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SBR SIGNED

SMART BONE REGENERATION

Total Cost €

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EC-Contrib. €

0

Partnership

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SBR project word cloud

Explore the words cloud of the SBR project. It provides you a very rough idea of what is the project "SBR" about.

allografts healthcare vitro fibers adjustable preclinical reconstruction elaborated of immunorejection medical characterization patient resorbable placement monitoring tested inflammation smart aged autografts temperature parts polymers scope electrospun injury cells printed bioactive adjustement proper agents specifications performance sbr suitable electronic minimal stem bone srb global customized engineering regulatory vivo innovative animal strategy compatibility gender vital fast regenerative pathology chain embedding population introduces defects biocompatible infection implant mechanical communication embed programming commercialization proof clinical strategies ideal tissue suffer ph restoration treatment inspired solution sensors scaffold model conductive identification pressure limited particulate efficacy enriched explore 3d physiology grade inks conventional

Project "SBR" data sheet

The following table provides information about the project.

Coordinator	PANEPISTIMIO PATRON Organization address address: UNIVERSITY CAMPUS RIO PATRAS city: RIO PATRAS postcode: 265 04 website: www.upatras.gr contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.
Coordinator Country	Greece [EL]
Total cost	6˙379˙337 €
EC max contribution	6˙379˙337 € (100%)
Programme	1. H2020-EU.3.1.3. (Treating and managing disease)
Code Call	H2020-SC1-2019-Single-Stage-RTD
Funding Scheme	RIA
Starting year	2020
Duration (year-month-day)	from 2020-01-01 to 2023-12-31

Partnership

Take a look of project's partnership.

#	participants	country	role	EC contrib. [€]
1	PANEPISTIMIO PATRON PANEPISTIMIO PATRON Organization address address: UNIVERSITY CAMPUS RIO PATRAS city: RIO PATRAS postcode: 265 04 website: www.upatras.gr contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	EL (RIO PATRAS)	coordinator	779˙318.00
2	CSEM CENTRE SUISSE D'ELECTRONIQUE ET DE MICROTECHNIQUE SA - RECHERCHE ET DEVELOPPEMENT CSEM CENTRE SUISSE D'ELECTRONIQUE ET DE MICROTECHNIQUE SA - RECHERCHE ET DEVELOPPEMENT Organization address address: RUE JAQUET DROZ 1 city: NEUCHATEL postcode: 2000 website: www.csem.ch contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	CH (NEUCHATEL)	participant	989˙945.00
3	ACONDICIONAMIENTO TARRASENSE ASSOCIACION ACONDICIONAMIENTO TARRASENSE ASSOCIACION Organization address address: CARRER DE LA INNOVACIO 2 city: TERRASSA postcode: 8225 website: www.leitat.org contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	ES (TERRASSA)	participant	854˙335.00
4	GENES'INK GENES'INK Organization address address: 39 AVENUE GASTON IMBERT ZI DE ROUSSET city: ROUSSET postcode: 13790 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	FR (ROUSSET)	participant	740˙062.00
5	KLINIKUM RECHTS DER ISAR DER TECHNISCHEN UNIVERSITAT MUNCHEN KLINIKUM RECHTS DER ISAR DER TECHNISCHEN UNIVERSITAT MUNCHEN Organization address address: ISMANINGER STRASSE 22 city: MUENCHEN postcode: 81675 website: http://www.med.tu.muenchen.de contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	DE (MUENCHEN)	participant	643˙125.00
6	RESCOLL RESCOLL Organization address address: ALLEE GEOFFROY SAINT HILAIRE 8 city: PESSAC postcode: 33600 website: www.rescoll.fr contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	FR (PESSAC)	participant	581˙193.00
7	EURICE EUROPEAN RESEARCH AND PROJECT OFFICE GMBH EURICE EUROPEAN RESEARCH AND PROJECT OFFICE GMBH Organization address address: HEINRICH-HERTZ-ALLEE 1 city: ST INGBERT postcode: 66386 website: www.eurice.eu contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	DE (ST INGBERT)	participant	502˙500.00
8	UNIVERSITY OF LEEDS UNIVERSITY OF LEEDS Organization address address: WOODHOUSE LANE city: LEEDS postcode: LS2 9JT website: www.leeds.ac.uk contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	UK (LEEDS)	participant	490˙232.00
9	OZ BIOSCIENCES SAS OZ BIOSCIENCES SAS Organization address address: PARC SCIENTIFIQUE ET TECHNOLOGIQUE DE LUMINY CASE 922 BAT CCIMP city: MARSEILLE postcode: 13288 website: www.ozbiosciences.com contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	FR (MARSEILLE)	participant	480˙500.00
10	ASPHALION SL ASPHALION SL Organization address address: CALLE TARRAGONA, NUMEROS 151-157, PLANTA 10, BLOQU city: BARCELONA postcode: 8014 website: www.asphalion.com contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	ES (BARCELONA)	participant	318˙125.00

Map

Project objective

The management and reconstruction of bone defects is a significant global healthcare challenge. While autografts offer ideal compatibility, they are often not suitable for large bone defects, and allografts suffer from potential immunorejection.The limited efficacy of conventional treatment strategies for large bone defects and the increasing aged population, has inspired the consortium to propose a SMART RESORBABLE BONE (SRB) IMPLANT embedding stem cells and bioactive agents with the aim of a controllable and fast restoration. The proposed solution includes 3D printed medical grade polymers enriched with electrospun fibers (for increased mechanical properties) that can be customized for patient physiology, pathology, and gender. The scaffold design will ensure easy and minimal Injury placement, and will embed different sensors for monitoring e.g. pressure, pH value and temperature based on biocompatible conductive inks. The smart implant will thus be able to provide vital information of implant performance in terms of bone growth and infection/inflammation. The proposed method is unique because it includes a customized smart implant (3D printed parts with adjustable sensors and communication electronic system), together with tissue engineering methods i.e. in-vitro programming of stem cells for embedding into the smart implant. The proposed solution introduces an innovative regenerative chain, from early testing and characterization (identification/adjustement of the proper specifications) and embedding regenerative stem cells and particulate bioactive agents into the smart implant in preclinical research (in-vitro). The in vivo proof of concept of SBR solution will be tested in (large animal model) preclinical studies within the scope of the project. Finally the regulatory and commercialization strategy on how to further explore the proposed concept and deliver it for clinical testing will be elaborated.

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The information about "SBR" are provided by the European Opendata Portal: CORDIS opendata.

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