatobiliary cancers in South America: disparity strikes published pages: 581, ISSN: 2468-1253, DOI: 10.1016/s2468-1253(19)30188-8	The Lancet Gastroenterology & Hepatology 4/8	2020-04-21

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The information about "ESCALON" are provided by the European Opendata Portal: CORDIS opendata.